ORCID "0000-0002-7129-5024" Makale Koleksiyonu için listeleme
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Chronic neutropenia in childhood: Laboratory and clinical features
Nepesov, Serdar; Yaman, Yöntem; Elli, Murat; Bayram, Nihan; Özdilli, Kürşat; Ayaz, Akif; Anak, Sema (Springer India, 2022)Objectives To describe the clinical characteristics of patients with chronic neutropenia. Methods Data of 36 patients with chronic neutropenia, who were followed up in the authors' clinic between May 2013 and May 2020, ... -
Clinical efficacy of ruxolitinib monotherapy and haploidentical hematopoeitic stem cell transplantation in a child with philadelphia chromosome-like relapsed/refractory acute lymphoblastic leukemia
Bayram, Nihan; Yaman, Yöntem; Özdilli, Kürşat; Telhan, Leyla; Nepesov, Serdar; Bilgen, Hülya; Elli, Murat; Behar, Sude Sema; Anak, Sema (Wiley, 2021)Introduction (Ph-like) ALL is a subset of leukemia which has a gene expression profile similar to Ph+disease, but without the presence of BCR-ABL1 translocation. Case description We reported an exceptional case of a ... -
Clinical, genetic, and outcome characteristics of pediatric patients with primary hemophagocytic lymphohistiocytosis
Nepesov, Serdar; Yaman, Yöntem; Elli, Murat; Bayram, Nihan; Özdilli, Kürşat; Kıykım, Ayça; Çakır, Deniz; Kılıç, Betül; Aydın, Kürşad; Ayaz, Akif; Telhan, Leyla; Anak, Sema (AVES, 2022)Objectİive: In this study, we sought to describe the clinical, laboratory, and genetic characteristics of patients diagnosed with primary hemophagocytic lymphohistiocytosis. Thus, we aimed to evaluate the early diagnosis ... -
Cytokine gene polymorphism frequencies in Turkish population living in Marmara region
Özdilli, Kürşat; Duvarcı Öğret, Yeliz; Oğuz, Süleyman Rüştü; Abatay Sel, Figen; Şentürk Çiftçi, Hayriye; Kekik Çınar, Çiğdem; Pehlivan, Sacide; Savran Oğuz, Fatma (De Gruyter Open Ltd, 2022)Objectives Sequence variants in cytokine genes are related to affect cytokine gene levels. In this study, it was aimed to examine eight single nucleotide polymorphisms (SNPs) in five cytokine genes (TNF-alpha, INF-gamma, ... -
Determination of burnout and job satisfaction levels in nurses working in the surgical clinics
Objective: The aim of this study was to assess the effect of sociodemographic and professional characteristics of nurses working in thesurgical services on their burnout and job satisfaction levels.Method: The study was ... -
Effect of cytokine genes in the pathogenesis and on the clinical parameters for the treatment of multiple myeloma
Haydaroğlu, Handan; Oğuzkan Balcı, Sibel; Pehlivan, Sacide; Özdilli, Kürşat; Gündoğan, Ersin; Okan, Vahap; Nursal, Ayşe Feyda; Pehlivan, Mustafa (Taylor & Franis Ltd, 2017)In this study, we aimed to explore the association among gene variants of five cytokines, tumor necrosis factor alpha (TNF-alpha), transforming growth factor beta-1 (TGF-beta 1), interferon gamma (IFN-gamma), interleukin-6 ... -
Eltrombopag for treatment of thrombocytopenia after allogeneic hematopoietic cell transplantation in children: Single-centre experience
