dc.contributor.author | Atay, İrem | |
dc.contributor.author | İlter, Ayça Zeynep | |
dc.contributor.author | Bagatur, Yeşim | |
dc.contributor.author | Telci, Dilek | |
dc.contributor.author | Gören, Ahmet | |
dc.contributor.author | Kırmızıbekmez, Hasan | |
dc.contributor.author | Yeşilada, Erdem | |
dc.date.accessioned | 10.07.201910:49:13 | |
dc.date.accessioned | 2019-07-10T20:02:34Z | |
dc.date.available | 10.07.201910:49:13 | |
dc.date.available | 2019-07-10T20:02:34Z | |
dc.date.issued | 2015 | en_US |
dc.identifier.citation | Atay, İ., İlter, A. Z., Bagatur, Y., Telci, D., Gören, A., Kırmızıbekmez, H. ve Yeşilada, E. (2015). Isolation of anti-inflammatory compounds from Sambucus ebulus leaves through in vitro activity-guided fractionation. 63rd International Congress and Annual Meeting of the Society-for-Medicinal-Plant-and-Natural-Product-Research içinde (1512-1512. ss.). Budapest, Hungary, August 23-27, 2015. https://dx.doi.org/10.1055/s-0035-1565693 | en_US |
dc.identifier.issn | 0032-0943 | |
dc.identifier.issn | 1439-0221 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12511/3682 | |
dc.identifier.uri | https://dx.doi.org/10.1055/s-0035-1565693 | |
dc.description | 63rd International Congress and Annual Meeting of the Society-for-Medicinal-Plant-and-Natural-Product-Research (GA) -- August 23-27, 2015 -- Budapest, Hungary | en_US |
dc.description | WOS: 000367558100418 | en_US |
dc.description.abstract | The in vitro anti-inflammatory effects of subextracts (n-hexane, chloroform, ethyl acetate, n-butanol, remaining water) of the methanol extract of the leaves of Sambucus ebulus L. (Adoxaceae) were investigated for their inhibitory activities on the activation of Nuclear factor kappa B (NF-κB) on lipopolysaccharide induced Raw 264.7 cells. The n-hexane, chloroform and ethyl acetate subextracts inhibited NF-κB activation at 50, 100 and 100 µg/mL concentrations, respectively. Two flavonoid mixtures [quercetin-3-O-β-D- glucopyranoside, quercetin-3-O-β-D-galactopyranoside], two flavonoids [isorhamnetin-3-O- β-D-glucopyranoside (1), isorhamnetin-3-O-rutinoside (2)] were isolated from ethyl acetate subextract. 10-O-acetylpatrinoside (3) and a new iridoid [Sambulin B (4)] was obtained from chloroform and n-hexane subextracts respectively. Structures were elucidated by NMR and MS. The compounds exerted inhibitions between 30 – 80% on NF-κB. Flavonoids were applied to cells at 25, 50, 75 and 100 µg/mL concentrations. Sambulin B was applied at 6,25, 12,5, 25 and Sambulin A applied at 12,5, 25 and 50 µg/mL concentrations. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Georg Thieme Verlag | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | Isolation | en_US |
dc.subject | Sambucus | en_US |
dc.subject | Ebulus | en_US |
dc.title | Isolation of anti-inflammatory compounds from Sambucus ebulus leaves through in vitro activity-guided fractionation | en_US |
dc.type | conferenceObject | en_US |
dc.relation.ispartof | 63rd International Congress and Annual Meeting of the Society-for-Medicinal-Plant-and-Natural-Product-Research | en_US |
dc.department | İstanbul Medipol Üniversitesi, Eczacılık Fakültesi, Eczacılık Meslek Bilimleri Bölümü, Farmakognozi Ana Bilim Dalı | en_US |
dc.identifier.volume | 81 | en_US |
dc.identifier.issue | 16 | en_US |
dc.identifier.startpage | 1512 | en_US |
dc.identifier.endpage | 1512 | en_US |
dc.relation.publicationcategory | Konferans Öğesi - Uluslararası - Kurum Öğretim Elemanı | en_US |
dc.identifier.doi | 10.1055/s-0035-1565693 | en_US |
dc.identifier.wosquality | Q1 | en_US |