Yazar "İşyar, Mehmet" için Makale Koleksiyonu listeleme
-
Are biological agents toxic to human chondrocytes and osteocytes?
İşyar, Mehmet; Bilir, Bülent; Yılmaz, İbrahim; Çakmak, Selami; Yaşar Şirin, Duygu; Yıldırım Güzelant, Aliye; Mahiroğulları, Mahir (BioMed Central, 2015)Purpose: The aim of the present study is to investigate the effects of biological agents (BAs) on human chondrocytes and osteocytes in vitro. Methods: Primary cell cultures obtained from gonarthrosis patients were divided ... -
Are chondrocytes damaged when rheumatologic inflammation is suppressed?
Yıldırım Güzelant, Aliye; İşyar, Mehmet; Yılmaz, İbrahim; Yaşar Şirin, Duygu; Çakmak, Selami; Mahiroğulları, Mahir (Taylor & Francis Inc, 2017)Aim: The use of biological agents (BAs) for treating diseases such as rheumatoid arthritis (RA), spondyloarthropathy, and systemic lupus erythematosus to reduce inflammation has been fruitful. Especially as part of the ... -
Are we economically efficient enough to ıncrease the potential of in vitro proliferation of osteoblasts by means of pharmacochemical agents?
İşyar, Mehmet; Gümüştaş, Seyit Ali; Yılmaz, İbrahim; Yaşar Şirin, Duygu; Tosun, Hacı Bayram; Mahiroğulları, Mahir (Bentham Open, 2016)Background: The aim of this study was to test the necessity of using expensive and unaccesible pharmacological-chemical agents in the proliferation of bone tissue cultures and in the induction of mineralized matrix formation ... -
Are we using slow-acting symptomatic chondroprotective drugs conscious enough?
Gümüştaş, Seyit Ali; Öznam, Kadir; Mutlu, Çağrı Ata; Kaya, Yasin Emre; Yılmaz, İbrahim; İşyar, Mehmet; Yıldırım Güzelant, Aliye; Güler, Olcay; Akkaya, Semih; Mahiroğulları, Mahir (Bentham Open, 2017)Background: Osteochondral injuries constitute an entity that is widespread and can be seen in patients of all ages. Actual treatment modalities aim to relieve pain, obtain full range of movement of the joint, and improve ... -
Assessing the negative impact of phenyl alkanoic acid derivative, a frequently prescribed drug for the suppression of pain and inflammation, on the differentiation and proliferation of chondrocytes
Gümüştaş, Seyit Ali; Yılmaz, İbrahim; İşyar, Mehmet; Şirin Yaşar, Duygu; Batmaz, Ahmet Güray; Uğraş, Ali Akın; Öznam, Kadir; Çiftçi, Zafer; Mahiroğulları, Mahir (BMC, 2016)Background: Non-steroidal anti-inflammatory drugs (NSAIDs) are frequently prescribed to relieve pain and inflammation. These NSAIDs have also analgesic effects and can be administered via oral, injectable, and topical ... -
Can a biodegradable implanted bilayered drug delivery system loaded with BMP-2/BMP-12 take an effective role in the biological repair process of bone-tendon injuries? A preliminary report
Kömür, Baran; Akyuva, Yener; Karaslan, Numan; İşyar, Mehmet; Gümüştaş, Seyit Ali; Yılmaz, İbrahim; Akkaya, Semih; Şirin, Duygu Yaşar; Mutlu, Çağri Ata; Batmaz, Ahmet Güray; Güler, Olcay; Mahiroğulları, Mahir (Hindawi Ltd, 2017)Background. Use of biodegradable and biocompatible materials in the orthopedic surgery is gaining popularity. In this research, the rate of controlled release of a bilayered prototype biomaterial designed to promote ... -
Chondrocyte proliferation, viability and differentiation is declined following administration of methylphenidate utilized for the treatment of attention-deficit/hyperactivity disorder
