ORCID "0000-0002-9354-0000" Makale Koleksiyonu için listeleme
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An alternative approach wound healing field with polypodium vulgare
Batur, Şebnem; Ayla, Şule; Şakul, Ayşe Arzu; Okur, Mehmet Evren; Karadağ, Ayşe Esra; Daylan, Benay; Özdemir, Ekrem Musa; Kepil, Nuray; Günal, Mehmet Yalçın (Logos Medical Publishing, 2020)Objective: In this study, we examined the effects of Polypodium vulgare L. (Polypodiaceae) as a candidate to be used for wound healing scarred area. We investigated the antibacterial, and antioxidant activity of P. Vulgare ... -
Antioxidant SMe1EC2 modulates pentose phosphate pathway and glutathione-dependent enzyme activities in tissues of aged diabetic rats
Ulusu, Nuray Nuriye; Gök, Müslüm; Sayın Şakul, Arzu Ayşe; Arı, Nuray; Stefek, Milan; Karasu, Çimen (Slovak Toxicology Society, 2017)The pentose phosphate pathway and glutathione-associated metabolism are the main antioxidant cellular defense systems. This study investigated the effects of the powerful antioxidant SMe1EC2 (2-ethoxycarbonyl-8-methoxy-2 ... -
Arctium minus metanol ekstresinin çeşitli kanser hücre hatları üzerinde sitotoksik etkileri
Sayın Şakul, Ayşe Arzu; Yozgat Byrne, Yasemin; Karadağ, Ayşe Esra; Altınalan, Ebrar; Çimen, Şeyma; Okur, Mehmet Evren (Ankara Üniversitesi, 2022)Amaç: Bu çalışmada Arctium minus (Hill) Bernh. ssp. minus’un toprak üstü kısımlarından elde edilen metanol ekstresinin kanser hücre hatları üzerindeki sitotoksik etkilerinin değerlendirilmesi amaçlanmıştır. Gereç ve ... -
Association of diabetes, hypertension, and their combination with basal symptoms and treatment responses in overactive bladder patients
Müderrisoğlu, A. Elif; Sakul, Ayse A.; Murgas, Sandra; de la Rosette, Jean J. M. C. H.; Michel, Martin C. (Frontiers Media S.A., 2023)Introduction: Pelvic hypoperfusion caused by atherosclerosis has been proposed as a cause of lower urinary tract dysfunction including overactive bladder syndrome (OAB). Limited data indicate that OAB patients with concomitant ... -
Beta-sitosterol and its antinociceptive mechanism action
Şakul, Ayşe Arzu; Okur, Mehmet Evren (Ankara University, 2022)Objective: In this study, the possible central antinociceptive activity of beta-sitosterol is investigated along with its association of stimulation of opioidergic, serotonergic, adrenergic, and cholinergic receptors to ... -
Can volumetric analysis of the brain help diagnose isolated optic neuritis?
Sayın Şakul, Ayşe Arzu; Pençe, Kadriye Betül; Örmeci, Tuğrul; Günal, Mehmet Yalçın (Wiley, 2023)Isolated optic neuritis is a single episode inflammatory optic neuropathy. This condition, which affects the optimal function of the optic nerve, is not associated with neurological or systemic diseases. Our study aimed ... -
Comparison of the efficacy of vestibular rehabilitation and pharmacological treatment in benign paroxysmal positional vertigo
Ata, Görkem; Şakul, Ayşe Arzu; Kılıç, Gamze; Çelikyurt, Cengiz (Springer, 2023)Aim: The aim of the study is to compare the effects of vestibular rehabilitation and pharmacological treatment in benign paroxysmal positional vertigo (BPPV). Materials and methods: Thirty patients (40.93 ± 8.66 years old) ... -
Effects of foeniculum vulgare essential oil compounds, fenchone and limonene, on experimental wound healing
Keskin, İlknur; Günal, Mehmet Yalçın; Ayla, Şule; Kolbaşı, Bircan; Sayın Şakul, Arzu Ayşe; Kılıç, Ülkan; Gök, Özlem; Köroğlu, Kutay M.; Özbek, Hanefi (Taylor and Francis Ltd, 2017)We investigated the wound healing efficacy of the Foeniculum vulgare compounds, fenchone and limonene, using an excisional cutaneous wound model in rats. An excision wound was made on the back of the rat and fenchone and ... -
Evaluation of anatomoradiological findings on trigeminal neuralgia patients using computed tomography and cone-beam computed tomography
Aksoy, Seçil; Sayın Şakul, Arzu; Görür, Durmuş İlker; Şakul, Bayram Ufuk; Orhan, Kaan (Multidisciplinary Digital Publishing Institute(MDPI), 2022)The study aimed to establish and evaluate anatomoradiological landmarks in trigeminal neuralgia patients using computed tomography (CT) and cone-beam CT. CT images of 40 trigeminal neuralgia (TN) and 40 healthy individuals ... -
A highly bioavailable curcumin formulation ameliorates inflammation cytokines and neurotrophic factors in mice with traumatic brain injury
Şakul, Ayşe Arzu; Balçıkanlı, Zeynep; Ateş Özsoy, Nilay; Orhan, Cemal; Şahin, Nurhan; Tuzcu, Mehmet; Juturu, Vijaya; Kılıç, Ertuğrul; Şahin, Kazım (John Wiley and Sons Inc, 2024)A novel curcumin formulation increases relative absorption by 46 times (CurcuWIN®) of the total curcuminoids over the unformulated standard curcumin form. However, the exact mechanisms by which curcumin demonstrates its ... -
HPTLC quantification, assessment of antioxidant potential and in vivo hypoglycemic activity of Scorzonera latifolia (Fisch. & Mey.) DC and its major compounds
