ORCID "0000-0002-2306-5937" Makale Koleksiyonu için listeleme
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Altered blood parameters in “major depression” patients receiving repetitive transcranial magnetic stimulation (rTMS) therapy: a randomized case-control study
Özkan, Beyza Nur; Bozali, Kübra; Boylu, Muhammed Emin; Velioğlu, Halil Aziz; Aktaş, Selman; Kırpınar, İsmet; Güler, Eray Metin (2024)Major depressive disorder (MDD) is a debilitating illness that includes depressive mood. Repetitive Transcranial Magnetic Stimulation (rTMS) is a therapy method used in the treatment of MDD. The purpose of this study was ... -
Clinical evaluation and resting state fMRI analysis of virtual reality based training in Parkinson's disease through a randomized controlled trial
Hajebrahimi, Farzin; Velioğlu, Halil Aziz; Bayraktaroğlu, Zübeyir; Helvacı Yılmaz, Nesrin; Hanoğlu, Lütfü (Nature Research, 2022)There are few studies investigating the short-term effects of Virtual Reality based Exergaming (EG) on motor and cognition simultaneously and pursue the brain functional activity changes after these interventions in patients ... -
Combined metabolic activators improve cognitive functions in Alzheimer's disease patients: A randomised, double-blinded, placebo-controlled phase-II trial
Yuluğ, Burak; Altay, Özlem; Li, Xiangyu; Hanoğlu, Lütfü; Çankaya, Şeyda; Lam, Simon; Velioğlu, Halil Aziz; Yang, Hong; Coşkun, Ebru; İdil, Ezgi; Nogaylar, Rahim; Özşimşek, Ahmet; Bayram, Cemil; Bolat, İsmail; Öner, Sena; Özdemir Tozlu, Özlem; Arslan, Mehmet Enes; Hacimuftüoğlu, Ahmet; Yıldırım, Serkan; Arif, Muhammad; Shoaie, Saeed; Zhang, Cheng; Nielsen, Jens; Türkez, Hasan; Borén, Jan; Uhlén, Mathias; Mardinoglu, Adil (BioMed Central Ltd, 2023)Background: Alzheimer’s disease (AD) is associated with metabolic abnormalities linked to critical elements of neurodegeneration. We recently administered combined metabolic activators (CMA) to the AD rat model and observed ... -
Diabetes-related clinical and microstructural white matter changes in patients with Alzheimer's disease
Aim: Although there exists substantial epidemiological evidence indicating an elevated risk of dementia in individuals with diabetes, our understanding of the neuropathological underpinnings of the association between ... -
Differentiation of claustrum resting-state functional connectivity in healthy aging, Alzheimer's disease, and Parkinson's disease
Ayyıldız, Sevilay; Velioğlu, Halil Aziz; Ayyıldız, Behçet; Sütçübaşı, Bernis; Hanoğlu, Lütfü; Bayraktaroğlu, Zübeyir; Yıldırım, Süleyman; Atasever, Alper; Yuluğ, Burak (Wiley, 2023)The claustrum is a sheet-like of telencephalic gray matter structure whose function is poorly understood. The claustrum is considered a multimodal computing network due to its reciprocal connections with almost all cortical ... -
DLPF targeted repetitive transcranial magnetic stimulation improves brain glucose metabolism along with the clinical and electrophysiological parameters in CBD patients
Toprak, Güven; Hanoğlu, Lütfü; Çakır, Tansel; Güntekin, Bahar; Velioğlu, Halil Aziz; Yuluğ, Burak (Bentham Science Publishers, 2022)Background: Corticobasal Degeneration (CBD) is a rare neurological disease caused by the pathological accumulation of tau protein. The primary pathological features of CBD include progressive neurodegenerative processes ... -
EGb 761 reduces Ca2+ influx and apoptosis after pentylenetetrazole treatment in a neuroblastoma cell line
Övey, İshak Suat; Özşimşek, Ahmet; Velioğlu, Halil Aziz; Altay, Özlem; Mardinoğlu, Adil; Yuluğ, Burak (Frontiers Media SA, 2023)Background: Transient receptor potential (TRP) channels have been found to have significant implications in neuronal outgrowth, survival, inflammatory neurogenic pain, and various epileptogenic processes. Moreover, there ... -
Infection with COVID-19 is no longer a public emergency: But what about degenerative dementia?
