ORCID "0000-0002-1423-0435" Eczane Hizmetleri için listeleme
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Design and synthesis of novel cylopentapyrazoles bearing 1,2,3-thiadiazole moiety as potent antifungal agents
Giray, Betül; Karadağ, Ayşe Esra; Şavluğ İpek, Özgecan; Pekel, Hanife; Güzel, Mustafa; Başpınar Küçük, Hatice (Elsevier, 2020)In drug-resistant phytopathogenic fungi, there has been extensive research on microbiological and antifungal drug development. In this study, a novel series of cylopentapyrazole bearing a 1,2,3-thiadiazole ring 2a-e were ... -
Mechanistic insight into impact of phosphorylation on the enzymatic steps of farnesyltransferase
Pekel, Hanife; Güzel, Mustafa; Şensoy, Özge (Wiley, 2022)Farnesyltransferase (FTase) is a heterodimeric enzyme, which catalyzes covalent attachment of the farnesyl group to target proteins, thus coordinating their trafficking in the cell. FTase has been demonstrated to be highly ... -
Novel synthetic approaches for bisnaphthalimidopropyl (BNIP) derivatives as potential anti-parasitic agents for the treatment of leishmaniasis
Keskin, Elif; Üçışık, Mehmet Hikmet; Sucu, Bilgesu Onur; Güzel, Mustafa (MDPI, 2019)Leishmaniasis is a neglected parasitic disease that is widely seen in more than 60 countries worldwide, including Turkey and its subcontinental region. There are several chemotherapy agents for the treatment of leishmaniasis, ... -
Synthesis of novel methyl jasmonate derivatives and evaluation of their biological activity in various cancer cell lines
Onur Sucu, Bilgesu; Savluğ İpek, Özgecan; Özdatlı Kurtuluş, Şükran; Yazıcı, Büşra Emine; Karakaş, Nihal; Güzel, Mustafa (Academic Press Inc Elsevier Science, 2019)Warburg hypothesized that the energy consumption of cancer cells is different than the normal cells. When compared to normal conditions, cancer cells do not undergo tricarboxylic acid (TCA) cycle therefore resulting in ...