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Phosphodiesterase 10A is a critical target for neuroprotection in a mouse model of ischemic stroke
(Springer, 2022)
Phosphodiesterase 10A (PDE10A) hydrolyzes adenosine 3 ',5 '-cyclic monophosphate (cAMP) and guanosine 3 ',5 '-cyclic monophosphate (cGMP). It is highly expressed in the striatum. Recent evidence implied that PDE10A may be ...
Percutaneous closure of atrial septal defects with the memopart atrial septal occluder: The early-term results of a multicenter study
(Springer, 2022)
Atrial septal defect (ASD) is a common congenital heart disease with left-to-right shunt that may lead to pulmonary hypertension over time. Secundum ASD closure with transcatheter technique is currently the preferred method. ...
Resting state alpha electroencephalographic rhythms are affected by sex in cognitively unimpaired seniors and patients with alzheimer's disease and amnesic mild cognitive impairment: A retrospective and exploratory study
(Oxford University Press Inc, 2022)
In the present retrospective and exploratory study, we tested the hypothesis that sex may affect cortical sources of resting state eyes-closed electroencephalographic (rsEEG) rhythms recorded in normal elderly (Nold) seniors ...
Response to first-line chemotherapy regimen is associated with efficacy of immune checkpoint blockade therapies in patients with metastatic urothelial carcinoma
(Springer, 2022)
Background Atezolizumab (ATZ) has demonstrated antitumor activity in previous studies in patients with metastatic platinum-resistant urothelial carcinoma. However, the response rate of ATZ was modest. Therefore, finding ...
Surgery for secondary hyperparathyroidism. Total or subtotal?
(Springer India, 2022)
Objectives Secondary hyperparathyroidism (sHPT) develops as a result of the chronic parathyroid stimulation associated with hypocalcemia, hyperphosphatemia, or vitamin D deficiency and leads to an increase in parathormone ...
The relationship between hepatic high FIB-4 score and COVID-19 pneumonia
(Clinical Laboratory Publication, 2022)
Background: We aimed to compare the level of hepatic FIB-4 scores between COVID-19 patients who had pneu-monia and COVID-19 patients who had no pneumonia in an attempt to develop a risk assessment after the treat-ment and ...
The role of three dimensional transesophageal echocardiography novel-score in the success of redo percutaneous balloon mitral valvuloplasty
(Springer, 2022)
Mitral valve commissure evaluation is known to be important in the success of percutaneous balloon mitral valvuloplasty (PBMV) and Wilkins score (WS) is used in clinical practice. In our study, we aimed to determine whether ...
The real-life efficacy and safety of osimertinib in pretreated advanced non-small cell lung cancer patients with T790M mutation: A Turkish Oncology Group Study
(Springer, 2022)
Introduction Osimertinib, an irreversible third-generation EGFR-TKI, is the standard of care for second-line treatment of T790M-mutant advanced NSCLC patients whose disease progressed after first-line EGFR-TKI therapy. In ...
COVID-19 reminds us: Community vitamin D deficiency
(Edizioni Luigi Pozzi, 2020)
AIM: The aim of this study was to compare the vitamin D levels between the group of patients diagnosed with COVID-19 and healthy controls, and to investigate the relationship between vitamin D levels and various clinical ...
Analysis of atherosclerosis by inductively coupled plasma optical emission spectroscopy and scanning acoustic microscopy
(Institute of Physics Publishing, 2020)
Calcium deposition within the atherosclerotic plaques is the precursor of cardiovascular complications. Therefore, determination of levels of minerals and trace elements in blood plays an important role in assigning the ...