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Digenic DUOX1 and DUOX2 mutations in cases with congenital hypothyroidism
(Oxford University Press Inc, 2017)
Context: The DUOX2 enzyme generates hydrogen peroxide (H2O2), a crucial electron acceptor for the thyroid peroxidase-catalyzed iodination and coupling reactions mediating thyroid hormone biosynthesis. DUOX2 mutations result ...
Efficient transgenesis and annotated genome sequence of the regenerative flatworm model Macrostomum lignano
(Nature Publishing Group, 2017)
Regeneration-capable flatworms are informative research models to study the mechanisms of stem cell regulation, regeneration, and tissue patterning. However, the lack of transgenesis methods considerably hampers their wider ...