ORCID "0000-0002-8084-7855" Makale Koleksiyonu için listeleme
-
Evaluation of the expression and proliferation of degenerative markers in primary cell cultures obtained from human intervertebral disc tissue
Kaya, Yasin Emre; Akalan, Hande; Yılmaz, İbrahim; Karaarslan, Numan; Yaşar Şirin, Duygu; Özbek, Hanefi (Annals of Medical Research Publishing Inc, 2020)Aim: A major cause of low back pain is disc degeneration. Nevertheless, no specific and reliable markers of the degeneration of the nucleus pulposus (NP) are available. This presented study aimed to examine changes in the ... -
Hepatoprotective effects of coriandrum sativum essential oil against acute hepatotoxicity induced by carbon tetrachloride on rats
Özbek, Hanefi; Kırmızı, Neriman İpek; Cengiz, Nureddin; Erdoğan, Ender (University of Istanbul, 2016)The aim of this study was to evaluate effect of Coriandrum sativum (CS) essential oil in rat model of carbon tetrachloride (CCl4) induced liver toxicity. Experimental groups were formed as follows: isotonic saline solution ... -
Hypoglycemic activity of capparis ovata desf. Var. palaestina zoh. methanol extract
Okur, Mehmet Evren; Özbek, Hanefi; Çiçek Polat, Derya; Yılmaz, Sezen; Arslan, Rana (Faculdade de Ciencias Farmaceuticas (Biblioteca), 2018)Caper (Capparis ovata Desf. and Capparis spinosa L.) is naturally widespread in Turkey. Traditionally, buds, fruits, seeds and roots of this plant are used as tonic, diuretic, anti-rheumatic, expectorant, antidiabetic, and ... -
In-vitro evaluation of the effects of tigecycline on annulus firosus and nucleus pulposus
Kaya, Yasin Emre; Yılmaz, İbrahim; Karaarslan, Numan; Bilir, Bülent; Yaşar Şirin, Duygu; Özbek, Hanefi (Annals of Medical Research Publishing Inc, 2020)Aim: This study aimed to examine the effects of tigecycline on primary cell cultures established using intervertebral disc tissues. Material and Methods: Primary Annulus Fibrosus and Nucleus Pulposus cultures were obtained ... -
Investigation of the anti-inflammatory, hypoglycemic activity and median lethal dose (LD50) level of limonene in mice and rats
Sever Yılmaz, Betül; Özbek, Hanefi (University of Istanbul, 2018)The aim of this study is to investigate the anti-inflammatory, hypoglycemic activity and median lethal lose (LD50) level of limonene mice and rats. Lethal dose levels were investigated using the probit analysis method. For ... -
Investigation of the effect of dipyrone on cells isolated from intervertebral disc tissue
Akgün, Feride Sinem; Şirin, Duygu Yaşar; Yılmaz, İbrahim; Karaarslan, Numan; Özbek, Hanefi; Şimşek, Abdullah Talha; Kaya, Yasin Emre; Kaplan, Necati; Akyuva, Yener; Çalışkan, Tezcan; Ateş, Özkan (Spandidos Publications, 2019)The present study aimed to evaluate the effects of dipyrone, an indispensable analgesic, anti-pyretic and anti-spasmodic used in emergency departments, on nucleus pulposus and annulus fibrosus cells in vitro. After surgical ... -
Investigation of the effects of methylphenidate, an amphetamine derivative, on intervertebral disc tissue cell cultures and matrix structures
Kaya, Yasin Emre; Karaarslan, Numan; Şirin, Duygu Yaşar; Özbek, Hanefi; Kaplan, Necati; Yılmaz, İbrahim (Turkish Neurosurgical Society, 2019)AIM: To investigate the effects of methylphenidate (MPH), on intervertebral disc tissue (IVD) cell cultures and extracellular matrix structures. Changes in the expression of some important marker genes involved in anabolic ... -
Investigation of the effects of tigecycline, a semi-synthetic derivative of minocycline, on chondrocyte cultures
Kaya, Yasin Emre; Karaarslan, Numan; Yılmaz, İbrahim; Yaşar Şirin, Duygu; Yaman, Onur; Özbek, Hanefi; Ateş, Özkan (Annals of Medical Research Publishing Inc, 2020)Abstract Aim: Although antibiotics are generally well-tolerated, they may have cytotoxic effects. The present randomized, double-blind, in vitro study aimed to investigate the effects of tigecycline on cartilage tissue ... -
Iopromide- and gadopentetic acid-derived preparates used in MR arthrography may be harmful to chondrocytes
Öznam, Kadir; Şirin, Duygu Yaşar; Yılmaz, İbrahim; Kaya, Yasin Emre; İşyar, Mehmet; Gümüştaş, Seyit Ali; Özbek, Hanefi; Akkaya, Semih; Kayhan, Arda; Mahiroğulları, Mahir (BMC, 2017)Background: Magnetic resonance arthrography, a procedure through which contrast agents containing gadolinium and/or iopromide are administered intra-articularly, has become a useful tool in musculoskeletal diagnosis. ... -
Is implant washing and wound irrigation with rifampicin effective for preventing surgical site infections in lumbar instrumentation?
Karaarslan, Numan; Yılmaz, İbrahim; Özbek, Hanefi; Öznam, Kadir; Ateş, Özkan; Erdem, İlknur (Turkish Neurosurgical Society, 2018)AIM: To determine whether the washing of implants and autogenous bone grafts with rifampicin, and the irrigation of the surgical field using diluted rifampicin, have any significant effect on the prevention of spinal implant ... -
Is it possible to treat osteosarcoma using oligonucleotides confined into controlled release drug delivery systems?
