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dc.contributor.authorSiafaka, Panoraia
dc.contributor.authorOkur, Mehmet Evren
dc.contributor.authorAyla, Şule
dc.contributor.authorEr, Sevda
dc.contributor.authorÇağlar, Emre Şefik
dc.contributor.authorOkur, Neslihan Üstündağ
dc.date.accessioned2019-12-26T11:04:17Z
dc.date.available2019-12-26T11:04:17Z
dc.date.issued2019en_US
dc.identifier.citationSiafaka, P., Okur, M. E., Ayla, Ş., Er, S., Çağlar, E. Ş ve Okur, N. Ü. (2019). Design and characterization of nanocarriers loaded with Levofloxacin for enhanced antimicrobial activity; physicochemical properties, in vitro release and oral acute toxicity. Brazilian Journal of Pharmaceutical Sciences, 55. http://dx.doi.org/10.1590/s2175-97902019000118295en_US
dc.identifier.issn1984-8250
dc.identifier.issn2175-9790
dc.identifier.urihttp://doi.org/10.1590/s2175-97902019000118295
dc.identifier.urihttps://hdl.handle.net/20.500.12511/4730
dc.description.abstractInorganic and carbon based nanomaterials are widely used against several diseases, such as cancer, autoimmune diseases as well as fungi and bacteria colonization. In this work, Santa Barbara Amorphous mesoporous silica (SBA), Halloysite Nanotubes (HNTs) and Multiwalled Carbon Nanotubes (CNTs) were loaded with fluoroquinolone Levofloxacin (LVF) to be applied as antimicrobial agents. The prepared via adsorption nanocarriers were characterized by Fourier-Transformed Spectroscopy, Scanning Electron Microscopy as well as High Pressure liquid Chromatography. In vitro release studies were carried out using Simulated Body Fluid at 37°C and data analyzed by various kinetic models showing slow dissolution over 12-24 hours. Antimicrobial studies showed improved antibacterial activity against Escherichia coli, Enterococcus faecalis, Listeria monocytogenes, Staphylococcus aureus, and Staphylococcus epidermidis compared to neat nanomaterials. CNTs were found to be the most promising candidates for LVF delivery and they were chosen to be further studied for their acute oral toxicity and histopathological examination using C57/Black mice. Histological examination depicted that drug loading did not affect mice organs morphology as well as hepatocyte degeneration, central vein degeneration and parenchymal necrosis scores. To conclude, the prepared nanomaterials present significant characteristics and can act as antimicrobial drug carriers; CNTs found to be safe candidates when orally fed to mice.en_US
dc.language.isoengen_US
dc.publisherFaculdade de Ciencias Farmaceuticas (Biblioteca)en_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.rightsAttribution 4.0 International*
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/*
dc.subjectCarbon Nanotubesen_US
dc.subjectSanta Barbara Amorphousen_US
dc.subjectHalloysite Nanotubesen_US
dc.subjectLevofloxacinen_US
dc.subjectToxicityen_US
dc.subjectAntimicrobialen_US
dc.titleDesign and characterization of nanocarriers loaded with Levofloxacin for enhanced antimicrobial activity; Physicochemical properties, in vitro release and oral acute toxicityen_US
dc.typearticleen_US
dc.relation.ispartofBrazilian Journal of Pharmaceutical Sciencesen_US
dc.departmentİstanbul Medipol Üniversitesi, Eczacılık Fakültesi, Eczacılık Teknolojisi Bölümü, Farmasötik Teknoloji Ana Bilim Dalıen_US
dc.authorid0000-0001-7256-3230en_US
dc.authorid0000-0003-2143-5268en_US
dc.identifier.volume55en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.doi10.1590/s2175-97902019000118295en_US
dc.identifier.wosqualityQ4en_US
dc.identifier.scopusqualityQ2en_US


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