How does pregnancy affect the patients with pituitary adenomas: A study on 113 pregnancies from Turkey
Göster/ Aç
Erişim
info:eu-repo/semantics/embargoedAccessTarih
2018Yazar
Cihan Karaca, ZüleyhaYarman, Sema
Özbaş, I.
Kadıoğlu, Pınar
Aktürk, Müjde
Kılıçlı, Fatih
Dökmetaş, Hatice Sebile
Çolak, Ramis
Atmaca, Hulusi
Cantürk, Zeynep
Altuntaş, Yüksel
Çolak Özbey, Neşe
Hatipoğlu, Nihal
Tanrıverdi, Fatih
Ünlühızarcı, Kürşad
Keleştimur, Fahrettin
Üst veri
Tüm öğe kaydını gösterKünye
Cihan Karaca, Z., Yarman, S., Özbaş, I., Kadıoğlu, P., Aktürk, M., Kılıçlı, F. ... Keleştimur, F. (2018). How does pregnancy affect the patients with pituitary adenomas: A study on 113 pregnancies from Turkey. Journal of Endocrinological Investigation, 41(1), 129-141. https://dx.doi.org/10.1007/s40618-017-0709-8Özet
Objective Data regarding pregnancies in relation to pituitary tumors are limited. The effects of pregnancy on pituitary adenomas and the effects of adenoma itself (hormonal activity, mass effects and pituitary insufficiency) and/or treatment on the ongoing gestation and developing fetus were evaluated. Methods The study was a retrospective study. A questionnaire involving questions regarding medical history before index gestation, history of related pregnancy, result of index gestation and postpartum follow-up of the patients was filled by the investigator in one of the eight Referral Endocrinology Centers from Turkey. Results One hundred and thirteen (83 prolactinoma, 21 acromegaly, 8 NFPA and 1 plurihormonal pituitary adenoma) pregnancies of 87 (60 prolactinoma, 19 acromegaly, 7 NFPA and 1 plurihormonal pituitary adenoma) patients were reviewed. The clinically important pregnancy-related tumor growth of pituitary adenomas was found to be low in previously treated adenomas. Prolactinomas were more likely to increase in size during pregnancy especially if effective prior treatment was lacking. The risk of hypopituitarism is also minimal due to pituitary adenomas during pregnancy. The results of pregnancies did not differ in patients who were on medical treatment or not for prolactinomas and acromegaly during gestation. Neural tube defect and microcephaly associated with maternal cabergoline use; Down syndrome and corpus callosum agenesis associated with maternal bromocriptine use; unilateral congenital cataract, craniosynostosis and microcephaly associated with maternal acromegaly were detected for the first time. Conclusion Medical treatment can be safely done stopped in patients with prolactinoma and acromegaly when pregnancy is confirmed and reinstituted when necessary. Prospective studies may help to determine the effects of medical treatment during gestation on the mother and fetus.
WoS Q Kategorisi
Q2Scopus Q Kategorisi
Q3Kaynak
Journal of Endocrinological InvestigationCilt
41Sayı
1Koleksiyonlar
- Makale Koleksiyonu [3811]
- PubMed İndeksli Yayınlar Koleksiyonu [4281]
- Scopus İndeksli Yayınlar Koleksiyonu [6648]
- WoS İndeksli Yayınlar Koleksiyonu [6722]