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dc.contributor.authorCihan Karaca, Züleyha
dc.contributor.authorYarman, Sema
dc.contributor.authorÖzbaş, I.
dc.contributor.authorKadıoğlu, Pınar
dc.contributor.authorAktürk, Müjde
dc.contributor.authorKılıçlı, Fatih
dc.contributor.authorDökmetaş, Hatice Sebile
dc.contributor.authorÇolak, Ramis
dc.contributor.authorAtmaca, Hulusi
dc.contributor.authorCantürk, Zeynep
dc.contributor.authorAltuntaş, Yüksel
dc.contributor.authorÇolak Özbey, Neşe
dc.contributor.authorHatipoğlu, Nihal
dc.contributor.authorTanrıverdi, Fatih
dc.contributor.authorÜnlühızarcı, Kürşad
dc.contributor.authorKeleştimur, Fahrettin
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T19:58:01Z
dc.date.available10.07.201910:49:13
dc.date.available2019-07-10T19:58:01Z
dc.date.issued2018en_US
dc.identifier.citationCihan Karaca, Z., Yarman, S., Özbaş, I., Kadıoğlu, P., Aktürk, M., Kılıçlı, F. ... Keleştimur, F. (2018). How does pregnancy affect the patients with pituitary adenomas: A study on 113 pregnancies from Turkey. Journal of Endocrinological Investigation, 41(1), 129-141. https://dx.doi.org/10.1007/s40618-017-0709-8en_US
dc.identifier.issn1720-8386
dc.identifier.urihttps://dx.doi.org/10.1007/s40618-017-0709-8
dc.identifier.urihttps://hdl.handle.net/20.500.12511/3091
dc.descriptionWOS: 000419489200014en_US
dc.descriptionPubMed ID: 28634705en_US
dc.description.abstractObjective Data regarding pregnancies in relation to pituitary tumors are limited. The effects of pregnancy on pituitary adenomas and the effects of adenoma itself (hormonal activity, mass effects and pituitary insufficiency) and/or treatment on the ongoing gestation and developing fetus were evaluated. Methods The study was a retrospective study. A questionnaire involving questions regarding medical history before index gestation, history of related pregnancy, result of index gestation and postpartum follow-up of the patients was filled by the investigator in one of the eight Referral Endocrinology Centers from Turkey. Results One hundred and thirteen (83 prolactinoma, 21 acromegaly, 8 NFPA and 1 plurihormonal pituitary adenoma) pregnancies of 87 (60 prolactinoma, 19 acromegaly, 7 NFPA and 1 plurihormonal pituitary adenoma) patients were reviewed. The clinically important pregnancy-related tumor growth of pituitary adenomas was found to be low in previously treated adenomas. Prolactinomas were more likely to increase in size during pregnancy especially if effective prior treatment was lacking. The risk of hypopituitarism is also minimal due to pituitary adenomas during pregnancy. The results of pregnancies did not differ in patients who were on medical treatment or not for prolactinomas and acromegaly during gestation. Neural tube defect and microcephaly associated with maternal cabergoline use; Down syndrome and corpus callosum agenesis associated with maternal bromocriptine use; unilateral congenital cataract, craniosynostosis and microcephaly associated with maternal acromegaly were detected for the first time. Conclusion Medical treatment can be safely done stopped in patients with prolactinoma and acromegaly when pregnancy is confirmed and reinstituted when necessary. Prospective studies may help to determine the effects of medical treatment during gestation on the mother and fetus.en_US
dc.language.isoengen_US
dc.publisherSpringeren_US
dc.rightsinfo:eu-repo/semantics/embargoedAccessen_US
dc.subjectPregnancyen_US
dc.subjectPituitaryen_US
dc.subjectAcromegalyen_US
dc.subjectProlactinomaen_US
dc.subjectAdenomaen_US
dc.titleHow does pregnancy affect the patients with pituitary adenomas: A study on 113 pregnancies from Turkeyen_US
dc.typearticleen_US
dc.relation.journalJournal of Endocrinological Investigationen_US
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, İç Hastalıkları Ana Bilim Dalıen_US
dc.identifier.volume41en_US
dc.identifier.issue1en_US
dc.identifier.startpage129en_US
dc.identifier.endpage141en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.doi10.1007/s40618-017-0709-8en_US


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