Gümüştaş, Funda; Yılmaz, İbrahim; Yaşar Şirin, Duygu; Gümüştaş, Seyit Ali; Batmaz, Ahmet Güray; İşyar, Mehmet; Akkaya, Şeyda; Mahiroğulları, Mahir (Sage Publications Ltd, 2017)Purpose: Methylphenidate (MPH) derivative drugs are used because of psychostimulants effects on attention-deficit hyperactivity disorder in children and adults. As far as we know, toxic or anti-proliferative effects of MPH ... -
Comparison of quadriceps muscle volume after unilateral total knee arthroplasty with and without tourniquet use
Güler, Olcay; Mahiroğulları, Mahir; İşyar, Mehmet; Pişkin, Ahmet; Yalçın, Sercan; Mutlu, Serhat; Şahin, Bünyamin (Springer, 2016)Determination of the effect of tourniquet use in total knee arthroplasty (TKA) on thigh and quadriceps muscle volume using magnetic resonance imaging (MRI). A total of 148 knees of 74 patients (mean age 66.5 +/- 4.8 years; ... -
Comparison of short-term results of intraarticular platelet-rich plasma (PRP) and hyaluronic acid treatments in early-stage gonarthrosis patients
Güler, Olcay; Mutlu, Serhat; İşyar, Mehmet; Şeker, Ali; Kayaalp, Mahmut Enes; Mahiroğulları, Mahir (Springer-Verlag, 2015)The present study aimed to compare short-term clinical outcomes between intraarticular platelet-rich plasma (PRP) and hyaluronic acid (HA) treatments in early-stage gonarthrosis patients. Data of gonarthrosis patients, who ... -
Does leukocyte-poor or leukocyte-rich platelet-rich plasma applied with biopolymers have superiority to conventional platelet-rich plasma applications on chondrocyte proliferation?
Yaşar Şirin, Duygu; Yılmaz, İbrahim; İşyar, Mehmet; Öznam, Kadir; Mahiroğulları, Mahir (Turkish Joint Diseases Foundation, 2017)Objectives: This study aims to investigate the possible effects of leukocyte concentration in the content of platelet-rich plasma (PRP) and the administration of PRP using a drug delivery system on chondrocyte proliferation ... -
Efficacy of periarticular injection applied trough knee other than posterior capsule in simultaneous bilateral total knee arthroplasty
Güler, Olcay; Mutlu, Serhat; İşyar, Mehmet; Mutlu, Harun; Bülbül, Ahmet Murat; Mahiroğulları, Mahir (Reed Elsevier India, 2015)Background: We aimed to evaluate periarticular multimodal drug injection (PMDI) in bilateral total knee arthroplasty. Methods: In 154 knees of 77 patients, PMDI was administered intraoperatively through the regions other ... -
Evaluating the features of interdigital neuroma using 3-Tesla magnetic resonance imaging
Örmeci, Tuğrul; Güler, Olcay; Malkoç, Melih; Kaya, Nurullah; İşyar, Mehmet; Çakır, Aslı; Şen, Selva; Mahiroğulları, Mahir (Sociedad Anatómica Española, 2023)Interdigital neuroma is an entrapment neurop-athy of the interdigital nerve. Previously, studies on interdigital neuroma were done with 1 Tesla Magnetic Resonance Imaging and more often 1.5 Tesla Magnetic Resonance Imaging. ... -
Evaluation of antibiotic alternatives used in orthopedic departments of 2 hospitals according to rational use of antibiotics
İşyar, Mehmet; Doğan, Mustafa; Gümüştaş, Seyit Ali; Yılmaz, İbrahim; Bilir, Bülent; Güler, Olcay; Saraçoğlu Varol, Gamze; Mahiroğulları, Mahir (Kare Yayıncılık ve İletişim Hizmetleri, 2016)Background: The present study is an analysis of appropriateness of antibiotics use for patients in whom infectious agent was detected. Data from patients in orthopedics and traumatology department of 2 hospitals in the ... -
Evaluation of neutrophil-to-lymphocyte ratio as a marker of inflammatory response in septic arthritis
