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dc.contributor.authorAkgün, Feride Sinem
dc.contributor.authorŞirin, Duygu Yaşar
dc.contributor.authorYılmaz, İbrahim
dc.contributor.authorKaraarslan, Numan
dc.contributor.authorÖzbek, Hanefi
dc.contributor.authorŞimşek, Abdullah Talha
dc.contributor.authorKaya, Yasin Emre
dc.contributor.authorKaplan, Necati
dc.contributor.authorAkyuva, Yener
dc.contributor.authorÇalışkan, Tezcan
dc.contributor.authorAteş, Özkan
dc.date.accessioned2019-12-23T08:23:28Z
dc.date.available2019-12-23T08:23:28Z
dc.date.issued2019en_US
dc.identifier.citationAkgün, F. S., Şirin, D. Y., Yılmaz, İ., Karaarslan, N., Özbek, H., Şimşek, A. T. ... Ateş, Ö. (2019). Investigation of the effect of dipyrone on cells isolated from intervertebral disc tissue. Experimental and Therapeutic Medicine, 18(1), 216-224. http://doi.org/ 10.3892/etm.2019.7576en_US
dc.identifier.issn1792-0981
dc.identifier.issn1792-1015
dc.identifier.urihttp://doi.org/ 10.3892/etm.2019.7576
dc.identifier.urihttps://hdl.handle.net/20.500.12511/4597
dc.description.abstractThe present study aimed to evaluate the effects of dipyrone, an indispensable analgesic, anti-pyretic and anti-spasmodic used in emergency departments, on nucleus pulposus and annulus fibrosus cells in vitro. After surgical biopsy, primary cell cultures were prepared from intact intervertebral disc tissues. Dipyrone was administered to the cultures in the experimental groups except for the control group. The data obtained were statistically evaluated. The proliferation was identified to be suppressed via MTT analysis. The gene expression profile of the intervertebral disc cells in the dipyrone-treated groups was significantly changed. The expression of chondroadherin, cartilage oligo matrix protein, interleukin-1 beta and metalloproteinase (MMP)-19 genes were decreased, but MMP-13 and MMP-7 genes expressions were increased, as determined via reverse transcription-quantitative PCR. AO/PI staining revealed that no apoptotic or other type of cell death was detectable after administration of dipyrone does not mean that the drug is innocuous. The occurrence of cellular senescence and/or the halt of cell proliferation may also be important mechanisms underlying the adverse inhibitory effects of dipyrone. Therefore, prior to administering dipyrone in clinical practice, all possible adverse effects of this drug should be considered.en_US
dc.language.isoengen_US
dc.publisherSpandidos Publicationsen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International*
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectAnnulus Fibrosusen_US
dc.subjectDipyroneen_US
dc.subjectIntervertebral Disc Tissueen_US
dc.subjectMetamizoleen_US
dc.subjectNucleus Pulposusen_US
dc.subjectPrimary Cell Cultureen_US
dc.titleInvestigation of the effect of dipyrone on cells isolated from intervertebral disc tissueen_US
dc.typearticleen_US
dc.relation.ispartofExperimental and Therapeutic Medicineen_US
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Tıbbi Farmakoloji Ana Bilim Dalıen_US
dc.authorid0000-0003-2003-6337en_US
dc.authorid0000-0002-8084-7855en_US
dc.identifier.volume18en_US
dc.identifier.issue1en_US
dc.identifier.startpage216en_US
dc.identifier.endpage224en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.doi10.3892/etm.2019.7576en_US
dc.identifier.wosqualityQ3en_US


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