Başlık için Eczacılık Fakültesi listeleme
Toplam kayıt 339, listelenen: 317-336
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Synthesis of some N-[4-(benzothiazole-2yl)phenyl]-2-aryloxyacetamide derivatives and their anticancer activities
(Informa Healtcare, 2012)In this study, some N-[4-(Benzothiazole-2-yl)phenyl]-2-aryloxyacetamide derivatives were prepared by reacting N-[4-(benzothiazole-2yl)phenyl]-2-chloroacetamide and different substituent phenol or thiophenol derivatives. ... -
Synthesis, antimicrobial activity and modeling studies of thiazoles bearing pyridyl and triazolyl scaffolds
(Walter de Gruyter GmbH, 2022)In this study, novel 4-(5-((2/3/4-substituted benzyl)thio)-4-(4-substituted phenyl)-4H-1,2,4-triazol-3-yl)-2-(pyridin-3/4-yl)thiazoles were synthesized following a multi-step synthetic procedure. All the compounds were ... -
Synthesis, antimicrobial activity studies and molecular property predictions of schiff bases derived from ortho-vanillin
(University of Istanbul, 2017)Schiff bases are known to possess anticancer, antibacterial, antifungal, antitubercular, anti-inflammatory, antibacterial and antimalarial properties. At the same time, in recent years, prediction of drug-likeness, molecular, ... -
The synthesis, antimicrobial activity studies, and molecular property predictions of novel benzothiazole-2-thione derivatives
(University of Istanbul, 2017)Benzothiazoles and 2-mercaptobenzothiazoles are important classes of bioactive organic scaffolds possessing antibacterial, antifungal, antitubercular, antiinflamma-tory, antidiabetic, and antimalarial properties. In recent ... -
Synthesis, antimicrobial and anticancer activities of some naphthylthiazolylamine derivatives
(Scientific Publishers of India, 2017)New 4-naphthyl-2-aminothiazole derivatives were synthesized. The newly synthesized compounds were screened for their in vitro antimicrobial and anticancer activities. The results indicated that compound 5b namely ... -
Synthesis, antimicrobial and antioxidant activities of pyridyl substituted thiazolyl triazole derivatives
(Universidade de São Paulo, 2022)In this present study, 63 different 5-[4-methyl-2-(pyridin-3/4-yl)thiazole-5-yl]-4-substituted-3-substituted benzylthio-4H-1,2,4-triazole derivatives were synthesized, and evaluated for their in vitro antimicrobial activity ... -
Synthesis, antioxidant and antimicrobial properties of novel pyridyl-carbonyl thiazoles as dendrodoine analogs
(Scientific and Technical Research Council of Turkey, 2020)Marine compound dendrodoine was first obtained from tunicate species (Dendrodo grossularia). It has a five-membered ring, namely, it is a heterocycle thiadiazole, which is found rarely in natural sources. Following its ... -
Synthesis, characterization and antibacterial evaluation of new pyridyl-thiazole hybrids of sulfonamides
(Istanbul University, 2021)Background and Aims: Sulfonamide drugs are a very old and noted group of small molecules, and are still one of the most important antimicrobial compounds. In this study, starting from sulfonamide drugs, new original compounds ... -
Synthesis, characterization, COX1/2 inhibition and molecular modeling studies on novel 2-thio-diarylimidazoles
(Scientific Technical Research Council Turkey-Tubitak, 2021)Heterocyclic compounds with diaryl substituents have been a milestone approach for selective cyclooxygenase 2 (COX 2) inhibition by bioisosteric replacements and modifications. It is also known that thiazole derivatives ... -
Synthesis, structure elucidation and cytotoxic activities of 2,5-disubstituted-1,3,4-thiadiazole and l,2,4-triazole-3-thione derivatives
(Marmara University, 2022)In this study, a series of 1,3,4-thiadiazole (1b-9b) and l,2,4-triazole-3-thione (1c-9c) derivatives were synthesized. The reaction proses was carried out with the cyclocondensation of suitable 1,4-disubstituted thiosemicarbazide ... -
Synthesis, structure elucidation and determination of acid dissociation constant, tautomerism of pyrido [1,2-a] benzimidazole-2,4-dione
(University of Istanbul, 2016)The first starting material, 1H-2-acetylbenzimidazole, 4, was synthesized by o-phenylenediamine, 1, and lactic acid solution, 2, in hydrochloric acid medium on the first step than, oxidation reaction was performed by CrO3 ... -
Thiazole-substituted benzoylpiperazine derivatives as acetylcholinesterase inhibitors
(Wiley, 2018)Hit, Lead & Candidate Discovery After acetylcholine is released into the synaptic cleft, it is reabsorbed or deactivated by acetylcholinesterase (AChE). Studies on Alzheimer's disease (AD) in the mid-20th century proved ... -
Tilia tomentosa moench çiçeklerinin uçucu bileşenlerinin ve çeşitli in vitro biyolojik aktivitelerinin incelenmesi
(2019)Amaç: Tilia tomentosa Moench. (Malvaceae) bitkisinin çiçeklerinden elde edilen n-hekzan ekstresinin uçucu bileşenleri, toplam fenolik madde miktarı, in vitro antioksidan, antimikrobiyal ve hücre canlılığı aktivitelerinin ... -
Traditional herbal drugs against liver diseases – Experimented in vitro using HepG2 cells for induced steatosis
(Marmara University, 2023)Salvia fruticosa leaves, Malva sylvestris flowers, Taraxacum officinale aerial parts, Plantago ovata seeds, Tanacetum parthenium aerial parts, and Allium sativum bulbs are documented for traditional use against hepatic ... -
Traditional usages of some medicinal plants for pediatric diseases
(University of Ankara, 2023)Objective: Different types of pediatric diseases negatively affect the lives of many people, physically. Here, we aimed to document some medicinal plants used as traditional folk medicine in pediatrics treatment. Result ... -
Türk popülasyonunda XRCC1 (Arg399Gln) ve XRCC3 (Thr241Met) polimorfizmlerinin genotip dağılımı ve Allel frekanslarının belirlenmesi
(Galenos Yayınevi, 2021)Amaç: XRCC1 geni, serbest oksijen radikallerinin, iyonize radyasyonun, ultraviyole ve alkilleyici mutajenlerin yaptığı baz değişimi sonucu oluşan baz kesip çıkarma (eksizyon) onarımı ve DNA tek zincir kırılmalarının ... -
Two different approaches for oral administration of voriconazole loaded formulations: Electrospun fibers versus beta-cyclodextrin complexes
(MDPI, 2016)In this work, a comparison between two different preparation methods for the improvement of dissolution rate of an antifungal agent is presented. Poly(epsilon-caprolactone) (PCL) electrospun fibers and beta-cyclodextrin ...
