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dc.contributor.authorKeskin, İlknur
dc.contributor.authorAytürk, Nilüfer
dc.contributor.authorSütçü, Mustafa
dc.contributor.authorKeskin, Mustafa
dc.contributor.authorMüdok, Tangül
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T20:02:36Z
dc.date.available10.07.201910:49:13
dc.date.available2019-07-10T20:02:36Z
dc.date.issued2017en_US
dc.identifier.citationKeskin, İ., Aytürk, N., Sütçü, M., Keskin, M. ve Müdok, T. (2017). The use of platelet-rich plasma for storage of surplus harvested skin grafts. Plastic Surgery, 25(1), 40-47. https://dx.doi.org/10.1177/2292550317693819en_US
dc.identifier.issn2292-5503
dc.identifier.issn2292-5511
dc.identifier.urihttps://dx.doi.org/10.1177/2292550317693819
dc.identifier.urihttps://hdl.handle.net/20.500.12511/3688
dc.descriptionWOS: 000403052800007en_US
dc.descriptionPubMed ID: 29026811en_US
dc.description.abstractBackground:There is a need for improved methods and storage media to sustain the tissue viability of autologous skin grafts.Objective:To compare histological changes in human skin grafts stored in platelet-rich plasma (PRP) with those of grafts stored in saline.Methods:Eight circular, 3-mm full-thickness skin graft samples were harvested from the abdominal skin of each of 5 patients scheduled to undergo an abdominoplasty procedure. Four of these graft samples were stored in saline, and the other 4 were stored in saline mixed with PRP prepared from the patient's own venous blood. Histological assessment of the microscopic appearance of the samples was performed on days 5, 8, 11, and 14. The integrity of the epidermal-dermal junction, number of keratinocytes with perinuclear halos, collagen organization, and number of fibroblasts per field were assessed. The cellular apoptosis rate was also measured on these same days.Results:On day 5, significant differences were observed microscopically between the PRP-and saline-stored grafts (P < .05). The grafts preserved in saline exhibited early marked cellular and nuclear swelling with pleomorphism, as well as early nuclear halo formation. The cell viability rate of the PRP group was significantly higher than that of the saline-stored group on day 8 (P < .05).Conclusion: Platelet-rich plasma and its inherent growth factors supported longer graft survival; however, its effect lasted only until day 8. Platelet-rich plasma may be beneficial if grafts need to be stored for delayed application(s).en_US
dc.description.abstractHistorique : Il faut am´eliorer les m´ethodes et les milieux de conservation pour maintenir la viabilit´e des greffons autologues de peau. Objectif : Comparer les changements histologiques des greffons de peau humaine conserv´es dans du plasma riche en plaquettes (PRP) a ` ceux des greffons conserv´es dans un solut´e physiologique. M´ethodologie : Les chercheurs ont pr´elev´e huit ´ echantillons de greffons circulaires de trois millime `tres de peau pleine ´epaisseur sur la peau de l’abdomen de chacun des cinq patients qui devaient subir une abdominoplastie. Quatre d’entre eux ont ´ et´e conserv ´ es dans un solut´e physiologique et les quatre autres, dans un solut´e physiologique m´elang´ea ` du PRP pr´epar´ea ` partir du propre sang veineux du patient. Les chercheurs ont proc´ed´ea ` l’´evaluation histologique de l’aspect microscopique des ´echantillons les cinquie `me, huitie `me,onzie `me et quatorzie `me jours apre `s le pr ´ ele `vement. Ils ont examin´e l’int ´ egrit´e de la jonction dermo´epidermique, le nombre de k´eratinocytes dot´es de halos p´erinucl´eaires, l’organisation du collage `ne et le nombre de fibroblastes par champ. Les mˆemes jours, ils ont mesur´e le taux d’apoptose cellulaire. R´esultats : Le cinquie `me jour, les chercheurs ont observ´e des diff´erences microscopiques significatives entre les greffons conserv´es dans le PRP et ceux conserv´es dans un solut´e physiologique (P<0,05). Les greffons conserv´es dans le solut´e physiologique pr´esentaient une hypertrophie cellulaire et nucl´eaire pr´ecoce marqu´ee accompagn´ee de pl´eomorphisme ainsi que la formation pr´ecoce de halos nucl´eaires. Le huitie `me jour, le taux de viabilit´e des cellules du groupe de PRP ´etait consid´erablement plus ´elev´e que celui des cellules du groupe de solut´e physiologique (P<0,05). Conclusion : Le plasma riche en plaquettes et les facteurs de croissance inh´erents favorisaient une plus longue survie, mais seulement jusqu’au huitie `me jour. Le plasma riche en plaquettes peut ˆetre b´en´efique si les greffes doivent ˆetre conserv´ees en vue d’ˆetre utilis´ees plus tard.en_US
dc.language.isoengen_US
dc.publisherSage Publications Incen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectGraft Storageen_US
dc.subjectGraft Survivalen_US
dc.subjectPlatelet-Rich Plasmaen_US
dc.subjectTissue Viabilityen_US
dc.titleThe use of platelet-rich plasma for storage of surplus harvested skin graftsen_US
dc.title.alternativeL’utilisation de plasma riche en plaquettes pour conserver des greffons de peau exc´edentairesen_US
dc.typearticleen_US
dc.relation.ispartofPlastic Surgeryen_US
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Histoloji ve Embriyoloji Ana Bilim Dalıen_US
dc.departmentİstanbul Medipol Üniversitesi, Rektörlük, Rejeneratif ve Restoratif Tıp Araştırmaları Merkezi (REMER)en_US
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Plastik, Rekonstrüktif ve Estetik Cerrahi Ana Bilim Dalıen_US
dc.authorid0000-0002-7059-1884en_US
dc.authorid0000-0001-5106-0159en_US
dc.authorid0000-0003-2066-7454en_US
dc.identifier.volume25en_US
dc.identifier.issue1en_US
dc.identifier.startpage40en_US
dc.identifier.endpage47en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.doi10.1177/2292550317693819en_US
dc.identifier.wosqualityQ4en_US


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