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dc.contributor.authorVlaisavljevich, Eli
dc.contributor.authorAydın, Ömer
dc.contributor.authorLin, Kuang-Wei
dc.contributor.authorDurmaz Yüksel, Yasemin
dc.contributor.authorFowlkes, Brian
dc.contributor.authorElSayed, Mohamed
dc.contributor.authorXu, Zhen
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T20:02:33Z
dc.date.available10.07.201910:49:13
dc.date.available2019-07-10T20:02:33Z
dc.date.issued2016en_US
dc.identifier.citationVlaisavljevich, E., Aydın, Ö., Lin, K. W., Durmaz Yüksel, Y., Fowlkes, B., ElSayed, M. ... Xu, Z. (2016). The role of positive and negative pressure on cavitation nucleation in nanodroplet-mediated histotripsy. Physics In Medicine And Biology, 62(2), 663-682.en_US
dc.identifier.issn0031-9155
dc.identifier.issn1361-6560
dc.identifier.urihttps://dx.doi.org/10.1088/0031-9155/61/2/663
dc.identifier.urihttps://hdl.handle.net/20.500.12511/3677
dc.descriptionWOS: 000369516600017en_US
dc.descriptionPubMed ID: 26716568en_US
dc.description.abstractNanodroplet-mediated histotripsy (NMH) is an ultrasound ablation technique combining histotripsy with acoustically sensitive perfluorocarbon (PFC) nanodroplets that can be selectively delivered to tumor cells for targeted tumor ablation. NMH takes advantage of the significantly reduced cavitation threshold of the nanodroplets, allowing for cavitation to be selectively generated only in regions containing nanodroplets. Understanding the physical mechanisms underlying the nanodroplet cavitation process is essential to the development of NMH. In this study, we hypothesize that cavitation nucleation is caused by the negative pressure (p-) exposed to the PFC, and the NMH cavitation threshold is therefore determined by the incident p- of the single-cycle pulses commonly used in NMH. This paper reports the first study that separately investigates the effects of negative and positive pressure on the NMH cavitation threshold using near half-cycle ultrasound pulses with dominant negative (negative-polarity pulses) or positive (positive-polarity pulses) pressure phases. Tissue phantoms containing perfluorohexane (PFH) nanodroplets were exposed to negative-polarity and positive-polarity pulses generated by a frequency compounding transducer recently developed in our lab, and the probability of generating cavitation was measured as a function of peak negative (p-) and peak positive (p+) pressure. The results showed close agreement in the p-cavitation threshold for PFH phantoms exposed to negative-polarity (11.4 +/- 0.1 MPa) and positive-polarity (11.7 +/- 0.2 MPa) pulses. The p+ at the cavitation threshold, in contrast, was measured to be significantly different for the negative-polarity (4.0 +/- 0.1 MPa) and positive-polarity (42.6 +/- 0.2 MPa) pulses. In the final part of this study, the experimental results were compared to the cavitation threshold predicted by classical nucleation theory (CNT), with results showing close agreement between simulations and experiments. Overall, the results support our hypothesis and provide significant insight into the physical mechanisms underlying NMH.en_US
dc.description.sponsorshipNational Science Foundation; Turkish Republic the Ministry of National Education Fellowship Program [1416]; United States Department of Defense [W81XWH-11-PCRP-ID]en_US
dc.description.sponsorshipWe would like to thank Sonja Capracotta, PhD (Technical Specialist, Nano Sight, School of Public Health, University of Michigan) for her help on NTA size and concentration measurements. This material is based upon work supported by a National Science Foundation Graduate Research Fellowship to Eli Vlaisavljevich. Omer Aydin acknowledges the support of the Turkish Republic the Ministry of National Education Fellowship Program (1416). This work was supported by a grant from the United States Department of Defense (W81XWH-11-PCRP-ID). Disclosure notice: Drs Zhen Xu, Brian Fowlkes, and Kuang-Wei Lin have financial interests and/or other relationship with HistoSonics Inc.en_US
dc.language.isoengen_US
dc.publisherIop Publishing Ltden_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 Unported*
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/3.0/*
dc.subjectNanodropleten_US
dc.subjectHistotripsyen_US
dc.subjectUltrasounden_US
dc.subjectNucleationen_US
dc.subjectCavitationen_US
dc.subjectAcoustic Droplet Vaporizationen_US
dc.titleThe role of positive and negative pressure on cavitation nucleation in nanodroplet-mediated histotripsyen_US
dc.typearticleen_US
dc.relation.ispartofPhysics In Medicine And Biologyen_US
dc.departmentİstanbul Medipol Üniversitesi, Mühendislik ve Doğa Bilimleri Fakültesi, Biyomedikal Mühendisliği Bölümüen_US
dc.authorid0000-0003-2776-5807en_US
dc.identifier.volume61en_US
dc.identifier.issue2en_US
dc.identifier.startpage663en_US
dc.identifier.endpage682en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.doi10.1088/0031-9155/61/2/663en_US
dc.identifier.wosqualityQ2en_US
dc.identifier.scopusqualityQ1en_US


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