dc.contributor.author | Winnier, Diedre | |
dc.contributor.author | Norton, Luke | |
dc.contributor.author | Kanat, Mustafa | |
dc.contributor.author | Arya, Ruth | |
dc.contributor.author | Fourcaudot, Marcel | |
dc.contributor.author | Hansis-Diarte, Andrea | |
dc.contributor.author | Tripathy, Devjit | |
dc.contributor.author | DeFronzo, Ralph A. | |
dc.contributor.author | Jenkinson, Christopher P. | |
dc.contributor.author | Abdul-Ghani, Muhammad | |
dc.date.accessioned | 10.07.201910:49:13 | |
dc.date.accessioned | 2019-07-10T19:57:41Z | |
dc.date.available | 10.07.201910:49:13 | |
dc.date.available | 2019-07-10T19:57:41Z | |
dc.date.issued | 2014 | en_US |
dc.identifier.citation | Winnier, D., Norton, L., Kanat, M., Arya, R., Fourcaudot, M., Hansis-Diarte, A. ... Abdul-Ghani, M. (2014). Strong association between insulin-mediated glucose uptake and the 2-hour, not the fasting plasma glucose concentration, in the normal glucose tolerance range. The Journal of Clinical Endocrinology and Metabolism, 99(9), 3444-3449. https://dx.doi.org/10.1210/jc.2013-2886 | en_US |
dc.identifier.issn | 0021-972X | |
dc.identifier.issn | 1945-7197 | |
dc.identifier.uri | https://dx.doi.org/10.1210/jc.2013-2886 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12511/3028 | |
dc.description | WOS: 000342341400086 | en_US |
dc.description | PubMed ID: 24796924 | en_US |
dc.description.abstract | Aim: The aim of this study was to examine the relationship between whole-body insulin-mediated glucose disposal and the fasting plasma glucose concentration in nondiabetic individuals. Research Design and Methods: Two hundred fifty-three nondiabetic subjects with normal glucose tolerance (NGT), impaired fasting glucose (IFG), impaired glucose tolerance, and combined glucose intolerance received a 75-g oral glucose tolerance test and euglycemic hyperinsulinemic clamp. Total glucose disposal (TGD) during the insulin clamp was compared in IFG and NGT individuals and was related to fasting and 2-hour plasma glucose concentrations in each group. Results: TGD varied considerably between NGT and IFG individuals and displayed a strong inverse relationship with the 2-hour plasma glucose (PG; r = 0.40, P < .0001) but not with the fasting PG. When IFG and NGT individuals were stratified based on their 2-hour PG concentration, the increase in 2-hour PG was associated with a progressive decrease in TGD in both groups, and the TGD was comparable among NGT and IFG individuals. Conclusion: The present results indicate the following: 1) as in NGT, insulin-stimulated TGD varies considerably in IFG individuals; 2) the large variability in TGD in IFG and NGT individuals is related to the 2-hour PG concentration; and 3) after adjustment for the 2-hour proglucagon concentration, IFG subjects have comparable TGD with NGT individuals. | en_US |
dc.description.sponsorship | National Institutes of Health [DK097554-01, DK079195, DK24092]; Veterans Affairs merit grant | en_US |
dc.description.sponsorship | This work was supported in part by National Institutes of Health Grants DK097554-01 (to M.A.-G.), DK079195 (to C.P.J.), and DK24092 (to R.A.D.) and a Veterans Affairs merit grant (to C.P.J.). | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Endocrine Society | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | Insulin-Mediated Glucose | en_US |
dc.subject | Plasma Glucose | en_US |
dc.subject | Glucose | en_US |
dc.title | Strong association between insulin-mediated glucose uptake and the 2-hour, not the fasting plasma glucose concentration, in the normal glucose tolerance range | en_US |
dc.type | article | en_US |
dc.relation.ispartof | The Journal of Clinical Endocrinology and Metabolism | en_US |
dc.department | İstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, İç Hastalıkları Ana Bilim Dalı | en_US |
dc.identifier.volume | 99 | en_US |
dc.identifier.issue | 9 | en_US |
dc.identifier.startpage | 3444 | en_US |
dc.identifier.endpage | 3449 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.identifier.doi | 10.1210/jc.2013-2886 | en_US |
dc.identifier.wosquality | Q1 | en_US |
dc.identifier.scopusquality | Q1 | en_US |