Abnormalities of cortical neural synchronization mechanisms in patients with dementia due to Alzheimer's and Lewy body diseases: An EEG study
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2017Author
Babiloni, ClaudioDel Percio, Claudio
Lizio, Roberta
Noce, Giuseppe
Cordone, Susanna
Lopez, Susanna
Soricelli, Andrea
Ferri, Raffaele
Pascarelli, Maria Teresa
Nobili, Flavio
Arnaldi, Dario
Aarsland, Dag
Orzi, Francesco
Buttinelli, Carla
Giubilei, Franco
Onofrj, Marco
Stocchi, Fabrizio
Stirpe, Paola
Fuhr, Peter
Gschwandtner, Ute
Ransmayr, Gerhard
Caravias, Georg
Garn, Heinrich
Sorpresi, Fabiola
Pievani, Michela
Frisoni, Giovanni B.
D'Antonio, Fabrizia
De Lena, Carlo
Güntekin, Bahar
Hanoğlu, Lütfü
Başar, Erol
Yener, Görsev
Emek-Savaş, Derya Durusu
Triggiani, Antonio Ivano
Franciotti, Raffaella
De Pandis, Maria Francesca
Bonanni, Laura
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Babiloni, C., Del Percio, C., Lizio, R., Noce, G., Cordone, S., Lopez, S. ... Bonanni, L. (2017). Abnormalities of cortical neural synchronization mechanisms in patients with dementia due to Alzheimer's and Lewy body diseases: An EEG study. Neurobiology of Aging, 55, 143-158. https://dx.doi.org/10.1016/j.neurobiolaging.2017.03.030Abstract
The aim of this retrospective exploratory study was that resting state eyes-closed electroencephalographic (rsEEG) rhythms might reflect brain arousal in patients with dementia due to Alzheimer's disease dementia (ADD), Parkinson's disease dementia (PDD), and dementia with Lewy body (DLB). Clinical and rsEEG data of 42 ADD, 42 PDD, 34 DLB, and 40 healthy elderly (Nold) subjects were available in an international archive. Demography, education, and Mini-Mental State Evaluation score were not different between the patient groups. Individual alpha frequency peak (IAF) determined the delta, theta, alpha 1, alpha 2, and alpha 3 frequency bands. Fixed beta 1, beta 2, and gamma bands were also considered. rsEEG cortical sources were estimated by means of the exact low-resolution brain electromagnetic source tomography and were then classified across individuals, on the basis of the receiver operating characteristic curves. Compared to Nold, IAF showed marked slowing in PDD and DLB and moderate slowing in ADD. Furthermore, all patient groups showed lower posterior alpha 2 source activities. This effect was dramatic in ADD, marked in DLB, and moderate in PDD. These groups also showed higher occipital delta source activities, but this effect was dramatic in PDD, marked in DLB, and moderate in ADD. The posterior delta and alpha sources allowed good classification accuracy (approximately 0.85-0.90) between the Nold subjects and patients, and between ADD and PDD patients. In quiet wakefulness, delta and alpha sources unveiled different spatial and frequency features of the cortical neural synchronization underpinning brain arousal in ADD, PDD, and DLB patients. Future prospective cross-validation studies should test these rsEEG markers for clinical applications and drug discovery.
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Neurobiology of AgingVolume
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https://dx.doi.org/10.1016/j.neurobiolaging.2017.03.030https://hdl.handle.net/20.500.12511/3495
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