ORCID "0000-0003-2003-6337" Makale Koleksiyonu için listeleme
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Evaluation of the expression and proliferation of degenerative markers in primary cell cultures obtained from human intervertebral disc tissue
Kaya, Yasin Emre; Akalan, Hande; Yılmaz, İbrahim; Karaarslan, Numan; Yaşar Şirin, Duygu; Özbek, Hanefi (Annals of Medical Research Publishing Inc, 2020)Aim: A major cause of low back pain is disc degeneration. Nevertheless, no specific and reliable markers of the degeneration of the nucleus pulposus (NP) are available. This presented study aimed to examine changes in the ... -
In-vitro evaluation of the effects of tigecycline on annulus firosus and nucleus pulposus
Kaya, Yasin Emre; Yılmaz, İbrahim; Karaarslan, Numan; Bilir, Bülent; Yaşar Şirin, Duygu; Özbek, Hanefi (Annals of Medical Research Publishing Inc, 2020)Aim: This study aimed to examine the effects of tigecycline on primary cell cultures established using intervertebral disc tissues. Material and Methods: Primary Annulus Fibrosus and Nucleus Pulposus cultures were obtained ... -
Investigation of the effect of dipyrone on cells isolated from intervertebral disc tissue
Akgün, Feride Sinem; Şirin, Duygu Yaşar; Yılmaz, İbrahim; Karaarslan, Numan; Özbek, Hanefi; Şimşek, Abdullah Talha; Kaya, Yasin Emre; Kaplan, Necati; Akyuva, Yener; Çalışkan, Tezcan; Ateş, Özkan (Spandidos Publications, 2019)The present study aimed to evaluate the effects of dipyrone, an indispensable analgesic, anti-pyretic and anti-spasmodic used in emergency departments, on nucleus pulposus and annulus fibrosus cells in vitro. After surgical ... -
Investigation of the effects of methylphenidate, an amphetamine derivative, on intervertebral disc tissue cell cultures and matrix structures
Kaya, Yasin Emre; Karaarslan, Numan; Şirin, Duygu Yaşar; Özbek, Hanefi; Kaplan, Necati; Yılmaz, İbrahim (Turkish Neurosurgical Society, 2019)AIM: To investigate the effects of methylphenidate (MPH), on intervertebral disc tissue (IVD) cell cultures and extracellular matrix structures. Changes in the expression of some important marker genes involved in anabolic ... -
Investigation of the effects of tigecycline, a semi-synthetic derivative of minocycline, on chondrocyte cultures
Kaya, Yasin Emre; Karaarslan, Numan; Yılmaz, İbrahim; Yaşar Şirin, Duygu; Yaman, Onur; Özbek, Hanefi; Ateş, Özkan (Annals of Medical Research Publishing Inc, 2020)Abstract Aim: Although antibiotics are generally well-tolerated, they may have cytotoxic effects. The present randomized, double-blind, in vitro study aimed to investigate the effects of tigecycline on cartilage tissue ... -
Iopromide- and gadopentetic acid-derived preparates used in MR arthrography may be harmful to chondrocytes
Öznam, Kadir; Şirin, Duygu Yaşar; Yılmaz, İbrahim; Kaya, Yasin Emre; İşyar, Mehmet; Gümüştaş, Seyit Ali; Özbek, Hanefi; Akkaya, Semih; Kayhan, Arda; Mahiroğulları, Mahir (BMC, 2017)Background: Magnetic resonance arthrography, a procedure through which contrast agents containing gadolinium and/or iopromide are administered intra-articularly, has become a useful tool in musculoskeletal diagnosis. ... -
Is implant washing and wound irrigation with rifampicin effective for preventing surgical site infections in lumbar instrumentation?
Karaarslan, Numan; Yılmaz, İbrahim; Özbek, Hanefi; Öznam, Kadir; Ateş, Özkan; Erdem, İlknur (Turkish Neurosurgical Society, 2018)AIM: To determine whether the washing of implants and autogenous bone grafts with rifampicin, and the irrigation of the surgical field using diluted rifampicin, have any significant effect on the prevention of spinal implant ... -
Is it possible to treat osteosarcoma using oligonucleotides confined into controlled release drug delivery systems?
