ORCID "0000-0002-9476-8488" Makale Koleksiyonu için listeleme
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Phosphorylation of PI3K/Akt at Thr308, but not phosphorylation of MAPK kinase, mediates lithium-induced neuroprotection against cerebral ischemia in mice
Ateş, Nilay; Çağlayan, Aysun; Balçıkanlı, Zeynep; Sertel, Elif; Beker, Mustafa Çağlar; Dilsiz, Pelin; Çağlayan, Ahmet Burak; Çelik, Süleyman; Daşdelen, Muhammed Furkan; Çağlayan, Berrak; Yiğitbaşı, Türkan; Özbek, Hanefi; Doeppner, Thorsten Roland; Hermann, Dirk Matthias; Kılıç, Ertuğrul (Academic Press Inc., 2022)Lithium, in addition to its effect on acute and long-term bipolar disorder, is involved in neuroprotection after ischemic stroke. Yet, its mechanism of action is still poorly understood, which was only limited to its ... -
Poloxamer P85 increases anticancer activity of schiff base against prostate cancer in vitro and in vivo
Demirci, Selami; Doğan, Ayşegül; Türkmen Bacak, Neşe; Telci, Dilek; Çağlayan, Ahmet Burak; Beker, Mustafa Çağlar; Kılıç, Ertuğrul; Özkan, Ferda; Dede, Bülent; Şahin, Fikrettin (Lippincott Williams and Wilkins, 2017)Prostate cancer is the second most common cancer among men and the leading cause of death after lung cancer. Development of hormone-refractory disease is a crucial step for prostate cancer progression for which an effective ... -
Reduced folate carrier 1 is present in retinal microvessels and crucial for the inner blood retinal barrier integrity
Gürler, Gökçe; Belder, Nevin; Beker, Mustafa Çağlar; Sever Bahçekapılı, Melike; Uruk, Gökhan; Kılıç, Ertuğrul; Yemişçi, Müge (BioMed Central Ltd, 2023)BackgroundReduced folate carrier 1 (RFC1; SLC19a1) is the main responsible transporter for the B9 family of vitamins named folates, which are essential for normal tissue growth and development. While folate deficiency ... -
The role of circadian rhythm in the regulation of cellular protein profiles in the brain
Beker, Mustafa Çağlar; Kılıç, Ertuğrul (The Scientific and Technological Research Council of Turkey, 2021)Background/aim: Circadian rhythm plays a significant role in the regulation of almost all kinds of physiological processes. In addition, it may also have a direct or indirect effect on the neurodegenerative processes, ... -
Short-term diet restriction but not alternate day fasting prevents cisplatin-induced nephrotoxicity in mice
Günebakan, Evrin; Yalçın, Esra; Çikler Dülger, Esra; Yiğitbaşı, Ahmet; Ateş, Nilay; Çağlayan, Aysun; Beker, Mustafa Çağlar; Şahin, Kâzim; Korkaya, Hasan; Kılıç, Ertuğrul (MDPI AG, 2020)Cisplatin (CP) is one of the most preferred platinum-containing antineoplastic drugs. However, even in nontoxic plasma concentrations, it may cause kidney injury. To be able to increase its effective pharmacological dose, ... -
Social isolation initiated post-weaning augments ischemic brain injury by promoting pro-inflammatory responses
Daşdelen, Muhammed Furkan; Çağlayan, Ahmet Burak; Er, Sezgin; Beker, Mustafa Çağlar; Ateş, Nilay; Gronewold, Janine; Doeppner, Thorsten Roland; Hermann, Dirk M.; Kılıç, Ertuğrul (Academic Press Inc., 2024)Social isolation is associated with poor stroke outcome, but the underlying molecular mechanisms were largely unknown. In male Balb/C mice exposed to transient middle cerebral artery occlusion (MCAo), we examined the effects ... -
Striatal dopaminergic neurons as a potential target for GDNF based ischemic stroke therapy
Beker, Mustafa Çağlar; Beker, Merve; Çağlayan, Ahmet Burak; Bolat, Busenur; Kılıç, Ülkan; Köse, Gamze; Kılıç, Ertuğrul (Turkey Clinics, 2022)Background/aim: Glial cell-line-derived neurotrophic factor (GDNF) is a well-known regulatory neurotrophic factor on dopaminergic neurons. Several pathologies have been documented so far in case of any impairment in the ... -
Targeting different pathophysiological events after traumatic brain injury in mice: Role of melatonin and memantine
Keleştemur, Taha; Yuluğ, Burak; Çağlayan, Ahmet Burak; Beker, Mustafa Çağlar; Kılıç, Ülkan; Çağlayan, Berrak; Yalçın, Esra; Gündoğdu, Reyhan Zeynep; Kılıç, Ertuğrul (Elsevier Ireland Ltd, 2016)The tissue damage that emerges during traumatic brain injury (TBI) is a consequence of a variety of pathophysiological events, including free radical generation and over-activation of N-methyl-D-aspartate-type glutamate ... -
Time dependent impact of perinatal hypoxia on growth hormone, insulin-like growth factor 1 and insulin-like growth factor binding protein-3
Kartal, Ömer; Aydınöz, Seçil; Kartal, Ayşe Tuğba; Keleştemur, Taha; Çağlayan, Ahmet Burak; Beker, Mustafa Çağlar; Karademir, Ferhan; Süleymanoğlu, Selami; Kul, Mustafa; Yuluğ, Burak; Kılıç, Ertuğrul (Springer/Plenum Publishers, 2016)Hypoxic-ischemia (HI) is a widely used animal model to mimic the preterm or perinatal sublethal hypoxia, including hypoxic-ischemic encephalopathy. It causes diffuse neurodegeneration in the brain and results in mental ... -
Time-of-day dependent neuronal injury after ischemic stroke: Implication of circadian clock transcriptional factor bmal1 and survival kinase akt
Beker, Mustafa Çağlar; Çağlayan, Berrak; Yalçın, Esra; Çağlayan, Ahmet Burak; Türkseven, Şeyma; Gürel, Büşra; Keleştemur, Taha; Sertel, Elif; Şahin, Zafer; Kutlu, Selim; Kılıç, Ülkan; Baykal, Ahmet Tarık; Kılıç, Ertuğrul (Humana Press Inc, 2018)Occurrence of stroke cases displays a time-of-day variation in human. However, the mechanism linking circadian rhythm to the internal response mechanisms against pathophysiological events after ischemic stroke remained ... -
The unconventional growth factors cerebral dopamine neurotrophic factor and mesencephalic astrocyte-derived neurotrophic factor promote post-ischemic neurological recovery, perilesional brain remodeling, and lesion-remote axonal plasticity
Çağlayan, Ahmet Burak; Beker, Mustafa Çağlar; Sertel Evren, Elif; Çağlayan, Berrak; Kılıç, Ülkan; Ateş, Nilay; Çağlayan, Aysun; Daşdelen, Muhammed Furkan; Doeppner, Thorsten Roland; Saarma, Mart; Hermann, Dirk Matthias; Kılıç, Ertuğrul (Springer, 2023)Considerable efforts are currently made to develop strategies that boost endogenous recovery once a stroke has occurred. Owing to their restorative properties, neurotrophic factors are attractive candidates that capitalize ...