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Toplam kayıt 9, listelenen: 1-9
Biomechanical study on three screw-based atlantoaxial fixation techniques: A finite element study
(Korean Society of Spine Surgery, 2022)
Study Design: This is a finite element study. Purpose: This study is aimed to compare the biomechanical behaviors of three screw-based atlantoaxial fixation techniques. Overview of Literature: Screw-based constructs that ...
Investigation into cervical spine biomechanics following single, multilevel and hybrid disc replacement surgery with dynamic cervical implant and fusion: A finite element study
(Multidisciplinary Digital Publishing Institute (MDPI), 2022)
Cervical fusion has been a standard procedure for treating abnormalities associated with the cervical spine. However, the reliability of anterior cervical discectomy and fusion (ACDF) has become arguable due to its adverse ...
Temperature and pH-dependent behaviors of mAb drugs: A case study for trastuzumab
(MDPI, 2022)
The distortions in the high-order structure of therapeutic monoclonal antibodies (mAbs) under different environmental conditions acutely affect mAb stability, resulting in altered safety, efficacy, and shelf-life profiles. ...
Mechanistic insight into the impact of a bivalent ligand on the structure and dynamics of a GPCR oligomer
(Elsevier B.V., 2022)
Development of effective bivalent ligands has become the focus of intensive research toward modulation of G protein-coupled receptor (GPCR) oligomers, particularly in the field of GPCR pharmacology. Experimental studies ...
A novel fontan Y-graft for interrupted inferior vena cava and azygos continuation
(Elsevier Science, 2022)
Objectives: To evaluate the hemodynamicdynamic advantage of a new Fontan surgical template that is intended for complex single-ventricle patients with interrupted inferior vena cava-azygos and hemi-azygos continuation. The ...
Radiation type- and dose-specific transcriptional responses across healthy and diseased mammalian tissues
(MDPI, 2022)
Ionizing radiation (IR) is a genuine genotoxic agent and a major modality in cancer treatment. IR disrupts DNA sequences and exerts mutagenic and/or cytotoxic properties that not only alter critical cellular functions but ...
Selective binding of pVTK peptide-and bisphosphonate-functionalized micelles to prostate cancer cells, osteoblasts, and osteoclasts
(Andover House, Inc., 2022)
This report describes the development of functionalized polymeric micelles encapsulating a chemotherapeutic agent. The results indicate the ability to achieve selective uptake into different cell populations in metastatic ...
Antileishmanial activity of BNIPdaoct- and BNIPdanon-loaded emulsomes on leishmania infantum parasites
(Frontiers Media S.A., 2022)
Among bisnaphthalimidopropyl (BNIP) derivatives, BNIPDaoct and BNIPDanon recently came forward with antileishmanial activities beyond the standard, commercialized antileishmanial therapies. However, high-level toxicity on ...
Characterization of FcγRIa (CD64) as a ligand molecule for site-specific IgG1 capture: A side-by-side comparison with protein a
(American Chemical Society, 2022)
Fc γreceptors (FcγRs) are one of the structures that can initiate effector function for monoclonal antibodies. FcγRIa has the highest affinity toward IgG1-type monoclonal antibodies among all FcγRs. In this study, a ...