Bilir, Bülent; İşyar, Mehmet; Yılmaz, İbrahim; Saraçoǧlu, Gamze Varol; Çakmak, Selami; Doǧan, Mustafa; Mahiroğulları, Mahir (Sage Publications, 2015)Is neutrophil-to-lymphocyte ratio high in patients with septic arthritis? Septic arthritis may lead to higher rates of morbidity or even mortality if not diagnosed on time. This study was planned to answer the question ... -
Evaluation of results of conservative therapy in patients with transient osteoporosis of hip
Güler, Olcay; İşyar, Mehmet; Mahiroğulları, Mahir; Özyürek, Selahattin; Çakmak, Selami; Mutlu, Serhat (ARSMB-KVBMG, 2015)The present study aimed to review the general characteristics of 18 cases diagnosed with transient osteoporosis of the hip (TOH) in our hospital within a 3-year period and to present their follow-up results after conservative ... -
Femur neck fracture in young adults, is it really an urgent surgery indication: Retrospective clinical study
Gümüştaş, Seyit Ali; Tosun, Hacı Bayram; İşyar, Mehmet; Serbest, Sancar; Öznam, Kadir; Bulut, Güven (African Field Epidemiology Network-Afenet, 2018)Introduction: Femur neck fracture comprises a significant part of intracapsular femur fracture in the intracapsular area of proximal femur and it is mostly seen in elder people. However, these kinds of fractures may be ... -
Investigating the relationship between internal tibial torsion and medial collateral ligament injury in patients undergoing knee arthroscopy due to tears in the posterior one third of the medial meniscus
Güler, Olcay; İşyar, Mehmet; Karataş, Dilek; Örmeci, Tuğrul; Çerci, Halis; Mahiroğulları, Mahir (Elsevier Science Bv, 2016)Purpose: To evaluate the relationship between medial collateral ligament (MCL) injury and degree of internal tibial torsion in patients who had undergone arthroscopic resection due to tears in the posterior one third of ... -
Iopromide- and gadopentetic acid-derived preparates used in MR arthrography may be harmful to chondrocytes
Öznam, Kadir; Şirin, Duygu Yaşar; Yılmaz, İbrahim; Kaya, Yasin Emre; İşyar, Mehmet; Gümüştaş, Seyit Ali; Özbek, Hanefi; Akkaya, Semih; Kayhan, Arda; Mahiroğulları, Mahir (BMC, 2017)Background: Magnetic resonance arthrography, a procedure through which contrast agents containing gadolinium and/or iopromide are administered intra-articularly, has become a useful tool in musculoskeletal diagnosis. ... -
Is it possible to treat osteosarcoma using oligonucleotides confined into controlled release drug delivery systems?
Topuk, Savaş; Akyuva, Yener; Karaaslan, Numan; Mutlu, Çağri Ata; Yılmaz, İbrahim; İşyar, Mehmet; Şirin, Duygu Yaşar; Akkaya, Semih; Özbek, Hanefi; Mahiroğulları, Mahir (Bentham Science Publishers Ltd, 2017)Purpose: The present study aimed to analyze the researches that are at the experimental phase concerning osteosarcoma treatment. The researches included drug delivery systems which allow controlled release and imbue small ... -
Is there a treatment protocol in which platelet-rich plasma is effective?
Yılmaz, İbrahim; Akkaya, Semih; İşyar, Mehmet; Batmaz, Ahmet Güray; Güler, Olcay; Öznam, Kadir; Uğras, Akın; Mahiroğulları, Mahir (Elsevier Science Bv, 2016)Aim: We aimed to reveal whether there are prospective suggestions for effective and standard platelet-rich plasma applications. Methods: We searched for clinical trials and traced all the references of incorporated documents. ...