Yuluğ, Burak; Ayyıldız, Behçet; Ayyıldız, Sevilay; Sayman, Dila; Salar, Ali Behram; Çankaya, Şeyda; Özdemir, Ece; Özşimşek, Ahmet; Kurt, Çağla Ceren; Lakadamyalı, Hatice; Aktürk, Aynur; Altay, Özlem; Hanoğlu, Lütfü; Velioğlu, Halil Aziz; Mardinoğlu, Adil (John Wiley and Sons Inc, 2023)Although no longer considered a public health threat, post-COVID cognitive syndrome continues to impact on a considerable proportion of individuals who were infected with COVID-19. Recent studies have also suggested that ... -
Left lateral parietal rTMS improves cognition and modulates resting brain connectivity in patients with Alzheimer's disease: Possible role of BDNF and oxidative stress
Velioğlu, Halil Aziz; Hanoğlu, Lütfü; Bayraktaroğlu, Zübeyir; Toprak, Güven; Güler, Eray Metin; Bektay, Muhammed Yunus; Mutlu Burnaz, Özlem; Yuluğ, Burak (Academic Press Inc., 2021)Repetitive Transcranial Magnetic Stimulation (rTMS) is a non-invasive neuromodulation technique which is increasingly used for cognitive impairment in Alzheimer?s Disease (AD). Although rTMS has been shown to modify ... -
Neuroimaging-guided transcranial magnetic and direct current stimulation in MCI: Toward an individual, effective and disease-modifying treatment
Hanoğlu, Lütfü; Velioğlu, Halil Aziz; Hanoğlu, Taha; Yuluğ, Burak (SAGE Publications Inc, 2023)The therapeutic approaches currently applied in Alzheimer's disease (AD) and similar neurodegenerative diseases are essentially based on pharmacological strategies. However, despite intensive research, the effectiveness ... -
Paracetamol alters empathy scores in healthy and headache subjects: Functional MRI correlates
Çankaya, Şeyda; Özdemir Öktem, Ece; Saatçi, Özlem; Velioğlu, Halil Aziz; Uygur, Abdullah Burak; Özşimşek, Ahmet; Hanoğlu, Lütfü; Yuluğ, Burak (Elsevier Science Ltd., 2020)Introduction: Although previous evidence suggest that paracetamol decreases psychological reactivity in healthy subjects, there is still no confirmed correlation between the empathy scores and brain activity in healthy and ... -
Predicting the effects of repetitive transcranial magnetic stimulation on cognitive functions in patients with alzheimer's disease by automated EEG analysis
Kayasandık, Cihan Bilge; Velioğlu, Halil Aziz; Hanoğlu, Lütfü (Frontiers Media SA, 2022)Alzheimer's disease (AD) is a progressive, neurodegenerative brain disorder that generally affects the elderly. Today, after the limited benefit of the pharmacological treatment strategies, numerous noninvasive brain ... -
Repetitive transcranial magnetic stimulation improves hippocampal n-acetlaspartate levels and visual memory scores in alzheimer's disease
Velioğlu, Halil Aziz; Sayman, Dila; Hanoğlu, Lütfü; Ertan Akan, Gülhan; Çankaya, Şeyda; Yuluğ, Burak (2024)The latest research into the pathophysiology of Alzheimer's Disease (AD) has included several cognitive deficits related to hippocampal functioning. However, current clinical research fails to consider the full extent of ... -
rTMS reduces delta and increases theta oscillations in Alzheimer's disease: A visual-evoked and event-related potentials study
Velioğlu, Halil Aziz; Düdükçü, Esra Zeynep; Hanoğlu, Lütfü; Güntekin, Bahar; Aktürk, Tuba; Yuluğ, Burak (Wiley, 2024)Background: Repetitive transcranial magnetic stimulation (rTMS) has emerged as a promising alternative therapy for Alzheimer's disease (AD) due to its ability to modulate neural networks and enhance cognitive function. ... -
Stratification of the gut microbiota composition landscape across the alzheimer's disease continuum in a Turkish cohort
Yıldırım, Süleyman; Nalbantoğlu, Özkan Ufuk; Bayraktar, Abdulahad; Ercan, Fatma Betül; Gündoğdu, Aycan; Velioğlu, Halil Aziz; Göl, Mehmet Fatih; Ekinci Soylu, Ayten; Koç, Fatma; Aslan Gülpınar, Ezgi; Soğukkanlı Kadak, Kübra; Arıkan, Muzaffer; Mardinoğlu, Adil; Koçak, Mehmet; Köseoğlu, Emel; Hanoğlu, Lütfü (American Society for Microbiology, 2022)Alzheimer's disease (AD) is a heterogeneous disorder that spans a continuum with multiple phases, including preclinical, mild cognitive impairment, and dementia. Unlike for most other chronic diseases, human studies reporting ... -
A structural and resting-state functional connectivity investigation of the pulvinar in elderly individuals and Alzheimer's disease patients
Velioğlu, Halil Aziz; Ayyıldız, Behçet; Ayyıldız, Sevilay; Sütçübaşı, Bernis; Hanoğlu, Lütfü; Bayraktaroğlu, Zübeyir; Yuluğ, Burak (John Wiley and Sons Inc, 2023)In Alzheimer's disease (AD), structural and functional changes in the brain may give rise to disruption of specific cognitive functions. The aim of this study is to investigate the functional connectivity alterations in ... -
Topological network mechanisms of clinical response to antidepressant treatment in drug-naive major depressive disorder
Uykur, Abdullah Burak; Yıldız, Sultan; Velioğlu, Halil Aziz; Özşimşek, Ahmet; Özdemir Öktem, Ece; Bayraktaroğlu, Zübeyir; Ergün, Tarkan; Lakadamyalı, Hatice; Hanoğlu, Lütfü; Çankaya, Şeyda; Saatçi, Özlem; Yuluğ, Burak (Elsevier Ltd, 2021)Aim: There is rapidly increasing evidence that remission of MDD is associated with substantial changes in functional brain connectivity. These New data have provided a holistic view on the mechanism of antidepressants on ...