Topuk, Savaş; Akyuva, Yener; Karaaslan, Numan; Mutlu, Çağri Ata; Yılmaz, İbrahim; İşyar, Mehmet; Şirin, Duygu Yaşar; Akkaya, Semih; Özbek, Hanefi; Mahiroğulları, Mahir (Bentham Science Publishers Ltd, 2017)Purpose: The present study aimed to analyze the researches that are at the experimental phase concerning osteosarcoma treatment. The researches included drug delivery systems which allow controlled release and imbue small ... -
The levels of nitrite, nitrate and lipid peroxidation in diabetic mouse brain: The effect of melatonin and pentoxifylline
Yalçınkaya, Ahmet S.; Şekeroğlu, Mehmet Ramazan; Huyut, Zübeyir; Çokluk, Erdem; Özbek, Hanefi; Öztürk, Gürkan; Balahoroğlu, Ragıp (Taylor & Francis Ltd, 2022)Objective: This study investigated the relationship between diabetes (DM) and nitrite, nitrate and MDA levels and effect of melatonin and pentoxifylline. Methods: Sixty mice were randomly divided into four groups. Control: ... -
Majistral ilaçlar: Olgu sunumu
Özbek, Hanefi; Kırmızı, Neriman İpek (Adli Tıp Kurumu, 2016)Majistral ilaç, hasta için özel olarak hekim tarafından reçete edilen ve eczanede bu formüle göre hazırlanan ilaç olaraktanımlanmakta; majistral ilaçlarla ilgili hususlar Eczacılar ve Eczaneler Hakkında Yönetmelik hükümlerine ... -
Pharmaco-molecular assessment of the effects of anandamide and its antagonists on hippocampal tissue in Wistar albino rats
Yılmaz, İbrahim; Karaarslan, Numan; Yaşar Şirin, Duygu; Özbek, Hanefi (Verduci Editore s.r.l, 2020)OBJECTIVE: The members of the matrix metalloproteinase (MMP) family and cannabinoids (CBs) are reportedly associated with hippocampus-dependent memory functions. However, the effects of endogenously formed CBs on hippocampal ... -
A pilot study of reliability and validity of Turkish version of West Haven-Yale Multidimensional Pain Inventory in patients with low back pain
Ertunç Gülçelik, Gönül; Malkoç, Melih; Özbek, Hanefi; Yıldız Özer, Aysel (Anaesthesia, Pain & Intensive Care, 2020)Background: West Haven-Yale Multidimensional Pain Inventory (WHYMPI), used in the evaluation of patients with chronic pain including behavioral and cognitive assessment, is a multidimensional pain scale consisting of three ... -
Practical performance of hippocampal tissue resection in rats in pharmacomolecular research
Yılmaz, İbrahim; Karaarslan, Numan; Özbek, Hanefi (Turkish Neurosurgical Society, 2021)AIM: To explain how to resect hippocampal tissue in rats used as live mammalian subjects for the resection of fresh cerebral tissue in laboratories.MATERIAL and METHODS: Adult male Wistar-Albino rats (n=50) were used for ... -
Preclinical evaluation of scorzonera sp root extracts and major compounds against acute hepatotoxicity induced by carbon tetrachloride
Özbek, Hanefi; Bahadır Acıkara, Özlem; Keskin, İlknur; Kırmızı, Neriman İpek; Yiğitbaşı, Türkan; Sakul, Ayşe Arzu; İşcan, Gülçin Saltan (Wolters Kluwer Medknow Publications, 2017)Evaluation of hepatoprotective activities of Scorzonera roots and their major compounds, was aimed in current study. Scorzonera latifolia, S. tomentosa, S. mollis ssp. szowitsii, S. parviflora and S. cana var. jacquiniana ... -
Pregabalin treatment for neuropathic pain may damage intervertebral disc tissue
Karaarslan, Numan; Yılmaz, İbrahim; Yaşar Şirin, Duygu; Özbek, Hanefi; Kaplan, Necati; Kaya, Yasin Emre; Akyuva, Yener; Gürbüz, Mehmet Sabri; Öznam, Kadir; Ateş, Özkan (Spandidos Publications Ltd, 2018)The aim of the present study was to determine whether pharmaceutical preparations with pregabalin (PGB) as an active ingredient, which are widely prescribed by clinicians, exert toxic effects on human primary nucleus ... -
Prematür akut koroner sendrom hastalarında yüksek serum interlökin-17A düzeyi
Demir, Bülent; Ünğan, İsmail; Oflar, Ersan; Khankishiyev, Vüsal; Pirhan, Osman; Demir, Esra; Özbek, Hanefi; Karakaya, Osman (Turkiye Klinikleri, 2015)Amaç: Prematür akut koroner sendrom geçiren hastalarda serum interlökin (IL)-17A düzeyinin değerlendirilmesidir. Gereç ve Yöntemler: Aralık 2013-Ocak 2015 tarihleri arasında hastanemiz acil servisine başvuran ve akut koroner ... -
Psychiatric evaluation of juvenile delinquents under probation in the context of recidivism
Poyraz Fındık, Onur Tuğçe; Rodopman-Arman, Ayşe; Ertürk Altınel, Nesrin; Durlanık, Emine Güliz; Özbek, Hanefi; Semerci, Bengi (Taylor and Francis Ltd., 2019)OBJECTIVE: High rates of psychiatric disorders and comorbidities have been reported in the juvenile justice system, and both phenomena are thought to contribute to repetitive offending. Although extensive research on the ...