Kurum Yazarı "Şahin, Zafer" Eczacılık Fakültesi İçin Listeleme
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Novel benzofurane carbonyl analogs of donepezil as acetylcholinesterase inhibitors
Şahin, Zafer; Biltekin, Sevde Nur; Yurttaş, Leyla; Berk, Barkın; Küçükkılınç, Tuba Tüylü; Demirayak, Şeref (Elsevier B.V., 2022)Donepezil is the most prescribed drug for mild to moderate Alzheimer's Disease. There is not any alternative drug with this potency yet. New scaffolds bearing benzofurans and amines are being tested for good potency on ... -
Novel benzofurane-pyrazole derivatives with anti-inflammatory, cyclooxygenase inhibitory and cytotoxicity evaluation
Şahin, Zafer; Özhan, Yağmur; Sipahi, Hande; Biltekin, Sevde Nur; Yurttaş, Leyla; Berk, Barkın; Demirayak, Şeref (Walter de Gruyter GmbH, 2022)Novel benzofurane-pyrazolone hybrids have been synthesized for evaluating their anti-inflammatory and cytotoxic properties. 4-(2-chloroacetyl)-1,5-dimethyl-2-phenyl-1,2-dihydro-3H-pyrazol-3-one were reacted with alpha-hydroxy ... -
Synthesis and antibacterial evaluation of novel benzimidazole, benzothiazole, benzofurane, and naphtofurane derivatives of aminothiazoles
Şahin, Zafer; Tok, Büşra Işıl; Akgün, Erol; Çaşkurlu, Ayşegül; Yurttaş, Leyla; Berk, Barkın; Demirayak, Şeref (Ankara Association of Pharmaceutical Sciences, 2022)The thiazole ring is the core of bioactive molecules that generate broad activity. These activities include anticonvulsant, antimicrobial, antituberculosis, antiviral, etc. In this work, starting from seconder/cyclic amines, ... -
Synthesis and in vitro antitumor activities of novel thioamide substituted piperazinyl-1,2,4-triazines
Şahin, Zafer; Biltekin, Sevde Nur; Ozansoy, Mehmet; Hemiş, Bervis; Yurttaş, Leyla; Berk, Barkın; Demirayak, Şeref (Wiley, 2022)Triazines are in great interest for their potential to mimic nucleoside analog compounds. Three different isomers exist including 1,2,3-triazine, 1,3,5-triazine (s-triazine) and 1,2,4-triazine. All of these skeletons were ...