Yaman, Yöntem; Elli, Murat; Şahin, Şifa; Özdilli, Kürşat; Bilgen, Hülya; Bayram, Nihan; Nepesov, Serdar; Anak, Sema (Wiley, 2021)Delayed recovery of thrombocytopenia is a well-known complication after allogeneic HSCT. Eltrombopag (ELT), a thrombopoietin receptor agonist (TRAs), induces platelet maturation and release. Mostly conducted in adults, ... -
Evaluation of gene-gene interaction between the interleukin (IL)-2 and IL-2RA gene polymorphisms in schizophrenia patients in the Turkish Population
Özdilli, Kürşat; Aytaç, Hasan Mervan; Tuncel, Fatima Ceren; Oyacı, Yasemin; Pehlivan, Mustafa; Pehlivan, Sacide (2024)OBJECTIVES: To evaluate the genetic polymorphisms in IL-2 and IL-2RA genes in schizophrenia (SCZ) patients by comparing them with healthy controls. METHODS: A sample of 127 patients with SCZ and 100 healthy volunteers were ... -
Gene polymorphisms and febrile neutropenia in acute leukemia-no association with IL-4, CCR-5, IL-1RA, but the MBL-2, ACE, and TLR-4 are associated with the disease in Turkish patients: A preliminary study
Pehlivan, Mustafa; Haydaroğlu Şahin, Handan; Özdilli, Kürşat; Onay, Hüseyin; Özcan, Ali; Özkinay, Ferda; Pehlivan, Sacide (Mary Ann Liebert, Inc., 2014)Aims: The aim of this study was to investigate the mannose-binding lectin 2 (MBL-2), interleukin (IL)-4, Toll-like receptor 4 (TLR-4), angiotensin converting enzyme (ACE), chemokine receptor 5 (CCR-5), and IL-1 receptor ... -
Genetic polymorphisms in 15 STR loci in the Turkish population living in İstanbul province
Özdilli, Kürşat; Duvarcı Öğret, Yeliz; Oğuz, Rüştü; İşsever, Halim; Yokeş, Mehmet Baki; Şentürk Çiftci, Hayriye; Abatay Sel, Figen; Kıvanç, Demet; Kekik Çınar, Çiğdem; Pehlivan, Sacide; Savran Oğuz, Fatma (Nobelmedicus, 2022)Objective: Short tandem repeats (STRs) are short sequences of nucleotides that are repeated and distributed all over the genome. These polymorphisms enable investigation of the forensic, ancestral lineage and evolutionary ... -
Graft-versus-host disease in a child with neuroblastoma after autologous stem cell transplantation
Yaman, Yöntem; Baysoy, Gökhan; Keleşoğlu, Emre; Özdilli, Kürşat; Çakır, Aslı; Genç, Dildar Bahar; Elli, Murat; Anak, Sema (Termedia Publishing House Ltd, 2019)In the pediatric population, hematopoietic stem cell transplantation (HSCT) is used to treat a wide variety of diseases, both malignant and nonmalignant. For many of these diseases, HSCT is a well-established treatment. ... -
Hematopoietic stem cell transplantation in patients with severe combined immunodeficiency: A single-center experience
Nepesov, Serdar; Yaman, Yöntem; Elli, Murat; Bayram, Nihan; Özdilli, Kürşat; Kıykım, Ayça; Anak, Sema (Istanbul University, 2022)Objective: The aim of this study was to determine the factors affecting outcomes in patients who underwent hematopoietic stem cell transplantation (HSCT) with the diagnosis of severe combined immunodeficiency (SCID). ... -
HLA - matched related donor hematopoietic stem cell transplantation in a patient with polynucleotide kinase 3-phosphatase mutation developed acute myeloid leukemia
Bayram, Nihan; Yaman, Yöntem; Elli, Murat; Özdilli, Kürşat; Nepesov, Serdar; Doğan, Mehmet Sait; Ayaz, Akif; Anak, Sema (Wiley, 2022)Background PNPK gene mutations result in DNA repair disorders and have a spectrum of neurodevelopmental manifestations. To date, cancer predisposition has not been described in patients with PNKP mutations. Observation ... -
