• Türkçe
    • English
  • English 
    • Türkçe
    • English
  • Login
View Item 
  •   [email protected]
  • Araştırma Çıktıları | TR-Dizin | WoS | Scopus | PubMed
  • Scopus İndeksli Yayınlar Koleksiyonu
  • View Item
  •   [email protected]
  • Araştırma Çıktıları | TR-Dizin | WoS | Scopus | PubMed
  • Scopus İndeksli Yayınlar Koleksiyonu
  • View Item
JavaScript is disabled for your browser. Some features of this site may not work without it.

What is the impact of Th1/Th2 ratio, SOCS3, IL17, and IL35 levels in unexplained infertility?

Thumbnail

View/Open

Tam Metin / Full Text (458.9Kb)

Access

info:eu-repo/semantics/embargoedAccess

Date

2014

Author

Özkan, Zehra Sema
Deveci, Derya
Kumbak, Banu
Şimşek, Mehmet
İlhan, Fulya
Şekercioğlu, Samet
Sapmaz, Ekrem

Metadata

Show full item record

Citation

Özkan, Z. S., Deveci, D., Kumbak, B., Şimşek, M., İlhan, F., Şekercioğlu, S. ... Sapmaz, E. (2014). What is the impact of Th1/Th2 ratio, SOCS3, IL17, and IL35 levels in unexplained infertility? Journal of Reproductive Immunology, 103, 53-58. https://dx.doi.org/10.1016/j.jri.2013.11.002

Abstract

Implantation necessitates complex interactions among the developing embryo, decidualizing endometrium, and developing maternal immune tolerance and/or alterations in cellular and humoral immune responses. Overstimulation of T helper 1 (Th1) or Th2 cytokines in systemic and local environments, alterations of the prevalence of IL17 and regulatory T cell (Treg) cytokines have also been suggested to contribute to the pathogenesis of implantation failure. We aimed to investigate the plasma levels of IL4, IL6, IL10, TNF alpha, IFN gamma, TGF beta, IL17, IL35, and SOCS3 in infertile and fertile women. This case-control study was conducted with 80 women suffering from unexplained infertility and 40 fertile women. Peripheral venous blood samples were drawn on day 21 of the menstrual cycle. The extracted plasma samples were assayed by an enzyme linked immunosorbent assay. Statistical analysis was performed using SPSS version 16.0. Our main findings were as follows: despite the significantly high IL17 and IL35 plasma levels of infertile women, IL35/IL17 ratio was significantly lower in the infertile group compared with that in the fertile group; SOCS3 plasma levels showed an inverse relation with plasma levels of all cytokines except IL35; increased plasma IL17 levels (>3.42 pg/mL) have a negative impact on fertility; TNF alpha/IL10, IFN gamma/IL10, IFN-gamma/16, and IFN gamma/IL4 ratios were significantly higher in infertile group compared with those in the fertile group. It is not possible to show the major immunological factor(s) of unexplained infertility, but our findings point out that the decreased suppressor activity of the immune system may play a role in implantation failure. (C) 2013 Elsevier Ireland Ltd. All rights reserved.

WoS Q Kategorisi

Q1

Source

Journal of Reproductive Immunology

Volume

103

URI

https://dx.doi.org/10.1016/j.jri.2013.11.002
https://hdl.handle.net/20.500.12511/3304

Collections

  • Makale Koleksiyonu [2774]
  • PubMed İndeksli Yayınlar Koleksiyonu [2958]
  • Scopus İndeksli Yayınlar Koleksiyonu [4482]
  • WoS İndeksli Yayınlar Koleksiyonu [4800]



DSpace software copyright © 2002-2015  DuraSpace
Contact Us | Send Feedback
Theme by 
@mire NV
 

 




| Guide | Contact |

[email protected]

by OpenAIRE
Advanced Search

sherpa/romeo

Browse

All of DSpaceCommunities & CollectionsBy Issue DateAuthorsInstitution AuthorORCIDTitlesSubjectsTypeLanguageDepartmentCategoryWoS Q ValuePublisherAccess TypeThis CollectionBy Issue DateAuthorsInstitution AuthorORCIDTitlesSubjectsTypeLanguageDepartmentCategoryWoS Q ValuePublisherAccess Type

My Account

LoginRegister

Statistics

View Google Analytics Statistics

DSpace software copyright © 2002-2015  DuraSpace
Contact Us | Send Feedback
Theme by 
@mire NV
 

 


|| Instruction || Guide || Library || İstanbul Medipol University || OAI-PMH ||

Kütüphane ve Dokümantasyon Daire Başkanlığı, İstabul, Turkey
If you find any errors in content, please contact: [email protected]

Creative Commons License
[email protected] by İstanbul Medipol University Institutional Repository is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 4.0 Unported License..

[email protected]:


DSpace 6.2

tarafından İdeal DSpace hizmetleri çerçevesinde özelleştirilerek kurulmuştur.