dc.contributor.author | Vlaisavljevich, Eli | |
dc.contributor.author | Aydın, Ömer | |
dc.contributor.author | Lin, Kuang-Wei | |
dc.contributor.author | Durmaz Yüksel, Yasemin | |
dc.contributor.author | Fowlkes, Brian | |
dc.contributor.author | ElSayed, Mohamed | |
dc.contributor.author | Xu, Zhen | |
dc.date.accessioned | 10.07.201910:49:13 | |
dc.date.accessioned | 2019-07-10T20:02:33Z | |
dc.date.available | 10.07.201910:49:13 | |
dc.date.available | 2019-07-10T20:02:33Z | |
dc.date.issued | 2016 | en_US |
dc.identifier.citation | Vlaisavljevich, E., Aydın, Ö., Lin, K. W., Durmaz Yüksel, Y., Fowlkes, B., ElSayed, M. ... Xu, Z. (2016). The role of positive and negative pressure on cavitation nucleation in nanodroplet-mediated histotripsy. Physics In Medicine And Biology, 62(2), 663-682. | en_US |
dc.identifier.issn | 0031-9155 | |
dc.identifier.issn | 1361-6560 | |
dc.identifier.uri | https://dx.doi.org/10.1088/0031-9155/61/2/663 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12511/3677 | |
dc.description | WOS: 000369516600017 | en_US |
dc.description | PubMed ID: 26716568 | en_US |
dc.description.abstract | Nanodroplet-mediated histotripsy (NMH) is an ultrasound ablation technique combining histotripsy with acoustically sensitive perfluorocarbon (PFC) nanodroplets that can be selectively delivered to tumor cells for targeted tumor ablation. NMH takes advantage of the significantly reduced cavitation threshold of the nanodroplets, allowing for cavitation to be selectively generated only in regions containing nanodroplets. Understanding the physical mechanisms underlying the nanodroplet cavitation process is essential to the development of NMH. In this study, we hypothesize that cavitation nucleation is caused by the negative pressure (p-) exposed to the PFC, and the NMH cavitation threshold is therefore determined by the incident p- of the single-cycle pulses commonly used in NMH. This paper reports the first study that separately investigates the effects of negative and positive pressure on the NMH cavitation threshold using near half-cycle ultrasound pulses with dominant negative (negative-polarity pulses) or positive (positive-polarity pulses) pressure phases. Tissue phantoms containing perfluorohexane (PFH) nanodroplets were exposed to negative-polarity and positive-polarity pulses generated by a frequency compounding transducer recently developed in our lab, and the probability of generating cavitation was measured as a function of peak negative (p-) and peak positive (p+) pressure. The results showed close agreement in the p-cavitation threshold for PFH phantoms exposed to negative-polarity (11.4 +/- 0.1 MPa) and positive-polarity (11.7 +/- 0.2 MPa) pulses. The p+ at the cavitation threshold, in contrast, was measured to be significantly different for the negative-polarity (4.0 +/- 0.1 MPa) and positive-polarity (42.6 +/- 0.2 MPa) pulses. In the final part of this study, the experimental results were compared to the cavitation threshold predicted by classical nucleation theory (CNT), with results showing close agreement between simulations and experiments. Overall, the results support our hypothesis and provide significant insight into the physical mechanisms underlying NMH. | en_US |
dc.description.sponsorship | National Science Foundation; Turkish Republic the Ministry of National Education Fellowship Program [1416]; United States Department of Defense [W81XWH-11-PCRP-ID] | en_US |
dc.description.sponsorship | We would like to thank Sonja Capracotta, PhD (Technical Specialist, Nano Sight, School of Public Health, University of Michigan) for her help on NTA size and concentration measurements. This material is based upon work supported by a National Science Foundation Graduate Research Fellowship to Eli Vlaisavljevich. Omer Aydin acknowledges the support of the Turkish Republic the Ministry of National Education Fellowship Program (1416). This work was supported by a grant from the United States Department of Defense (W81XWH-11-PCRP-ID). Disclosure notice: Drs Zhen Xu, Brian Fowlkes, and Kuang-Wei Lin have financial interests and/or other relationship with HistoSonics Inc. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Iop Publishing Ltd | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.rights | Attribution-NonCommercial-NoDerivs 3.0 Unported | * |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/3.0/ | * |
dc.subject | Nanodroplet | en_US |
dc.subject | Histotripsy | en_US |
dc.subject | Ultrasound | en_US |
dc.subject | Nucleation | en_US |
dc.subject | Cavitation | en_US |
dc.subject | Acoustic Droplet Vaporization | en_US |
dc.title | The role of positive and negative pressure on cavitation nucleation in nanodroplet-mediated histotripsy | en_US |
dc.type | article | en_US |
dc.relation.ispartof | Physics In Medicine And Biology | en_US |
dc.department | İstanbul Medipol Üniversitesi, Mühendislik ve Doğa Bilimleri Fakültesi, Biyomedikal Mühendisliği Bölümü | en_US |
dc.authorid | 0000-0003-2776-5807 | en_US |
dc.identifier.volume | 61 | en_US |
dc.identifier.issue | 2 | en_US |
dc.identifier.startpage | 663 | en_US |
dc.identifier.endpage | 682 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.identifier.doi | 10.1088/0031-9155/61/2/663 | en_US |
dc.identifier.wosquality | Q2 | en_US |
dc.identifier.scopusquality | Q1 | en_US |