ORCID "0000-0002-8814-7351" Makale Koleksiyonu için listeleme
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Biochemical and proteomic analysis of a potential anticancer agent: Palladium(II) saccharinate complex of terpyridine acting through double strand break formation
Adıgüzel, Zelal; Baykal, Ahmet Tarık; Kaçar, Ömer; Yılmaz, Veysel Turan; Ulukaya, Engin; Açılan, Ceyda (American Chemical Society, 2014)Metal based chemotherapeutic drugs are widely used as an effective method to defeat various cancers. In this study, the mechanism of action of a novel therapeutic agent, [Pd(sac)(terpy)](sac)center dot 4H(2)O (sac = ... -
Data for a proteomic analysis of p53-independent induction of apoptosis by bortezomib
Yerlikaya, Azmi; Okur, Emrah; Baykal, Ahmet Tarık; Acılan, Ceyda; Boyacı, İhsan; Ulukaya, Engin (Elsevier, 2014)This data article contains data related to the research article entitled, "A proteomic analysis of p53-independent induction of apoptosis by bortezomib in 4T1 breast cancer cell line" by Yerlikaya et al. [1]. The research ... -
Deneysel çalışmalarda çevresel değişikliğe maruz kalan Fasciola Hepatica'nın salgıladığı protein miktarlarının bir ileri proteomik yaklaşımla incelenmesi
Haçarız, Orçun; Baykal, Ahmet Tarık (Türkiye Parazitoloji Derneği, 2014)Amaç: Ana konakçıdan çıkarıldıktan sonra çevresel değişikliğe maruz kalan Fasciola hepatica'nın salgıladığı protein miktarlarını bir ileri proteomik yaklaşımla incelemek.Yöntemler: Son konakçıdan toplanan ergin F. hepatica ... -
Evaluation of apoptotic molecular pathways for smooth muscle cells isolated from thoracic aortic aneurysms in response to oxidized sterols
Adıgüzel, Zelal; Arda, Nazlı; Kaçar, Ömer; Serhatlı, Müge; Gezer Taş, Serpil; Baykal, Ahmet Tarık; Baysal, Kemal; Açılan, Ceyda (Springer, 2014)Oxysterols, oxygenated derivatives of cholesterol, are found abundantly in the plasma and atherosclerotic plaques, a common risk factor for thoracic aortic aneurysms (TAAs). Among the oxysterols, namely 7-ketocholesterol ... -
Generating a detailed protein profile of Fasciola hepatica during the chronic stage of infection in cattle
Haçarız, Orçun; Baykal, Ahmet Tarık; Akgün, Mete; Kavak, Pınar; Sağıroğlu, Mahmut Şamil; Sayers, Gearoid Patrick (Wiley-Blackwell, 2014)Fasciola hepatica is a trematode helminth causing a damaging disease, fasciolosis, in ruminants and humans. Comprehensive proteomic studies broaden our knowledge of the parasite's protein profile, and provide new insights ... -
Hepatitis B virus e antigen (HBeAg) may have a negative effect on dendritic cell generation
Hatipoğlu, İbrahim; Ercan, Duygu; Açılan, Ceyda; Başalp, Aynur; Durali, Deniz; Baykal, Ahmet Tarık (Elsevier, 2014)Hepatitis B virus (HBV) continues to be a serious worldwide health problem despite the use of protective HBV vaccines and therapeutic regimens against chronic HBV infection. Chronic HBV patients cannot induce sufficient ... -
Identification of ApoA1, HPX and POTEE genes by omic analysis in breast cancer
Çine, Naci; Baykal, Ahmet Tarık; Sünnetçi, Deniz; Cantürk, Zafer; Serhatlı, Müge; Savlı, Hakan (Spandidos Publications, 2014)Breast cancer is the most common cancer among women and accounts for 23% of all female types of cancers. It is well recognized that breast cancer represents a heterogeneous group of tumors, and the molecular events involved ... -
mTor Is a signaling hub in cell survival: A mass-spectrometry-based proteomics investigation
Tang, Zhi; Baykal, Ahmet Tarık; Gao, Hui; Quezada, Hernan Concha; Zhang, Haiyan; Bereczki, Erika; Serhatlı, Müge; Baykal, Betül; Acıoğlu, Çiğdem; Wang, Shan; Ioja, Eniko; Ji, Xinying; Zhang, Yan; Guan, Zhizhong; Winblad, Bengt; Pei, Jin-Jing (American Chemical Society, 2014)mTor plays a central role in controlling protein homeostasis and cell survival. Recently, we have demonstrated that perturbations of mTor signaling are implicated in Alzheimer's disease (AD) and that mTor complex 1 (mTorC1) ... -
A preliminary proteomic evaluation of smooth muscle cells in thoracic aortic aneurysms
Açılan Ayhan, Ceyda; Baykal, Betül; Serhatlı, Müge; Kaçar, Ömer; Adıgüzel, Zelal; Taş, Serpil; Baysal, Kemal; Baykal, Ahmet Tarık (The Scientific and Technological Research Council of Turkey, 2014)Aortic aneurysm is characterized as localized degeneration of the aorta leading to advanced weakening and widening of the vessel. While the exact mechanisms have yet to be determined, current studies indicate that the ... -
A proteomic analysis of p53-independent induction of apoptosis by bortezomib in 4T1 breast cancer cell line
Yerlikaya, Azmi; Okur, Emrah; Baykal, Ahmet Tarık; Acılan, Ceyda; Boyacı, İhsan; Ulukaya, Engin (Elsevier Science, 2015)The 26S proteasome is a proteolytic enzyme found in both cytoplasm and nucleus. In this study, we examined the differential expression of proteasome inhibitor bortezomib-induced proteins in p53-deficient 4T1 cells. It was ... -
Proteomic study of the microdissected aortic media in human thoracic aortic aneurysms
Serhatlı, Müge; Baysal, Kemal; Açılan, Ceyda; Tuncer, Eylem; Bekpınar, Seldağ; Baykal, Ahmet Tarık (American Chemical Society, 2014)Aortic aneurysm is a complex multifactorial disease, and its molecular mechanism is not understood. In thoracic aortic aneurysm (TAA), the expansion of the aortic wall is lead by extracellular matrix (ECM) degeneration in ...