Başlık için Rektörlüğe Bağlı Birimler listeleme
Toplam kayıt 535, listelenen: 307-326
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Lamotrigine derivatives-synthesis, anti-cancer, and anti-MDR-bacterial activities
(Elsevier B.V., 2022)A new series of quaternary ammonium salts 3–21 of lamotrigine (6-(2, 3-dichlorophenyl)-1, 2, 4-triazine-3, 5-diamine) was synthesized via N-alkylation of lamotrigine using different benzyl bromides. The new analogues were ... -
Laurocerasus officinalis Roem. fruit extract induces cell death through caspase mediated apoptosis in gastric cancer cell lines
(Walter de Gruyter GmbH, 2021)Objectives: Laurocerasus officinalis Roem. fruits are traditionally used for several health problems. Although there are some studies about its antiproliferative effects on different cancer cells, no study was reported ... -
Leaching of iron and chromium from an indigenous ferro chromium alloy via a rotary evaporator: Optimum conditions determination and kinetic analysis
(Elsevier, 2020)In the leaching process of chromium-containing precursor hexavalent chromium may form, which provokes damages to environment and human health. As a solution, leaching the chromium containing precursor with sulphuric acid ... -
Left lateral parietal rTMS improves cognition and modulates resting brain connectivity in patients with Alzheimer's disease: Possible role of BDNF and oxidative stress
(Academic Press Inc., 2021)Repetitive Transcranial Magnetic Stimulation (rTMS) is a non-invasive neuromodulation technique which is increasingly used for cognitive impairment in Alzheimer?s Disease (AD). Although rTMS has been shown to modify ... -
Lentivirally administered glial cell line-derived neurotrophic factor promotes post-ischemic neurological recovery, brain remodeling and contralesional pyramidal tract plasticity by regulating axonal growth inhibitors and guidance proteins
(Academic Press Inc Elsevier Science, 2020)Owing to its potent longterm neuroprotective and neurorestorative properties, glial cell line-derived neurotrophic factor (GDNF) is currently studied in neurodegenerative disease clinical trials. However, little is known ... -
Leptin in sperm analysis can be a new indicator
(Elsevier GMBH, 2019)Purpose Radiotherapy, chemotherapy, various tumors and invasive surgery can result in ejaculatory dysfunction and testicular insufficiency. Sperm cryopreservation is the only method which can provide a baby for couples. ... -
Light transmittance and surface roughness of a feldspathic ceramic CAD-CAM material as a function of different surface treatments
(BioMed Central Ltd., 2016)Background: The aim of the present study was to determine the effect of different surface treatments on light transmission of aesthetic feldspathic ceramics used in CAD-CAM chairside restorations. Methods: Forty eight ... -
Linker residues regulate the activity and stability of hexokinase 2, a promising anticancer target
(American Society for Biochemistry and Molecular Biology Inc., 2021)Hexokinase (HK) catalyzes the first step in glucose metabolism, making it an exciting target for the inhibition of tumor initiation and progression due to their elevated glucose metabolism. The upregulation of hexokinase-2 ... -
Lithium modulates miR-1906 levels of mesenchymal stem cell-derived extracellular vesicles contributing to poststroke neuroprotection by toll-like receptor 4 regulation
(Wiley, 2021)Lithium is neuroprotective in preclinical stroke models. In addition to that, poststroke neuroregeneration is stimulated upon transplantation of mesenchymal stem cells (MSCs). Preconditioning of MSCs with lithium further ... -
Lithium promotes long-term neurological recovery after spinal cord injury in mice by enhancing neuronal survival, gray and white matter remodeling, and long-distance axonal regeneration
(Frontiers Media S.A., 2022)Spinal cord injury (SCI) induces neurological deficits associated with long-term functional impairments. Since the current treatments remain ineffective, novel therapeutic options are needed. Besides its effect on bipolar ... -
Lithium-induced neuroprotection in stroke involves increased miR-124 expression, reduced RE1-silencing transcription factor abundance and decreased protein deubiquitination by GSK3 beta inhibition-independent pathways
(Sage Publication Inc., 2017)Lithium promotes acute poststroke neuronal survival, which includes mechanisms that are not limited to GSK3 inhibition. However, whether lithium induces long-term neuroprotection and enhanced brain remodeling is unclear. ... -
Long-term treatment with chloroquine increases lifespan in middle-aged male mice possibly via autophagy modulation, proteasome inhibition and glycogen metabolism
(Impact Journals LLC, 2022)Previous studies have shown that the polyamine spermidine increased the maximum life span in C. elegans and the median life span in mice. Since spermidine increases autophagy, we asked if treatment with chloroquine, an ... -
Longitudinal 16S rRNA data derived from limb regenerative tissue samples of axolotl ambystoma mexicanum
(Nature Publishing Group, 2019)The Mexican axolotl (Ambystoma mexicanum) is a critically endangered species and a fruitful amphibian model for regenerative biology. Despite growing body of research on the cellular and molecular biology of axolotl limb ... -
Longitudinal metabolomics analysis reveals the acute effect of cysteine and NAC included in the combined metabolic activators
(Elsevier Inc., 2023)Growing evidence suggests that the depletion of plasma NAD+ and glutathione (GSH) may play an important role in the development of metabolic disorders. The administration of Combined Metabolic Activators (CMA), consisting ... -
A longitudinal study of the association between depression, anxiety and stress symptoms of university students in Serbia with excessive social media use before and during COVID-19 pandemic
(Frontiers Media SA, 2023)Background: Besides the well known good side of social media, it cannot be denied some of its negative effects. This two-phase study aimed to find out whether the usage of social media during the COVID-19 pandemic showed ... -
Low frequency oscillations during hand laterality judgment task with and without personal perspectives: a preliminary study
(Springer, 2023)Sense of personal perspective is crucial for understanding in attentional mechanisms of the perception in "self" or "other's" body. In a hand laterality judgment (HLJ) task, perception of perspective can be assessed by ... -
Low oxalobacter formigenes colonization is associated with reduced bone mineral density in urinary stone forming patients
(S. Karger AG, 2014)Introduction: Lower bone mineral density (BMD) and reduced Oxalobacter formigenes colonization are common findings in urolithiasis patients. But none of the studies conducted investigated the relationship between decreased ... -
Lower prepulse inhibition in clinical high-risk groups but not in familial risk groups for psychosis compared with healthy controls
(Wiley, 2020)Aim: Although the lower level of prepulse inhibition (PPI) of the startle response is well known in schizophrenia, the onset of this difference is not clear. The aim of the present study was to compare PPI in individuals ... -
Male infertility, azoozpermia and cryptozoospermia incidence among three infertility clinics in Turkey
(AVES İbrahim Kara, 2018)Objective: Semen parameters are directly correlated with the infertility of the male. Incidence rates of male factor infertility, azoospermia and cryptozoospermia differ according to many factors such as geographic region, ... -
Maskless lithography with holographic feedback for the fabrication of optical elements
(SPIE, 2022)Photolithography has become a powerful tool in the fabrication of micro-optical elements following the advancements in grayscale approaches. However, hitting tight design tolerance goals require precise control of all ...
