Kurum Yazarı "Üstündağ, Ünsal Veli" Makale Koleksiyonu İçin Listeleme
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3-Pyridinylboronic acid ameliorates rotenone-induced oxidative stress through Nrf2 target genes in zebrafish embryos
Üstündağ, Fümet Duygu; Ünal, İsmail; Üstündağ, Ünsal Veli; Cansız, Derya; Beler, Merih; Karagöz, Atakan; Kara Subaşat, Hülya; Alturfan, Ahmet Ata; Mega Tiber, Pınar; Emekli Alturfan, Ebru (Springer, 2022)Parkinson's disease (PD) is one of the most common forms of neurodegenerative diseases and research on potential therapeutic agents for PD continues. Rotenone is a neurotoxin that can pass the blood-brain barrier and is ... -
3-Pyridinylboronic acid normalizes the effects of 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine exposure in zebrafish embryos
Üstündağ, Fümet Duygu; Ünal, İsmail; Cansız, Derya; Üstündağ, Ünsal Veli; Kara Subaşat, Hülya; Alturfan, Ahmet Ata; Mega Tiber, Pınar; Emekli Alturfan, Ebru (Taylor & Francis Ltd, 2022)1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) is a neurotoxin that damages dopaminergic neurons. Zebrafish has been shown to be a suitable model organism to investigate the molecular pathways in the pathogenesis of ... -
Amelioration of rotenone-induced alterations in energy/redox system, stress response and cytoskeleton proteins by octanoic acid in zebrafish: A proteomic study
Sürmen, Mustafa Gani; Sürmen, Saime; Cansız, Derya; Ünal, İsmail; Üstündağ, Ünsal Veli; Alturfan, Ahmet Ata; Büyükkayhan, Derya; Emekli Alturfan, Ebru (Wiley, 2022)Rotenone is used to generate Parkinson's disease (PD)-like symptoms in experimental animals. Octanoic acid (C8), is the principal fatty acid of medium-chain triglycerides in ketogenic diets. Beneficial effects of ketogenic ... -
The biocompatibility of a ginger-containing herbal toothpaste on developing zebrafiish embryos
Meşeli, Simge; Üstündağ, Ünsal Veli; Ateş, Perihan Seda; Ünal, İsmail; Işık Alturfan, Ebru (Universitas Indonesia, 2023)The biocompatibility of toothpaste in an oral cavity should be approved by clinical trials. Nowadays, herbal toothpaste is increasing in popularity due to its natural ingredients. Being genetically similar to humans, ... -
Bisphenol a reveals its obesogenic effects through disrupting glucose tolerance, oxidant–antioxidant balance, and modulating inflammatory cytokines and fibroblast growth factor in zebrafish
Beler, Merih; Cansız, Derya; Ünal, İsmail; Üstündağ, Ünsal Veli; Dandin, Esra; Ak, Esin; Alturfan, A. Ata; Emekli Alturfan, Ebru (SAGE Publications Ltd, 2022)Obesogens affect lipid metabolism, and genetic or epigenetic factors may also contribute to the progression of obesity. Endocrine-disrupting chemicals (EDCs) are the most striking among obesogens. Bisphenol A (BPA) is an ... -
Chard extract increased gastric sialic acid and ameliorated oxidative stress in valproic acid-administered rats
Alev Tüzüner, Burçin; Tunalı, Sevim; Üstündağ, Ünsal Veli; İpekçi, Hazal; Emekli Alturfan, Ebru; Tunalı Akbay, Tuğba; Yanardağ, Refiye; Yarat, Ayşen (ScientificWebJournals (SWJ) Özkan Özden, 2023)Valproic acid, one of the most used drugs for epilepsy patients, has some known side effects. Chard extract has many pharmacological activities. The study aims to evaluate whether valproic acid might interfere with oxidative ... -
Determination of bisphenol a and phthalate levels in wastewater samples
Akçay, Mansur; Ateş Kalkan, Perihan Seda; Üstündağ, Ünsal Veli; Ünal, İsmail; Cansız, Derya; Emekli Alturfan, Ebru; Alturfan, Ahmet Ata (Istanbul University, 2022)Objective: The use of endocrine-disrupting chemicals (EDCs) such as bisphenol A (BPA) in plastics manufacturing, agriculture, livestock, and paint manufacturing increas daily. The water treated in wastewater treatment ... -
The effect of acetic acid-induced pain in Parkinson's disease model in zebrafish
Cansız, Derya; Ünal, İsmail; Beler, Merih; Üstündağ, Ünsal Veli; Ak, Esin; Emekli Alturfan, Ebru; Alturfan, Ahmet Ata (Elsevier B.V., 2023)Parkinson's disease (PD) is the second most common neurodegenerative disease caused by the degeneration of dopaminergic neurons and the accumulation of Lewy bodies. Pain is one of the most common non-motor symptoms in PD, ... -
