Supplementation of docosahexaenoic acid (DHA) / Eicosapentaenoic acid (EPA) in a ratio of 1/1.3 during the last trimester of pregnancy results in EPA accumulation in cord blood
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info:eu-repo/semantics/embargoedAccessTarih
2017Yazar
Büyükuslu, NihalOvalı, Sema
Altuntaş, Şükriye Leyla
Batırel, Saime
Yiğit, Pakize
Garipağaoğlu, Muazzez
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Büyükuslu, N., Ovalı, S., Altuntaş, Ş. L., Batırel, S., Yiğit, P., Garipağaoğlu, M. (2017). Supplementation of docosahexaenoic acid (DHA) / Eicosapentaenoic acid (EPA) in a ratio of 1/1.3 during the last trimester of pregnancy results in EPA accumulation in cord blood. Prostaglandins Leukotrienes and Essential Fatty Acids, 125, 32-36. https://dx.doi.org/10.1016/j.plefa.2017.08.005Özet
Omega-3 fatty acids (n-3 FA), specifically DHA, are associated with fetal growth and development. We aimed to determine the levels of DHA and EPA in cord serum after n-3 FA supplementation during the last trimester of pregnancy. Among 55 women, 23 were administered daily one capsule of n-3 FA supplement, involving DHA/EPA in a ratio of 1/1.3. Twenty nine women were enrolled as control group. Blood samples were collected at 22-24 weeks of gestation and at delivery. Fatty acids were analyzed with the method of GC-MS. Cord DHA level increased and EPA level decreased in both groups between the days of 22-24 and delivery. However, decrease in cord EPA level was significant in control group (p < 0.001) but not in supplement group (p > 0.05). Supplementation of DHA/EPA in a ratio of 1/1.3 during the last trimester of pregnancy caused higher cord EPA level compared to control group indicating an accumulation in umbilical cord.
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Prostaglandins Leukotrienes and Essential Fatty AcidsCilt
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