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dc.contributor.authorShimizu, Takehiko
dc.contributor.authorHo, Bao
dc.contributor.authorDeeley, Kathleen
dc.contributor.authorBriseno-Ruiz, Jessica
dc.contributor.authorFaraco, Italo Medeiros
dc.contributor.authorSchupack, Brett Ian
dc.contributor.authorBrancher, Joäo Armando
dc.contributor.authorPecharki, Giovana Daniela
dc.contributor.authorKüchler, Erika Calvano
dc.contributor.authorTannure, Patrícia Nivoloni
dc.contributor.authorLips, Andrea
dc.contributor.authorVieira, Thays Cristinedos Santos
dc.contributor.authorPatır, Aslı
dc.contributor.authorYıldırım, Mine
dc.contributor.authorPoletta, Fernando Adrián
dc.contributor.authorMereb, Juan Carlos
dc.contributor.authorResick, Judith M.
dc.contributor.authorBrandon, Carla A.
dc.contributor.authorOrioli, Ieda M.
dc.contributor.authorCastilla, Eduardo Enrique
dc.contributor.authorMarazita, Mary Louise
dc.contributor.authorSeymen, Figen
dc.contributor.authorCosta, Marcelo Costra
dc.contributor.authorGranjeiro, José Mauro
dc.contributor.authorTrevilatto, Paula Cristina
dc.contributor.authorVieira, Alexandre Rezende
dc.identifier.citationShimizu, T., Ho, B., Deeley, K., Briseno-Ruiz, J., Faraco, I. M., Schupack, B. I. ... Vieira, A. R. (2012). Enamel formation genes influence enamel microhardness before and after cariogenic challenge. PLOS One, 7(9).
dc.descriptionWOS: 000309554700021en_US
dc.descriptionPubMed ID: 23028741en_US
dc.description.abstractThere is evidence for a genetic component in caries susceptibility, and studies in humans have suggested that variation in enamel formation genes may contribute to caries. For the present study, we used DNA samples collected from 1,831 individuals from various population data sets. Single nucleotide polymorphism markers were genotyped in selected genes (ameloblastin, amelogenin, enamelin, tuftelin, and tuftelin interacting protein 11) that influence enamel formation. Allele and genotype frequencies were compared between groups with distinct caries experience. Associations with caries experience can be detected but they are not necessarily replicated in all population groups and the most expressive results was for a marker in AMELX (p = 0.0007). To help interpret these results, we evaluated if enamel microhardness changes under simulated cariogenic challenges are associated with genetic variations in these same genes. After creating an artificial caries lesion, associations could be seen between genetic variation in TUFT1 (p = 0.006) and TUIP11 (p = 0.0006) with enamel microhardness. Our results suggest that the influence of genetic variation of enamel formation genes may influence the dynamic interactions between the enamel surface and the oral cavity.en_US
dc.description.sponsorshipNational Institutes of Health [R01-DE018914, R01-DE016148]en_US
dc.description.sponsorshipThis research is supported by National Institutes of Health grants R01-DE018914 and R01-DE016148. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.en_US
dc.publisherPublic Library Scienceen_US
dc.rightsAttribution 2.0 International*
dc.subjectCariogenic Challengeen_US
dc.subjectGenetic Componenten_US
dc.titleEnamel formation genes influence enamel microhardness before and after cariogenic challengeen_US
dc.relation.ispartofPLOS Oneen_US
dc.departmentİstanbul Medipol Üniversitesi, Diş Hekimliği Fakültesi, Çocuk Diş Hekimliği Ana Bilim Dalıen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US

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