The effect of different storage conditions on the migration of chemicals from polyethylene terephthalate and polycarbonate bottles to water
Seyhan, Gümrah; Üstündağ, Ünsal Veli; Ünal, İsmail; Ateş Kalkan, Perihan Seda; Cansız, Derya; Emekli Alturfan, Ebru; Alturfan, Ahmet Ata (Istanbul University, 2022)Objective: Polyethylene terephthalate (PET) and polycarbonate (PC) bottles have been used widely in the last years for the consumption of water and the increased use of these chemicals has raised many concerns regarding ... -
Identification of molecular network of gut-brain axis associated with neuroprotective effects of PPAR delta-ligand erucic acid in rotenone-induced Parkinson's disease model in zebrafish
Ünal, İsmail; Cansız, Derya; Sürmen, Mustafa Gani; Sürmen, Saime; Sezer, Zehra; Beler, Merih; Üstündağ, Ünsal Veli; Güzel, Elif; Alturfan, Ahmet Ata; Emekli Alturfan, Ebru (Wiley, 2023)Disruption of the gut-brain axis in Parkinson's disease (PD) may lead to motor symptoms and PD pathogenesis. Recently, the neuroprotective potential of different PPAR delta-agonists has been shown. We aimed to reveal the ... -
Morphine ameliorates pentylenetetrazole-induced locomotor pattern in zebrafish embryos; mechanism involving regulation of opioid receptors, suppression of oxidative stress, and inflammation in epileptogenesis
Üstündağ, Fümet Duygu; Ünal, İsmail; Üstündağ, Ünsal Veli; Cansız, Derya; Beler, Merih; Alturfan, Ahmet Ata; Tiber, Pınar Mega; Emekli Alturfan, Ebru (Taylor and Francis Ltd., 2023)Zebrafish (Danio rerio) is becoming an increasingly important model in epilepsy research. Pentylenetetrazole (PTZ) is a convulsant agent that induces epileptic seizure-like state in zebrafish and zebrafish embryos and is ... -
Morphine attenuates neurotoxic effects of MPTP in zebrafish embryos by regulating oxidant/antioxidant balance and acetylcholinesterase activity
Cansız, Derya; Üstündağ, Ünsal Veli; Ünal, İsmail; Alturfan, Ahmet Ata; Emekli Alturfan, Ebru (Taylor & Francis Ltd, 2022)Parkinson's disease (PD) is one of the most common neurodegenerative diseases due to the loss of dopaminergic neurons in the midbrain in the substantia nigra. 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) is a ... -
Rifampicin decreases neuroinflammation to maintain mitochondrial function and calcium homeostasis in rotenone-treated zebrafish
Yurtsever, İlknur; Üstündağ, Ünsal Veli; Ünal, İsmail; Ateş, Perihan Seda; Emekli Alturfan, Ebru (Taylor & Francis Ltd, 2022)Among the mechanisms underlying Parkinson’s disease, many pathogenic mechanisms are suggested to be effective such as oxidative stress, mitochondrial dysfunction, disruption of the ubiquitin-proteasome system, and ... -
Stevioside ameliorates hyperglycemia and glucose intolerance, in a diet-induced obese zebrafish model, through epigenetic, oxidative stress and inflammatory regulation
Dandin, Esra; Üstündağ, Ünsal Veli; Ünal, İsmail; Ateş Kalkan, Perihan Seda; Cansız, Derya; Beler, Merih; Ak, Esin; Alturfan, A. Ata; Emekli Alturfan, Ebru (Elsevier Ltd, 2022)Obesity is an independent risk factor for type 2 diabetes and epigenetic regulatory mechanisms affect obesityrelated mechanisms. Due to weight gain concern in society, artificial sweeteners with no nutritional value have ... -
Stevioside improves brain oxidant-antioxidant status in overfed zebrafish
Dandin, Esra; Ünal, İsmail; Beler, Merih; Üstündağ, Ünsal Veli; Cansız, Derya; Ateş Kalkan, Perihan Seda; Emekli Alturfan, Ebru (Istanbul University Press, 2023)Objective: An excessive buildup of adipose tissue is a defining feature of overnutrition, and a significant fraction of the world's population suffers from obesity. Overnutrition is associated with the deterioration of ... -
Tissue factor and vascular endothelial growth factor in detecting thromboembolic complications in diabetic atherosclerotic patients
Alkan Bozkaya, Tijen; Ateş, Şanser; Üstündağ, Ünsal Veli; Çakıcı, Çağrı; Keskin, İlknur; Yiğit, Pakize; Yiğitbaşı, Ahmet; Emekli, Nesrin (Sage Publications Ltd, 2023)BackgroundAtherosclerosis, which is one of the leading causes of death all over the world, can create major or minor thromboembolic complications with the exponentially increasing diabetic status. Despite all the studies, ...