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dc.contributor.authorWinnier, Diedre
dc.contributor.authorNorton, Luke
dc.contributor.authorKanat, Mustafa
dc.contributor.authorArya, Ruth
dc.contributor.authorFourcaudot, Marcel
dc.contributor.authorHansis-Diarte, Andrea
dc.contributor.authorTripathy, Devjit
dc.contributor.authorDeFronzo, Ralph A.
dc.contributor.authorJenkinson, Christopher P.
dc.contributor.authorAbdul-Ghani, Muhammad
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T19:57:41Z
dc.date.available10.07.201910:49:13
dc.date.available2019-07-10T19:57:41Z
dc.date.issued2014en_US
dc.identifier.citationWinnier, D., Norton, L., Kanat, M., Arya, R., Fourcaudot, M., Hansis-Diarte, A. ... Abdul-Ghani, M. (2014). Strong association between insulin-mediated glucose uptake and the 2-hour, not the fasting plasma glucose concentration, in the normal glucose tolerance range. The Journal of Clinical Endocrinology and Metabolism, 99(9), 3444-3449. https://dx.doi.org/10.1210/jc.2013-2886en_US
dc.identifier.issn0021-972X
dc.identifier.issn1945-7197
dc.identifier.urihttps://dx.doi.org/10.1210/jc.2013-2886
dc.identifier.urihttps://hdl.handle.net/20.500.12511/3028
dc.descriptionWOS: 000342341400086en_US
dc.descriptionPubMed ID: 24796924en_US
dc.description.abstractAim: The aim of this study was to examine the relationship between whole-body insulin-mediated glucose disposal and the fasting plasma glucose concentration in nondiabetic individuals. Research Design and Methods: Two hundred fifty-three nondiabetic subjects with normal glucose tolerance (NGT), impaired fasting glucose (IFG), impaired glucose tolerance, and combined glucose intolerance received a 75-g oral glucose tolerance test and euglycemic hyperinsulinemic clamp. Total glucose disposal (TGD) during the insulin clamp was compared in IFG and NGT individuals and was related to fasting and 2-hour plasma glucose concentrations in each group. Results: TGD varied considerably between NGT and IFG individuals and displayed a strong inverse relationship with the 2-hour plasma glucose (PG; r = 0.40, P < .0001) but not with the fasting PG. When IFG and NGT individuals were stratified based on their 2-hour PG concentration, the increase in 2-hour PG was associated with a progressive decrease in TGD in both groups, and the TGD was comparable among NGT and IFG individuals. Conclusion: The present results indicate the following: 1) as in NGT, insulin-stimulated TGD varies considerably in IFG individuals; 2) the large variability in TGD in IFG and NGT individuals is related to the 2-hour PG concentration; and 3) after adjustment for the 2-hour proglucagon concentration, IFG subjects have comparable TGD with NGT individuals.en_US
dc.description.sponsorshipNational Institutes of Health [DK097554-01, DK079195, DK24092]; Veterans Affairs merit granten_US
dc.description.sponsorshipThis work was supported in part by National Institutes of Health Grants DK097554-01 (to M.A.-G.), DK079195 (to C.P.J.), and DK24092 (to R.A.D.) and a Veterans Affairs merit grant (to C.P.J.).en_US
dc.language.isoengen_US
dc.publisherEndocrine Societyen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectInsulin-Mediated Glucoseen_US
dc.subjectPlasma Glucoseen_US
dc.subjectGlucoseen_US
dc.titleStrong association between insulin-mediated glucose uptake and the 2-hour, not the fasting plasma glucose concentration, in the normal glucose tolerance rangeen_US
dc.typearticleen_US
dc.relation.journalThe Journal of Clinical Endocrinology and Metabolismen_US
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, İç Hastalıkları Ana Bilim Dalıen_US
dc.identifier.volume99en_US
dc.identifier.issue9en_US
dc.identifier.startpage3444en_US
dc.identifier.endpage3449en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.doi10.1210/jc.2013-2886en_US


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