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dc.contributor.authorBeceren, Ayfer
dc.contributor.authorŞehirli, Ahmet Özer
dc.contributor.authorOmurtag, Gülden Zehra
dc.contributor.authorArbak, Serap
dc.contributor.authorTuran, Pınar
dc.contributor.authorŞener, Göksel
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T19:56:35Z
dc.date.available10.07.201910:49:13
dc.date.available2019-07-10T19:56:35Z
dc.date.issued2017en_US
dc.identifier.citationBeceren, A., Şehirli, A. Ö., Omurtag, G. Z., Arbak, S., Turan, P. ve Şener G. (2017). Protective effect of N-Acetyl-L-Cysteine (NAC) on endosulfan-induced liver and kidney toxicity in rats. International Journal of Clinical and Experimental Medicine, 10(7), 10031-10039.en_US
dc.identifier.issn1940-5901
dc.identifier.urihttps://hdl.handle.net/20.500.12511/2752
dc.descriptionWOS: 000406058200024en_US
dc.description.abstractEndosulfan-induced systemic toxicity arises from oxidative stress and glutathione depletion. This study aims to investigate the possible protective effect of N-acetyl-L-cysteine (NAC) against endosulfan-induced toxicity in the liver and kidney tissue of rats. Wistar albino rats were separated into 4 groups and administered saline, NAC, endosulfan and endosulfan + NAC for 5 days. After euthanizing the animals, trunk blood was collected, followed by the removal of the kidney and liver for histological observation, the determination of glutathione, malondialdehyde levels, collagen content and myeloperoxidase activity. Lactate dehydrogenase (LDH) activity, blood urea nitrogen, creatinine, alanine aminotransferase and aspartate aminotransferase levels were measured in serum samples, while 8-OHdG, IL-1b, IL-6 and TNF-alpha were analyzed in plasma. Endosulfan provoked a significant decrease in tissue glutathione, along with a significant increase in malondialdehyde and collagen status, as well as myeloperoxidase activity. In addition, the pro-inflammatory mediators, LDH activity, and 8-OHdG, aspartate aminotransferase, creatinine, alanine aminotransferase and blood urea nitrogen levels were significantly raised in the endosulfan group. The endosulfan + NAC group showed significant decreases in MPO activity (P < 0.001 in both liver and kidney) and MDA levels (P < 0.01 in the liver, P < 0.05 in the kidney) compared with the endosulfan only group, revealing the protective effect of NAC. Furthermore, the results show that NAC treatment prevents all of the biochemical and histopathological alterations induced by endosulfan. This data indicates that NAC administration effectively prevents the deleterious effects of endosulfan toxicity and attenuates oxidative hepato-renal oxidative damage. This is possibly the result of its antioxidant effects.en_US
dc.language.isoengen_US
dc.publisherE-Century Publishing Corpen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectEndosulfanen_US
dc.subjectN-Acetyl-L-Cysteineen_US
dc.subjectLipid Peroxidationen_US
dc.subjectGlutathioneen_US
dc.subjectMyeloperoxidaseen_US
dc.titleProtective effect of N-Acetyl-L-Cysteine (NAC) on endosulfan-induced liver and kidney toxicity in ratsen_US
dc.typearticleen_US
dc.relation.ispartofInternational Journal of Clinical and Experimental Medicineen_US
dc.departmentİstanbul Medipol Üniversitesi, Eczacılık Fakültesi, Eczacılık Meslek Bilimleri Bölümü, Farmasötik Toksikoloji Ana Bilim Dalıen_US
dc.authorid0000-0002-2018-9619en_US
dc.identifier.volume10en_US
dc.identifier.issue7en_US
dc.identifier.startpage10031en_US
dc.identifier.endpage10039en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.wosqualityQ4en_US
dc.identifier.scopusqualityQ3en_US


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