dc.contributor.author | Babiloni, Claudio | |
dc.contributor.author | Del Percio, Claudio | |
dc.contributor.author | Lizio, Roberta | |
dc.contributor.author | Noce, Giuseppe | |
dc.contributor.author | Cordone, Susanna | |
dc.contributor.author | Lopez, Susanna | |
dc.contributor.author | Soricelli, Andrea | |
dc.contributor.author | Ferri, Raffaele | |
dc.contributor.author | Pascarelli, Maria Teresa | |
dc.contributor.author | Nobili, Flavio | |
dc.contributor.author | Arnaldi, Dario | |
dc.contributor.author | Aarsland, Dag | |
dc.contributor.author | Orzi, Francesco | |
dc.contributor.author | Buttinelli, Carla | |
dc.contributor.author | Giubilei, Franco | |
dc.contributor.author | Onofrj, Marco | |
dc.contributor.author | Stocchi, Fabrizio | |
dc.contributor.author | Stirpe, Paola | |
dc.contributor.author | Fuhr, Peter | |
dc.contributor.author | Gschwandtner, Ute | |
dc.contributor.author | Ransmayr, Gerhard | |
dc.contributor.author | Caravias, Georg | |
dc.contributor.author | Garn, Heinrich | |
dc.contributor.author | Sorpresi, Fabiola | |
dc.contributor.author | Pievani, Michela | |
dc.contributor.author | Frisoni, Giovanni B. | |
dc.contributor.author | D'Antonio, Fabrizia | |
dc.contributor.author | De Lena, Carlo | |
dc.contributor.author | Güntekin, Bahar | |
dc.contributor.author | Hanoğlu, Lütfü | |
dc.contributor.author | Başar, Erol | |
dc.contributor.author | Yener, Görsev | |
dc.contributor.author | Emek-Savaş, Derya Durusu | |
dc.contributor.author | Triggiani, Antonio Ivano | |
dc.contributor.author | Franciotti, Raffaella | |
dc.contributor.author | De Pandis, Maria Francesca | |
dc.contributor.author | Bonanni, Laura | |
dc.date.accessioned | 10.07.201910:49:13 | |
dc.date.accessioned | 2019-07-10T20:01:56Z | |
dc.date.available | 10.07.201910:49:13 | |
dc.date.available | 2019-07-10T20:01:56Z | |
dc.date.issued | 2017 | en_US |
dc.identifier.citation | Babiloni, C., Del Percio, C., Lizio, R., Noce, G., Cordone, S., Lopez, S. ... Bonanni, L. (2017). Abnormalities of cortical neural synchronization mechanisms in patients with dementia due to Alzheimer's and Lewy body diseases: An EEG study. Neurobiology of Aging, 55, 143-158. https://dx.doi.org/10.1016/j.neurobiolaging.2017.03.030 | en_US |
dc.identifier.issn | 0197-4580 | |
dc.identifier.issn | 1558-1497 | |
dc.identifier.uri | https://dx.doi.org/10.1016/j.neurobiolaging.2017.03.030 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12511/3495 | |
dc.description | WOS: 000405068100016 | en_US |
dc.description | PubMed ID: 28454845 | en_US |
dc.description.abstract | The aim of this retrospective exploratory study was that resting state eyes-closed electroencephalographic (rsEEG) rhythms might reflect brain arousal in patients with dementia due to Alzheimer's disease dementia (ADD), Parkinson's disease dementia (PDD), and dementia with Lewy body (DLB). Clinical and rsEEG data of 42 ADD, 42 PDD, 34 DLB, and 40 healthy elderly (Nold) subjects were available in an international archive. Demography, education, and Mini-Mental State Evaluation score were not different between the patient groups. Individual alpha frequency peak (IAF) determined the delta, theta, alpha 1, alpha 2, and alpha 3 frequency bands. Fixed beta 1, beta 2, and gamma bands were also considered. rsEEG cortical sources were estimated by means of the exact low-resolution brain electromagnetic source tomography and were then classified across individuals, on the basis of the receiver operating characteristic curves. Compared to Nold, IAF showed marked slowing in PDD and DLB and moderate slowing in ADD. Furthermore, all patient groups showed lower posterior alpha 2 source activities. This effect was dramatic in ADD, marked in DLB, and moderate in PDD. These groups also showed higher occipital delta source activities, but this effect was dramatic in PDD, marked in DLB, and moderate in ADD. The posterior delta and alpha sources allowed good classification accuracy (approximately 0.85-0.90) between the Nold subjects and patients, and between ADD and PDD patients. In quiet wakefulness, delta and alpha sources unveiled different spatial and frequency features of the cortical neural synchronization underpinning brain arousal in ADD, PDD, and DLB patients. Future prospective cross-validation studies should test these rsEEG markers for clinical applications and drug discovery. | en_US |
dc.description.sponsorship | project "GRIDCORE" (Italian Ministry of Health, Finalized Research program) [RF-2010-2319113] | en_US |
dc.description.sponsorship | The present study was developed based on the data of the informal European Consortium PDWAVES. The members and institutional affiliations of the Consortium are reported in the cover page of this manuscript. The activities for this study of Dr. Claudio Babiloni, Claudio Del Percio, and Roberta Lizio performed in the framework of the project "GRIDCORE" (Italian Ministry of Health, Finalized Research program, prot. RF-2010-2319113). | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Elsevier Science Inc. | en_US |
dc.rights | info:eu-repo/semantics/embargoedAccess | en_US |
dc.subject | Resting state electroencephalographic (rsEEG) rhythms | en_US |
dc.subject | Alzheimer's disease dementia (ADD) | en_US |
dc.subject | Parkinson's disease dementia (PDD) | en_US |
dc.subject | Dementia with Lewy body (DLB) | en_US |
dc.subject | Exact low-resolution brain electromagnetic source tomography (eLORETA) | en_US |
dc.title | Abnormalities of cortical neural synchronization mechanisms in patients with dementia due to Alzheimer's and Lewy body diseases: An EEG study | en_US |
dc.type | article | en_US |
dc.relation.ispartof | Neurobiology of Aging | en_US |
dc.department | İstanbul Medipol Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Biyofizik Ana Bilim Dalı | en_US |
dc.department | İstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Nöroloji Ana Bilim Dalı | en_US |
dc.authorid | 0000-0002-0860-0524 | en_US |
dc.authorid | 0000-0003-4292-5717 | en_US |
dc.identifier.volume | 55 | en_US |
dc.identifier.startpage | 143 | en_US |
dc.identifier.endpage | 158 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.identifier.doi | 10.1016/j.neurobiolaging.2017.03.030 | en_US |
dc.identifier.wosquality | Q2 | en_US |
dc.identifier.scopusquality | Q1 | en_US |