ORCID "0000-0003-1106-3288" Rektörlüğe Bağlı Birimler için listeleme
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Combined segmentation and classificationbased approach to automated analysis of biomedical signals obtained from calcium imaging
Dursun, Gizem; Bijelić, Dunja; Ayşit, Neşe; Kurt Vatandaşlar, Burcu; Radenović, Lidija; Çapar, Abdulkerim; Kerman, Bilal Ersen; Andjus, Pavle R.; Korenić, Andrej; Özkaya, Ufuk (Public Library of Science, 2023)Automated screening systems in conjunction with machine learning-based methods are becoming an essential part of the healthcare systems for assisting in disease diagnosis. Moreover, manually annotating data and hand-crafting ... -
Comparison of central and peripheral myelination dynamics
Kerman Ersen, Bilal (Wiley-Blackwell, 2016)... -
Differentiation of inflammation-responsive astrocytes from glial progenitors generated from human induced pluripotent stem cells
Santos, Renata; Vadodaria, Krishna C.; Jaeger, Baptiste N.; Mei, Arianna; Lefcochilos-Fogelquist, Sabrina; Mendes, Ana P. D.; Erikson, Galina; Shokhirev, Maxim; Randolph-Moore, Lynne; Fredlender, Callie; Dave, Sonia; Oefner, Ruth; Fitzpatrick, Conor; Pena, Monique; Barron, Jerika J.; Ku, Manching; Denli, Ahmet M.; Kerman, Bilal Ersen; Charnay, Patrick; Kelsoe, John R.; Marchetto, Maria C.; Gage, Fred H. (Cell Press, 2017)Astrocyte dysfunction and neuroinflammation are detrimental features in multiple pathologies of the CNS. Therefore, the development of methods that produce functional human astrocytes represents an advance in the study of ... -
Identification of protein-protein interaction bridges for multiple sclerosis
Yazıcı, Gözde; Kurt Vatandaşlar, Burcu; Aydın Cantürk, İlknur; Aydınlı, Fatmagül İlayda; Arıcı Düz, Özge; Karakoç, Emre; Kerman, Bilal Ersen; Alkan, Can (Oxford University Press, 2023)Motivation: Identifying and prioritizing disease-related proteins is an important scientific problem to develop proper treatments. Network science has become an important discipline to prioritize such proteins. Multiple ... -
In vitro myelin formation using embryonic stem cells
Kerman, Bilal Ersen; Kim, Hyung-joon; Padmanabhan, Krishnan; Mei, Arianna; Georges, Shereen; Joens, Matthew; Fitzpatrick, James; Jappelli, Roberto; Chandross, Karen; August, Paul; Gage, Fred (Company of Biologists, 2015)Myelination in the central nervous system is the process by which oligodendrocytes form myelin sheaths around the axons of neurons. Myelination enables neurons to transmit information more quickly and more efficiently and ... -
Motoneuron expression profiling identifies an association between an axonal splice variant of HDGF-related protein 3 and peripheral myelination
Kerman, Bilal Ersen; Genoud, Stephane; Kurt Vatandaşlar, Burcu; Denli, Ahmet Murat; Ghosh, Shereen Georges; Xu, Xiangdong; Yeo, Gene W.; Aimone, James Bradley; Gage, Fred H. (American Society for Biochemistry and Molecular Biology Inc, 2020)Disorders that disrupt myelin formation during development or in adulthood, such as multiple sclerosis and peripheral neuropathies, lead to severe pathologies, illustrating myelin's crucial role in normal neural functioning. ... -
A multi-spectral myelin annotation tool for machine learning based myelin quantification [version 1; peer review: 1 not approved]
Çapar, Abdulkerim; Çimen Yetiş, Sibel; Aladağ, Zeynep; Ekinci, Dursun Ali; Ayten, Umut Engin; Kerman, Bilal Ersen; Töreyin, Behçet Uğur (F1000 Research Ltd, 2021)Myelin is an essential component of the nervous system and myelin damage causes demyelination diseases. Myelin is a sheet of oligodendrocyte membrane wrapped around the neuronal axon. In the fluorescent images, experts ... -
Multiple sclerosis biomarker candidates revealed by cell-type-specific interactome analysis
Yurduseven, Kübra; Babal, Yigit Koray; Çelik, Eşref; Kerman, Bilal Ersen; Aksan Kurnaz, Işıl (Mary Ann Liebert, 2022)Multiple sclerosis (MS) is a demyelinating disorder that affects multiple regions of the central nervous system such as the brain, spinal cord, and optic nerves. Susceptibility to MS, as well as disease progression rates, ... -
Myelin disorders and stem cells: As therapies and models
Aydınlı, Fatmagül İlayda; Çelik, Eşref; Kurt Vatandaşlar, Burcu; Kerman, Bilal Ersen (Tubitak Scientific & Technical Research Council, 2016)Myelin disorders burden millions of people around the world, yet existing therapies are inadequate to cure them. Current remedies commonly treat the symptoms with minimal to no effect on the actual cause of the disorder. ... -