Topuk, Savaş; Akyuva, Yener; Karaaslan, Numan; Mutlu, Çağri Ata; Yılmaz, İbrahim; İşyar, Mehmet; Şirin, Duygu Yaşar; Akkaya, Semih; Özbek, Hanefi; Mahiroğulları, Mahir (Bentham Science Publishers Ltd, 2017)Purpose: The present study aimed to analyze the researches that are at the experimental phase concerning osteosarcoma treatment. The researches included drug delivery systems which allow controlled release and imbue small ... -
Pharmaco-molecular assessment of the effects of anandamide and its antagonists on hippocampal tissue in Wistar albino rats
Yılmaz, İbrahim; Karaarslan, Numan; Yaşar Şirin, Duygu; Özbek, Hanefi (Verduci Editore s.r.l, 2020)OBJECTIVE: The members of the matrix metalloproteinase (MMP) family and cannabinoids (CBs) are reportedly associated with hippocampus-dependent memory functions. However, the effects of endogenously formed CBs on hippocampal ... -
Practical performance of hippocampal tissue resection in rats in pharmacomolecular research
Yılmaz, İbrahim; Karaarslan, Numan; Özbek, Hanefi (Turkish Neurosurgical Society, 2021)AIM: To explain how to resect hippocampal tissue in rats used as live mammalian subjects for the resection of fresh cerebral tissue in laboratories.MATERIAL and METHODS: Adult male Wistar-Albino rats (n=50) were used for ... -
Pregabalin treatment for neuropathic pain may damage intervertebral disc tissue
Karaarslan, Numan; Yılmaz, İbrahim; Yaşar Şirin, Duygu; Özbek, Hanefi; Kaplan, Necati; Kaya, Yasin Emre; Akyuva, Yener; Gürbüz, Mehmet Sabri; Öznam, Kadir; Ateş, Özkan (Spandidos Publications Ltd, 2018)The aim of the present study was to determine whether pharmaceutical preparations with pregabalin (PGB) as an active ingredient, which are widely prescribed by clinicians, exert toxic effects on human primary nucleus ... -
Spinal cerrahide gelecek vaat eden moleküler gelişmeler
Karaarslan, Numan; Yaşar Şirin, Duygu; Yılmaz, İbrahim; Özbek, Hanefi (Yüzüncü Yıl Üniversitesi Tıp Fakültesi, 2018)Amaç: Bu çalışmada, dünya genelinde yapılan çalışmalar içerisinde, omurga patolojisinin giderilmesinde araştırılan, moleküler düzeyde gerçekleştirilen hücresel bazlı hedef tedavilerin, sistematik olarak incelenip, konu ... -
A study of the effects of metformin, a biguanide derivative, on annulus fibrosus and nucleus pulposus cells
Kaya, Yasin Emre; Karaarslan, Numan; Yılmaz, İbrahim; Yaşar Şirin, Duygu; Akalan, Hande; Özbek, Hanefi (Turkish Neurosurgical Society, 2020)AIM: To investigate the effects of metformin, a drug used widely for the treatment of type 2 diabetes mellitus, on human primary cell cultures prepared from uninjured segment of disc material intervertebral disk tissues.MATERIAL ... -
A study on side effects of antibiotics used in the treatment of patients with head trauma and legal responsibility of clinicians in terms of the right to health
Karaarslan, Abdulkadir; Şimşek, Abdullah Talha; Doğan, Mustafa; Potoğlu, Bilgehan; Yılmaz, İbrahim; Karaarslan, Numan (2019)Aim: Patients with head trauma are routinely, and commonly treated with prophylactic antibiotics, which may also be used for the treatment of infection that may be developed during hospital stay. The relevant antibiotic ... -
A study on the effects of direct factor Xa inhibitors and direct thrombin inhibitors on human primary chondrocyte cultures
Kaya, Yasin Emre; Akalan, Hande; Yılmaz, İbrahim; Karaarslan, Numan; Yaşar Şirin, Duygu; Özbek, Hanefi; Ateş, Özkan (Namık Kemal University, 2019)Aim:This study investigates the effects of two direct factor Xa inhibitors, apixaban and rivaroxaban, and a direct thrombin inhibitor, dabigatran, on human primary chondrocytecultures. Materials and Methods:Monolayer ... -
Systematic evaluation of desmopressin administered to patients with aneurysmal subarachnoid hemorrhage in the light of the literature
Karaarslan, Numan; Yılmaz, İbrahim; Akgün, Feride Sinem; Çalışkan, Tezcan; Özbek, Hanefi; Ateş, Özkan (Turkish Neurosurgical Society, 2020)AIM: To discuss the management of patients with the syndrome of inappropriate antidiuretic hormone secretion (SIADH) developing after subarachnoid hemorrhage, in a comparative manner in the light of the literature.MATERIAL ... -
Systematic evaluation of promising clinical trials-gene silencing for the treatment of glioblastoma
Karaarslan, Numan; Yılmaz, İbrahim; Özbek, Hanefi; Çalışkan, Tezcan; Topuk, Savaş; Yaşar Şirin, Duygu; Ateş, Özkan (Turkish Neurosurgical Society, 2019)AIM: To systematically investigate the role of artificial small interfering RNA (SiRNA) molecules in glioblastoma treatment and to give a detailed overview of the literature concerning studies performed in this field ... -
Toxicity of the acetyl-para-aminophenol group of medicines to intact intervertebral disc tissue cells
Karaarslan, Numan; Yılmaz, İbrahim; Yaşar Şirin, Duygu (Spandidos Publications Ltd., 2021)The present study aimed to investigate the effects of paracetamol, an analgesic and antipyretic that is used in emergency departments and neurosurgery departments for postoperative pain management on intervertebral disc ...