ORCID "0000-0003-0957-6965" Rektörlüğe Bağlı Birimler için listeleme
-
Biological evaluation of imidazopyridine derivatives as potential anticancer agents against breast cancer cells
Sucu, Bilgesu Onur (Springer, 2022)Imidazo[1,2-a]pyridine cores have increasing importance in the pharmaceutical industry with their wide range pharmacological activities. In this study, two series of imidazopyridine derivatives were synthesized. It was ... -
Design and synthesis of novel caffeic acid phenethyl ester (CAPE) derivatives and their biological activity studies in glioblastoma multiforme (GBM) cancer cell lines
Onur Sucu, Bilgesu; Koç, Elif Beyza; Şavluğ İpek, Özgecan; Mirat, Afranur; Almas, Furkan; Güzel, Melike Aybala; Doğan, Berna; Uludağ, Damla; Karakaş, Nihal; Durdağı, Serdar; Güzel, Mustafa (Elsevier Inc., 2022)Glioblastoma Multiforme (GBM) is the most aggressive brain tumor and classified as one of the deadliest cancers. The current treatment plans for GBM remains to be ineffective because of its rapid progress and inability of ... -
Development of light and pH-dual responsive self-quenching theranostic SPION to make EGFR overexpressing micro tumors glow and destroy
Verimli, Nihan; Goralı, Selen İrem; Abişoğlu, Beyza; Altan, Cem Levent; Sucu, Bilgesu Onur; Karataş, Ersin; Tülek, Ahmet; Bayraktaroğlu, Çiğdem; Beker, Mustafa Çağlar; Erdem, Sultan Sibel (Elsevier B.V., 2023)Drug resistant and undetectable tumors easily escape treatment leading metastases and/or recurrence of the lethal disease. Therefore, it is vital to diagnose and destroy micro tumors using simple yet novel approaches. Here, ... -
Potential of novel methyl jasmonate analogs as anticancer agents to metabolically target HK-2 activity in glioblastoma cells
Uludağ, Damla; Bay, Sadık; Onur Sucu, Bilgesu; Şavluğ İpek, Özgecan; Mohr, Thomas; Güzel, Mustafa; Karakaş, Nihal (Frontiers Media S.A., 2022)Change in the energy metabolism of cancer cells, which display significant differences compared to normal cells, is a rising phenomenon in developing new therapeutic approaches against cancers. One of the metabolic enzymes, ... -
Synthesis and antiproliferative evaluation of new 1,3,5-trisubstituted 1,2,4-triazole derivatives against glioblastoma cell lines
Koç, Elif Beyza; Sucu, Bilgesu Onur (Wiley, 2023)A series of novel 1,3,5-trisubstituted-1,2,4-triazole derivatives were successfully synthesized from the starting materials of caffeic acid (CA) and ferulic acid (FA) in moderate to good yields (45-71 %). All novel compounds ... -
Synthesis of new imidazo[1,2-a]pyridine triazole hybrid molecules as potential apoptotic antitumor agents
Albayrak Halaç, Fatma; Eşsiz, Şebnem; Servili, Burak; Altundaş, Ramazan; Onur Sucu, Bilgesu; Kulu, İrem (John Wiley and Sons Inc, 2024)Novel imidazo[1,2-a]pyridines bearing 1,2,3-triazole moieties at the C3 position were synthesized. After the characterization of the synthesized compounds, their in vitro therapeutic activities were evaluated in various ... -
Synthesis of novel oxadiazole derivatives and their cytotoxic activity against various cancer cell lines
Sucu, Bilgesu Onur; Koç, Elif Beyza (TUBITAK, 2022)Caffeic acid (CA), ferulic acid (FA) and caffeic acid phenethyl ester (CAPE) have a broad anticancer effect on various cell lines. In this study, nine ferulic and caffeic acid-based 1,2,4 and 1,3,4 oxadiazole molecular ...