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dc.contributor.authorÜstündağ, Ünsal Veli
dc.contributor.authorÜnal, İsmail
dc.contributor.authorAteş, Perihan Seda
dc.contributor.authorTırpanç, Aybüke
dc.contributor.authorEğilmezer, Gizem
dc.contributor.authorAlturfan, Ahmet Ata
dc.contributor.authorYiğitbaşı, Türkan
dc.contributor.authorEmekli-Alturfan, Ebru
dc.date.accessioned2019-12-19T06:53:22Z
dc.date.available2019-12-19T06:53:22Z
dc.date.issued2019en_US
dc.identifier.citationÜstündağ, Ü. V., Ünal, İ., Ateş, P. S., Tırpanç, A., Eğilmezer, G., Alturfan, A. A. ... Emekli-Alturfan, E. (2019). Effects of water samples in polyethylene terephthalate bottles stored at different conditions on zebrafish embryos with relevance to endocrine disrupting chemical migration and adenomatous polyposis coli tumor suppressor gene. Clinical and Experimental Health Sciences, 9(2), 171-177. https://doi.org/10.33808/clinexphealthsci564016en_US
dc.identifier.issn2459-1459
dc.identifier.urihttps://doi.org/10.33808/clinexphealthsci564016
dc.identifier.urihttps://hdl.handle.net/20.500.12511/4531
dc.description.abstractObjective: Polyethylene terephthalate (PET) is a material that is most commonly used for production of clear plastic bottles. Adenomatous polyposis coli (APC) and beta-catenin have been related with cancer. Aim was to investigate the effects of PET bottled water samples that were exposed to sunlight and hot water on zebrafish embryos. Moreover the effects of these water samples on APC knockdown zebrafish embryos were also evaluated. Methods: Phthalate concentrations in water samples were determined using ELISA. Immunohistochemical method and RT-PCR were used to analyse the expressions of proliferative cell nuclear antigen (PCNA), beta catenin, Wnt 3a and Gsk3 beta. Biochemical parameters were measured using spectrophotometric methods. Vitellogenin concentrations were measured using ELISA and apoptotic cells were evaluated by Acridine Orange staining. Results: Increased PCNA, beta-catenin, Wnt 3a, Gsk3 beta expressions, vitellogenin, nitric oxide, apoptosis and impaired oxidant-antioxidant balance were observed in the exposure groups with these increases being more profound in APC knockdown groups.en_US
dc.description.sponsorshipTurkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK)en_US
dc.description.sponsorshipMarmara Universityen_US
dc.language.isoengen_US
dc.publisherMarmara Universityen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectPolyethylene Terephthalateen_US
dc.subjectPhthalatesen_US
dc.subjectWnt/beta-Catenin Signalingen_US
dc.subjectAdenomatous Polyposis Colien_US
dc.titleEffects of water samples in polyethylene terephthalate bottles stored at different conditions on zebrafish embryos with relevance to endocrine disrupting chemical migration and adenomatous polyposis coli tumor suppressor geneen_US
dc.typearticleen_US
dc.relation.ispartofClinical and Experimental Health Sciencesen_US
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Biyokimya Ana Bilim Dalıen_US
dc.authorid0000-0003-0804-1475en_US
dc.authorid0000-0002-0675-1839en_US
dc.identifier.volume9en_US
dc.identifier.issue2en_US
dc.identifier.startpage171en_US
dc.identifier.endpage177en_US
dc.relation.tubitakinfo:eu-repo/grantAgreement/TUBITAK/SOBAG/114S537en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.doi10.33808/clinexphealthsci564016en_US


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