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Toplam kayıt 6, listelenen: 1-6
The effect of rifampicin on the neuronal cell survival in primary cortical neuron culture after laser axotomy
(2019)
Aim: Neurodegeneration caused by the axonal injury is a widely seen phenomenon
in spinal cord and traumatic brain injuries. Due to the disintegration of the synaptic
connection neurotrophic factors could not be transported ...
A different view on the platelet aggregation inhibitor clopidogrel - a well-suitable anti-oedema agent in a preclinical model of brain injury?
(Czech Medical Soc, 2019)
Aim: The neuroprotective effects of clopidogrel have already been shown in various experimental models. Taking into account the fact that clopidogrel is well tolerated and approved for use in various clinical settings, it ...
Melatonin affects the release of exosomes and tau-content in in vitro amyloid-beta toxicity model
(Elsevier Science Ltd., 2020)
Background: Recent studies have been revealed that oxidative damage is the main cause of aging and age-related neurodegenerative diseases like Alzheimer's disease (AD). Melatonin is secreted from the pineal gland and its ...
Minocycline increases in-vitro cortical neuronal cell survival after laser induced axotomy
(2020)
Antibiotic therapies targeting multiple regenerative mechanisms have the potential for neuroprotective effects, but the diversity of experimental strategies and analyses of non-standardised therapeutic trials are challenging. ...
A different view on the pathophysiology of Parkinson’s disease: A descendent neurochemical hypothesis?
(Wolters Kluwer, 2019)
It has been already shown that Parkinson’s disease (PD) is characterized by a prominent degeneration in substantia nigra (SN)neurons. Growing evidence suggests that there is a latent period of PD associated with slight ...
Therapeutic role of rifampicin in Alzheimer's disease
(Wiley, 2018)
Rifampicin exerts significant brain protective functions in multiple experimental models. Here we summarize the underlying mechanisms of the neuroprotective and pro-cognitive effects of rifampicin that are mediated by its ...