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The effect of hysteroscopic polypectomy on the gene expression of endometrial receptivity markers: HOXA10, HOXA11 and LIF
(Gene Therapy and Molecular Biology, 2014)The aim of this study is to determine the effect of hysteroscopic polypectomy on the mRNA expression levels of the endometrial receptivity markers, namely, homeobox A10 (HOXA10), homeobox A11 (HOXA11) and leukemia inhibitory ... -
Genetic polymorphisms of Cyp19 and myostatin genes in Turkish indigenous sheep breeds
(Hellenic Veterinary Medical Society, 2017)Growth and meat production traits are very important in sheep breeding. Cyp19 gene has a major role in reproductive activity and growth due to its function in estrogen synthesis. Another gene affecting growth traits is ... -
Detection of allele and genotype frequencies of bovine leukocyte adhesion deficiency, factor XI deficiency and complex vertebral malformation disease genes in holstein cattle
(Ankara University Press, 2019)Hereditary diseases cause yield and economic loses. It is important to examine hereditary diseases at the molecular level and to remove diseases from the herd. In our study, it was aimed to determine allele frequencies of ... -
Evaluation of the antidiabetic activity of Alchemilla persica Rothm. In mice with diabetes induced by alloxan
(Turkish Pharmacists Association, 2019)Objectives: Alchemilla species are used in Turkish folk medicine for the treatment of many diseases together with diabetes. Alchemilla persica, belonging to this genus, is widely distributed in Eastern Anatolia as well as ... -
Optimization of lyophilized LAMP and RT-PCR reaction mixes for detection of tuberculosis
(Sciendo, 2020)Undoubtedly, one of the most infectious diseases in the world is tuberculosis. Key factor for tuberculosis control is to prevent possible contagion with rapid diagnosis and effective treatment. The culture method, which ... -
Neurons from human mesenchymal stem cells display both spontaneous and stimuli responsive activity
(Public Library of Science, 2020)Mesenchymal stem cells have the ability to transdifferentiate into neurons and therefore one of the potential adult stem cell source for neuronal tissue regeneration applications and understanding neurodevelopmental ... -
Optimization of isothermal amplification method for Mycobacterium tuberculosis detection and visualization method for fieldwork
(Türkiye Klinikleri, 2020)Background/aim: Tuberculosis is still one of the most contagious diseases around the world. Key factors of tuberculosis control are rapid diagnostic, efficient treatment, and prevention of contamination by surveillance and ... -
A single center cohort of 40 severe COVID-19 patients who were treated with convalescent plasma
(Tübitak Scientific & Technical Research Council Turkey, 2020)Background/aim: A SARS-Cov2 infection which was first arised from Wuhan in December 2019 and named as COVID-19. Still there lacks either a specific treatment or a vaccine to treat COVID-19. Convalescent plasma (CP) was ... -
Antiproliferative properties and structural analysis of newly synthesized Schiff bases bearing pyrazole derivatives and molecular docking studies
(Elsevier, 2021)New pyrazole Schiffbases containing azo groups were synthesized using the condensation reaction between p-nitrobenzaldehyde and (E)-4-(phenyl)-1-H-pyrazole-3,5-diamine in the molar ratio of 1:2. Characterization of the ... -
Evaluation of antidiabetic activities of scorzonera species on alloxan-induced diabetic mice
(Marmara University Faculty of Health Sciences, 2021)Objective: In Turkish folk medicine, different species of Scorzonera (Asteraceae) have been used in the treatment of various disorders. The study aimed to investigate antidiabetic activity of Scorzonera species and if rutin ... -
Rapid molecular diagnosis of group a streptococcus with a novel loop mediated isothermal amplification method
(Verlag Klinisches Labor GmbH, 2022)Background: Group A Streptococcus (GAS) is the most common bacterial cause of acute tonsillopharyngitis. In this study, it was aimed to evaluate the performance of a novel Loop Mediated Isothermal Amplification (LAMP) ... -
Potential of novel methyl jasmonate analogs as anticancer agents to metabolically target HK-2 activity in glioblastoma cells
(Frontiers Media S.A., 2022)Change in the energy metabolism of cancer cells, which display significant differences compared to normal cells, is a rising phenomenon in developing new therapeutic approaches against cancers. One of the metabolic enzymes, ... -
Biological evaluation of imidazopyridine derivatives as potential anticancer agents against breast cancer cells
(Springer, 2022)Imidazo[1,2-a]pyridine cores have increasing importance in the pharmaceutical industry with their wide range pharmacological activities. In this study, two series of imidazopyridine derivatives were synthesized. It was ... -
Novel β‑hydroxy ketones: Synthesis, spectroscopic characterization, molecular docking, and anticancer activity studies
(Elsevier B. V., 2022)In this study, a series of novel β‑hydroxy ketone derivatives 3a-o were designed, synthesized, and evaluated for their anticancer activity. The structure of these compounds were characterized by IR, 1H and 13C NMR, mass ... -
Characterization and investigation of properties of copper nanoparticle coated TiO2 nanotube surfaces on Ti6Al4V alloy
(Elsevier Ltd, 2022)In this work, to investigate surface, corrosion and in vitro biological properties of the CuNPs-coated nanotube surfaces, antibacterial, bioactive and biocompatible nanoparticle-coated nanotube surfaces were produced on ... -
Design and synthesis of novel caffeic acid phenethyl ester (CAPE) derivatives and their biological activity studies in glioblastoma multiforme (GBM) cancer cell lines
(Elsevier Inc., 2022)Glioblastoma Multiforme (GBM) is the most aggressive brain tumor and classified as one of the deadliest cancers. The current treatment plans for GBM remains to be ineffective because of its rapid progress and inability of ... -
Antileishmanial activity of BNIPdaoct- and BNIPdanon-loaded emulsomes on leishmania infantum parasites
(Frontiers Media S.A., 2022)Among bisnaphthalimidopropyl (BNIP) derivatives, BNIPDaoct and BNIPDanon recently came forward with antileishmanial activities beyond the standard, commercialized antileishmanial therapies. However, high-level toxicity on ... -
Synthesis of novel oxadiazole derivatives and their cytotoxic activity against various cancer cell lines
(TUBITAK, 2022)Caffeic acid (CA), ferulic acid (FA) and caffeic acid phenethyl ester (CAPE) have a broad anticancer effect on various cell lines. In this study, nine ferulic and caffeic acid-based 1,2,4 and 1,3,4 oxadiazole molecular ... -
The optimal method to measure polyamines in serum by using HPLC fluorescence detector
(Istanbul Medipol University, 2023)Measurement of polyamines (putrescine, spermidine and spermine) is important in the monitoring of many metabolic events, as well as in cancer prognosis. However, the lack of method standardization and validation for the ... -
Synthesis of novel hybrid lonidamine-coumarin derivatives and their anticancer activities
(Elsevier B.V., 2023)In order to develop drugs against cancer, which is one of the deadliest diseases in the world, hybridizing structures with known anticancer activity can provide a dual activity for the treatment of cancer cases. For this ...