HLA DRB1 alleles, IFN-gamma and TGF-beta Gene Variants in childhood ALL patients
Oğuz, Süleyman Rüştü; Şentürk Çiftçi, Hayriye; Gökçe, Müge; Öğret, Yeliz; Kıvanç, Demet; Özdilli, Kürşat; Atay, Avni; Savran Oğuz, Fatma; Aydın, Filiz (Walter de Gruyter GmbH, 2023)Objectives Graft-versus-host disease (GvHD) is a complex clinical syndrome with organ dysfunction as a consequence of a severe immunological reaction mediated by mainly T cells after hematopoietic stem cell transplantation. ... -
Hodgkin lenfoma nüks ve/veya kemoterapi dirençli olgularda hematopoetik kök hücre nakli ve yüksek doz kemoterapi: Tek merkez deneyimi
Yaman, Yöntem; Elli, Murat; Özdilli, Kürşat; Telhan, Leyla; Bayram, Nihan; Hazar, Volkan; Tuprul Sarıbeyoğlu, Ebru; Şahin, Şifa; Anak, Sema (İstanbul Üniversitesi, 2021)Giriş: Standart tedavi alan Hodgkin Lymphoma (HL) hastalarının yaklaşık %20’sinde hastalık dirençli seyredebilir veya tekrar edebilir. Tekrar eden/ dirençli HL’da standart tedavi yüksek doz kemoterapi ve takip eden otolog ... -
The influence of human leukocyte antigens in graft versus host disease and survival after hematopoietic stem cell transplantation in pediatric patients with leukemia
Özdilli, Kürşat; Savran Oğuz, Fatma; Anak, Sema; Öğret, Yeliz; Şentürk Çiftçi, Hayriye; Rüştü, Oğuz; Çarin, Mahmut (Galenos Publishing House, 2021)Objective: Hematopoietic stem cell transplantation (HSCT) is an important therapy for hematological diseases. One of the most significant complications of HSCT is graft versus host disease (GVHD), and major histocompatibility ... -
The mir-196a2t/c variant as a possible predisposing factor for ankylosing spondylitis in a Turkish population2
Pehlivan, Sacide; Gürsoy, Savaş; Nursal, Ayşe Feyda; Akaltun, Mazlum Serdar; Özdilli, Kürşat; Pehlivan, Mustafa (Istanbul University Publisher, 2020)Objective: Ankylosing spondylitis (AS) is a chronic inflammatory disorder. MicroRNAs (miRNAs) can function as either oncogenes or tumor suppressor genes. Altered miRNA expression has been implicated in the pathogenesis of ... -
Prognostic importance of single-nucleotide polymorphisms in IL-6, IL-10, TGF-beta 1, IFN-gamma, and TNF-alpha genes in chronic phase chronic myeloid leukemia
Pehlivan, Mustafa; Haydaroğlu Şahin, Handan; Pehlivan, Sacide; Özdilli, Kürşat; Kaynar, Leylagül; Savran Oğuz, Fatma; Sever, Tuğçe; Yılmaz, Mehmet; Eser, Bülent; Duvarcı Öğret, Yeliz; Kis, Cem; Okan, Vahap; Çetin, Mustafa; Carin, Mahmut (Mary Ann Liebert, Inc, 2014)The aim of this study was to explore the association between polymorphisms of five cytokine genes and clinical parameters in patients with Philadelphia-positive (Ph+) chronic myeloid leukemia (CML) treated with imatinib. ... -
Tumor necrosis factor-alpha (TNF-alpha)-238 G/A polymorphism is associated with the treatment resistance and attempted suicide in schizophrenia
Aytaç, Hasan Mervan; Özdilli, Kürşat; Tuncel, Fatıma Ceren; Pehlivan, Mustafa; Pehlivan, Sacide (Taylor & Francis Ltd, 2022)Abnormality of the immune system may play an important role in the pathogenesis of schizophrenia (SCZ). We aim to investigate the relationship between clinical features of SCZ and tumor necrosis factor-alpha (TNF-α) -238 ...