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dc.contributor.authorÖzkan, Zehra Sema
dc.contributor.authorDeveci, Derya
dc.contributor.authorKumbak, Banu
dc.contributor.authorŞimşek, Mehmet
dc.contributor.authorİlhan, Fulya
dc.contributor.authorŞekercioğlu, Samet
dc.contributor.authorSapmaz, Ekrem
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T20:01:29Z
dc.date.available10.07.201910:49:13
dc.date.available2019-07-10T20:01:29Z
dc.date.issued2014en_US
dc.identifier.citationÖzkan, Z. S., Deveci, D., Kumbak, B., Şimşek, M., İlhan, F., Şekercioğlu, S. ... Sapmaz, E. (2014). What is the impact of Th1/Th2 ratio, SOCS3, IL17, and IL35 levels in unexplained infertility? Journal of Reproductive Immunology, 103, 53-58. https://dx.doi.org/10.1016/j.jri.2013.11.002en_US
dc.identifier.issn0165-0378
dc.identifier.urihttps://dx.doi.org/10.1016/j.jri.2013.11.002
dc.identifier.urihttps://hdl.handle.net/20.500.12511/3304
dc.descriptionWOS: 000336873600008en_US
dc.descriptionPubMed ID: 24368037en_US
dc.description.abstractImplantation necessitates complex interactions among the developing embryo, decidualizing endometrium, and developing maternal immune tolerance and/or alterations in cellular and humoral immune responses. Overstimulation of T helper 1 (Th1) or Th2 cytokines in systemic and local environments, alterations of the prevalence of IL17 and regulatory T cell (Treg) cytokines have also been suggested to contribute to the pathogenesis of implantation failure. We aimed to investigate the plasma levels of IL4, IL6, IL10, TNF alpha, IFN gamma, TGF beta, IL17, IL35, and SOCS3 in infertile and fertile women. This case-control study was conducted with 80 women suffering from unexplained infertility and 40 fertile women. Peripheral venous blood samples were drawn on day 21 of the menstrual cycle. The extracted plasma samples were assayed by an enzyme linked immunosorbent assay. Statistical analysis was performed using SPSS version 16.0. Our main findings were as follows: despite the significantly high IL17 and IL35 plasma levels of infertile women, IL35/IL17 ratio was significantly lower in the infertile group compared with that in the fertile group; SOCS3 plasma levels showed an inverse relation with plasma levels of all cytokines except IL35; increased plasma IL17 levels (>3.42 pg/mL) have a negative impact on fertility; TNF alpha/IL10, IFN gamma/IL10, IFN-gamma/16, and IFN gamma/IL4 ratios were significantly higher in infertile group compared with those in the fertile group. It is not possible to show the major immunological factor(s) of unexplained infertility, but our findings point out that the decreased suppressor activity of the immune system may play a role in implantation failure. (C) 2013 Elsevier Ireland Ltd. All rights reserved.en_US
dc.description.sponsorshipFirat University Scientific Research Foundationen_US
dc.description.sponsorshipThis study was supported by the Firat University Scientific Research Foundation. We thank Prof. Dr. Ali Risvanli for his support during this study.en_US
dc.language.isoengen_US
dc.publisherElsevieren_US
dc.rightsinfo:eu-repo/semantics/embargoedAccessen_US
dc.subjectInfertilityen_US
dc.subjectImplantationen_US
dc.subjectIL17en_US
dc.subjectIL35en_US
dc.subjectSOCS3en_US
dc.subjectT Helperen_US
dc.titleWhat is the impact of Th1/Th2 ratio, SOCS3, IL17, and IL35 levels in unexplained infertility?en_US
dc.typearticleen_US
dc.relation.journalJournal of Reproductive Immunologyen_US
dc.departmentİstanbul Medipol Üniversitesi, Uluslararası Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Kadın Hastalıkları ve Doğum Ana Bilim Dalıen_US
dc.authorid0000-0002-3428-7359en_US
dc.identifier.volume103en_US
dc.identifier.startpage53en_US
dc.identifier.endpage58en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.doi10.1016/j.jri.2013.11.002en_US


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