Kırmızı Sönmez, Neriman İpek; Bahadır Acıkara, Özlem; Şakul, Ayşe Arzu; Bahtiyar, Bade Cevriye; Bardakçı, Hilal; Barak, Timur Hakan; Özbek, Hanefi (Elsevier B.V., 2022)Scorzonera L. (Asteraceae) species have long been the topic of many phytochemical, analytical, and biological studies since various species of the Scorzonera genus have been widely used as food and medicinal purposes. Apart ... -
In vivo wound-healing and in vitro antibacterial and antioxidant of Carduus extract
Şakul, Ayşe Arzu; Ayla, Şule; Okur, Mehmet Evren; Karadağ, Ayşe Esra; Daylan, Benay; Güzel, Elif; Özdemir, Ekrem Musa; Günal, Mehmet Yalçın (Marmara University, 2023)Carduus adpressus has been used for its anti-hair loss effect in traditional folk medicine. The plant species is mainly distributed in Turkiye, Bulgaria, and the Western Caucasus. The studies on this specific plant in the ... -
In vivo wound-healing and in vitro antibacterial and antioxidant properties of Carduus adpressus extract
Şakul, Ayşe Arzu; Ayla, Şule; Okur, Mehmet Evren; Karadağ, Ayşe Esra; Daylan, Benay; Güzel, Elif; Özdemir, Ekrem Musa; Günal, Mehmet Yalçın (Marmara University, 2023)Carduus adpressus has been used for its anti-hair loss effect in traditional folk medicine. The plant species is mainly distributed in Türkiye, Bulgaria, and the Western Caucasus. The studies on this specific plant in the ... -
İlaç ve gıda takviyelerinin içerikleri hakkında kullanıcıların bilgi ve talep düzeyinin ölçülmesi
Özcan, Vildan; Şakul, Ayşe Arzu; Özbek, Hanefi (Refik Saydam National Public Health Agency (RSNPHA), 2022)İlaçların ve gıda takviyelerinin prospektüslerine bakıldığında içeriklerinin kullanıcıya tam olarak aksettirilmediği görülmektedir. Bu nedenle ilaç veya gıda takviyesi kullanacak kişi, bunların içeriğinde kendi inanç ... -
Preclinical evaluation of scorzonera sp root extracts and major compounds against acute hepatotoxicity induced by carbon tetrachloride
Özbek, Hanefi; Bahadır Acıkara, Özlem; Keskin, İlknur; Kırmızı, Neriman İpek; Yiğitbaşı, Türkan; Sakul, Ayşe Arzu; İşcan, Gülçin Saltan (Wolters Kluwer Medknow Publications, 2017)Evaluation of hepatoprotective activities of Scorzonera roots and their major compounds, was aimed in current study. Scorzonera latifolia, S. tomentosa, S. mollis ssp. szowitsii, S. parviflora and S. cana var. jacquiniana ... -
Protective effect of lutein/zeaxanthin isomers in traumatic brain injury in mice
Günal, Mehmet Yalçın; Şakul, Ayşe Arzu; Çağlayan, Ahmet Burak; Erten, Füsun; Durmaz Kurşun, Öznur Ece; Kılıç, Ertuğrul; Şahin, Kazım (Springer, 2021)Previous studies revealed that oxidative stress and inflammation are the main contributors to secondary injury after traumatic brain injury (TBI). In an earlier study, we reported that lutein/zeaxanthin isomers (L/Zi) exert ... -
A pyridoindole antioxidant SMe1EC2 regulates contractility, relaxation ability, cation channel activity, and protein-carbonyl modifications in the aorta of young and old rats with or without diabetes mellitus
Sayın Şakul, Arzu; Arı, Nuray; Sotnikova, Ruzenna; Ozansoy, Gülgün; Karasu, Çimen (Springer, 2018)We studied the effects of treatment with SMe1EC, a hexahydropyridoindole antioxidant, on vascular reactivity, endothelial function, and oxidonitrosative stress level of thoracic aorta in young and old rats with or without ... -
Specific alterations in the circulating levels of the SIRT1, TLR4, and IL7 proteins in patients with dementia
Kılıç, Ülkan; Elibol, Birsen; Uysal, Ömer; Kılıç, Ertuğrul; Yuluğ, Burak; Sayın Şakul, Arzu; Babacan Yıldız, Gülşen (Pergamon Elsevier Science Ltd, 2018)Sirtuins have gained considerable attention as epigenetic regulators for slowing aging and age-related disorders. The growing association between neurodegeneration and inflammation has led researchers to investigate ... -
Squalene attenuates the oxidative stress and activates AKT/mTOR pathway against cisplatin-induced kidney damage in mice
Sakul, Arzu; Ozansoy, Mehmet; Elibol, Birsen; Ayla, Şule; Günal, Mehmet Yalçın; Yozgat, Yasemin; Basağa, Hüveyda; Şahin, Kazım; Kazancıoğlu, Rümeyza; Kılıç, Ulkan (Tubitak Scientific & Technical Research Council Turkey, 2019)The clinical use of cisplatin, which is a first-line anticancer agent, is highly restricted due to its adverse effects on kidneys that lead to nephrotoxicity. Therefore, some potential reno-protective substances have been ... -
Wound healing activity of arum maculatum
Arzu Şakul, Ayşe; Okur, Mehmet Evren; Ayla, Şule; Daylan, Benay; Karadağ, Ayşe Esra; Batur, Şebnem; Özdemir, Ekrem Musa; Altınalan, Ebrar; Günal, Mehmet Yalçın (Istanbul Medeniyet University, 2023)Objective: In this study, the antioxidant properties of Arum maculatum plant were evaluated. This study reported for the first time the wound healing activity of the methanol extract of A. maculatum fruits. This study aimed ...