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dc.contributor.authorOkur, Neslihan Üstündağ
dc.contributor.authorHökenek, Nesrin
dc.contributor.authorOkur, Mehmet Evren
dc.contributor.authorAyla, Şule
dc.contributor.authorYoltaş, Ayşegül
dc.contributor.authorSiafaka, Panoraia I.
dc.contributor.authorCevher, Erdal
dc.date.accessioned2019-07-11T12:52:36Z
dc.date.available2019-07-11T12:52:36Z
dc.date.issued2019en_US
dc.identifier.citationOkur, N. Ü., Hökenek, N., Okur, M. E., Ayla, Ş., Yoltaş, A. ... Cevher, E. (2019). An alternative approach to wound healing field; New composite films from natural polymers for Mupirocin dermal delivery. Saudi Pharmaceutical Journal, 27(5), 738-752. https://doi.org/10.1016/j.jsps.2019.04.010en_US
dc.identifier.issn1319-0164
dc.identifier.issn2213-7475
dc.identifier.urihttps://doi.org/10.1016/j.jsps.2019.04.010
dc.identifier.urihttps://hdl.handle.net/20.500.12511/4109
dc.description.abstractIn this study, novel adhesive films were prepared for Mupirocin dermal delivery. Natural polymers as chitosan, sodium alginate and carbopol were used for films development to evaluate possible interactions and drug release properties. Solvent evaporation method was used for films preparation. Preliminary studies involved FT-IR spectroscopy and Scanning Electron Microscopy to specify interactions and morphology. Thickness, tensile strength and water uptake in phosphate buffer saline were evaluated whereas in vitro release studies were also performed. In vitro drug release studies demonstrated that mupirocin release was improved. Ex vivo bioadhesion and permeation studies using Balb-c mice were performed to check the suitability of the films. Antimicrobial ability was evaluated by agar well diffusion tests. Finally, excisional wound model applied to test the wound healing effect and evaluated macroscopic and histopathologically. One formulation was found more effective compared to the market product for wound healing at Balb-c mice.en_US
dc.language.isoengen_US
dc.publisherElsevieren_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International*
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectChitosanen_US
dc.subjectSodium Alginateen_US
dc.subjectMupirocinen_US
dc.subjectDermal Deliveryen_US
dc.subjectWound Healingen_US
dc.subjectIn Vivoen_US
dc.titleAn alternative approach to wound healing field; New composite films from natural polymers for Mupirocin dermal deliveryen_US
dc.typearticleen_US
dc.relation.journalSaudi Pharmaceutical Journalen_US
dc.departmentİstanbul Medipol Üniversitesi, Eczacılık Fakültesi, Eczacılık Teknolojisi Bölümü, Farmasötik Teknoloji Ana Bilim Dalıen_US
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Histoloji ve Embriyoloji Ana Bilim Dalıen_US
dc.authorid0000-0003-2143-5268en_US
dc.identifier.volume27en_US
dc.identifier.issue5en_US
dc.identifier.startpage738en_US
dc.identifier.endpage752en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.doi10.1016/j.jsps.2019.04.010en_US


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