NextGen Voices: Quality mentoring
Segal, Lauren; Agarwal, Divyansh; Isaacson, Kyle J; Oehmke, Theresa B; Kumar, Brijesh; Chen, Jennifer Shuen; Cusimano, Joseph Michael; Negi, Swati; Tiper, Irina; Bakermans, Adrianus J; Jensen, Mark Martin; Sanganyado, Edmond; Zaidi, Syed Shan-E-Ali; Romero-Molina, Carmen; Martinez, Santiago Esteban; Anderson, Sarah Marie; Santos, Guilherme Martins; de Lella Ezcurra, Ana Laura; Farragher, Janine; Sharma, Vandana; Duncan, Gregg; Dutton-Regester, Ken; Kim, Sun Ae; Yu, Sha; Schwendimann, Beat a; K V Reichardt, Juergen; Halder, Antarip; Dennis, Allison F; Ellwanger, Joel Henrique; Chiu, Yu-Han; Kerman, Bilal Ersen (New York, N.Y., 2018)In her Working Life, “Paying it forward as a mentor” (3 August, p. 522),B. Abderrahman describes how a mentor’s encouragement can help shapea career. She then explains how her positive mentorship experienceinspired her to ... -
Particular phosphorylation of PI3K/Akt on Thr308 via PDK-1 and PTEN mediates melatonin's neuroprotective activity after focal cerebral ischemia in mice
Kılıç, Ülkan; Çağlayan, Ahmet Burak; Beker, Mustafa Çağlar; Günal, Mehmet Yalçın; Çağlayan, Berrak; Yalçın, Esra; Keleştemur, Taha; Gündoğdu, Reyhan Zeynep; Yuluğ, Burak; Yılmaz, Bayram; Kerman, Bilal Ersen; Kılıç, Ertuğrul (Elsevier Sciences Bv, 2017)Apart from its potent antioxidant property, recent studies have revealed that melatonin promotes PI3K/Akt phosphorylation following focal cerebral ischemia (FCI) in mice. However, it is not clear (i) whether increased ... -
Refractive index tomography of myelinating glial cells
Toy, Muhammed Fatih; Kurt Vatandaşlar, Burcu; Kerman, Bilal Ersen (SPIE-Int Soc Optical Engineering, 2019)Refractive index tomography as an emerging technique enables the 3D morphological investigation of cells with no marker. Here, refractive index tomographic imaging of myelinating glial cells is presented. Myelin as a signal ... -
Science-inspired sustainable behavior
Kumar, Brijesh; Jensen, Mark Martin; Strielkowski, Wadim; Johnston, Juliet Tegan; Sharma, Vandana; Dandara, Collet; Shehata, Mahmoud M.; Struett. Michelle Micarelli; Nikolaou, Athanasia; Szymanski, David W.; Abdul-Ghani, Rashad; Cao, Bo; Varzinczak, Luiz H.; Kerman, Bilal Ersen; Arthur, Patrick Kobina; Oda, Fernanda Suemi; Bohon, Wendy; Ellwanger, Joel Henrique; Tyner, Sam; Joseph Jordan, E.; Murphy, Colin (American Association for the Advancement of Science, 2019)We asked young scientists this question: How has your awareness of science inspired you to adopt more sustainable and environmentally friendly behavior? Respondents from around the world described scientifi c concepts, ... -
Species-specific maturation profiles of human, chimpanzee and bonobo neural cells
Marchetto, Maria Carolina; Hrvoj-Mihic, Branka; Kerman, Bilal Ersen; Yu, Diana X.; Vadodaria, Krishna C.; Linker, Sara B.; Narvaiza, Inigo; Santos, Renata; Denli, Ahmet M.; Mendes, Ana P. D.; Oefner, Ruth; Cook, Jonathan; McHenry, Lauren; Grasmick, Jaeson M.; Heard, Kelly; Fredlender, Callie; Randolph-Moore, Lynne; Kshirsagar, Rijul; Xenitopoulos, Rea; Chou, Grace; Hah, Nasun; Muotri, Alysson R.; Padmanabhan, Krishnan; Semendeferi, Katerina; Gage, Fred H. (Elife Sciences Publications Ltd, 2019)Comparative analyses of neuronal phenotypes in closely related species can shed light on neuronal changes occurring during evolution. The study of post-mortem brains of nonhuman primates (NHPs) has been limited and often ... -
Two phases of macrophages: Inducing maturation and death of oligodendrocytes in vitro co-culture
Aydınlı, Fatmagül İlayda; Er, Sezgin; Kerman, Bilal Ersen (Elsevier B.V., 2022)Background: The plasticity of macrophages in the immune response is a dynamic situation dependent on external stimuli. The activation of macrophages both has beneficial and detrimental effects on mature oligodendrocytes ... -
α-Synuclein-induced myelination deficit defines a novel interventional target for multiple system atrophy
Ettle, Benjamin; Kerman, Bilal Ersen; Valera-Martin, Elvira; Gillmann, Clarissa; Schlachetzki, Johannes Carolus Magnus; Reiprich, Simone; Büttner, Christian; Ekici, Arif Bülent; Reis, André; Wegner, Michael M.; Baüerle, Tobias J.; Riemenschneider, Markus Johannes; Masliah, Eliezer; Gage, Fred H.; Winkler, Jürgen (Springer, 2016)Multiple system atrophy (MSA) is a rare atypical parkinsonian disorder characterized by a rapidly progressing clinical course and at present without any efficient therapy. Neuropathologically, myelin loss and neurodegeneration ...