Başlık için Eczacılık Fakültesi listeleme
Toplam kayıt 339, listelenen: 218-237
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Nitric oxide mediated effects of nebivolol on erectile function in rats with heart failure
(IMR Press, 2022)Background and objective: Heart failure (HT) is a common complication of cardiovascular disease, which leads to functional cardiac abnormalities. Beta-blockers are commonly used to reduce mortality in HF patients; however, ... -
Non-covalent functionalization of single walled carbon nanotubes with pyrene pendant polyester: A DFT supported study
(Elsevier, 2020)Non-covalent attachment onto single-walled carbon nanotubes (SWCNTs) by protecting nanotubes' intrinsic properties has an important role in development of hybrid composite materials. Herein, we present non-covalent ... -
A novel approach for skin infections: Controlled release topical mats of poly (lactic acid)/poly(ethylene succinate) blends containing Voriconazole
(Elsevier Science Bv, 2018)The oral and injectable formulations of Voriconazole (VRZ), a known antifungal agent with low solubility, seem to cause severe side effects. Consequently, topical application of VRZ could be advantageous for skin fungal ... -
A novel approach in the treatment of osteoarthritis: In vitro and in vivo evaluation of Allium sativum microemulsion
(Wiley, 2022)Osteoarthritis (OA) is the most prevalent kind of joint disease, affecting millions of individuals worldwide. Allium sativum L. was used as a therapeutic agent in the microemulsion system against osteoarthritis due to ... -
Novel benzimidazole derivatives: Cytotoxic and apoptotic properties on lung cancer cell line
(Bentham Science Publishers, 2020)Background: Benzimidazole derivatives are privileged molecules known to have a wide variety of biological activities. In medicinal chemistry, due to the ring's structural similarity to nucleotides, its derivatives were ... -
Novel benzofurane carbonyl analogs of donepezil as acetylcholinesterase inhibitors
(Elsevier B.V., 2022)Donepezil is the most prescribed drug for mild to moderate Alzheimer's Disease. There is not any alternative drug with this potency yet. New scaffolds bearing benzofurans and amines are being tested for good potency on ... -
Novel benzofurane-pyrazole derivatives with anti-inflammatory, cyclooxygenase inhibitory and cytotoxicity evaluation
(Walter de Gruyter GmbH, 2022)Novel benzofurane-pyrazolone hybrids have been synthesized for evaluating their anti-inflammatory and cytotoxic properties. 4-(2-chloroacetyl)-1,5-dimethyl-2-phenyl-1,2-dihydro-3H-pyrazol-3-one were reacted with alpha-hydroxy ... -
Novel benzothiazole based imidazole derivatives as new cytotoxic agents against glioma (C6) and liver (HepG2) cancer cell lines
(University of Istanbul, 2017)In this work, some novel N-(6-substituted-benzothiazol-2-yl)-2-[[4,5-dimethyl-1-((p-tolyl/4-nitrophenyl)amino)-1H-imidazol-2-yl]thio]acetamide derivatives were synthesized and searched for their cytotoxic activities against ... -
Novel benzydamine hydrochloride and chlorhexidine gluconate loaded bioadhesive films for local treatment of buccal infections
(Editions de Sante, 2023)Benzydamine hydrochloride (BZD), chlorhexidine gluconate (CHG) or their combination are frequently used as liquid dosage forms for the local treatment of buccal fungal and bacterial infections. However, the short residence ... -
Novel cyanothiouracil and cyanothiocytosine derivatives as concentration-dependent selective inhibitors of U87MG glioblastomas: Adenosine receptor binding and potent PDE4 inhibition
(Elsevier France-Editions Scientifiques Medicales Elsevier, 2021)Thiouracil and thiocytosine are important heterocyclic pharmacophores having pharmacological diversity. Antitumor and antiviral activity is commonly associated with thiouracil and thiocytosine derivatives, which are well ... -
Novel hybridized computational paradigms integrated with five stand-alone algorithms for clinical prediction of HCV status among patients: A data-driven technique
(MDPI, 2023)The emergence of health informatics opens new opportunities and doors for different disease diagnoses. The current work proposed the implementation of five different stand-alone techniques coupled with four different novel ... -
Novel microemulsion containing benzocaine and fusidic acid simultaneously: Formulation, characterization, and in vitro evaluation for wound healing
(Springer Science and Business Media Deutschland GmbH, 2024)Modern drug carrier technologies, such as microemulsions with small droplet sizes and high surface areas, improve the ability of low water solubility active ingredients to permeate and localize. The goal of this study was ... -
Novel nanostructured lipid carrier based flurbiprofen loaded sodium alginate inserts for ocular drug delivery
(Colegio de Farmaceuticos de la Provincia de Buenos Aires, 2016)The aim of the present study was to develop a novel Flurbiprofen (FLB) loaded nanostructured lipid carrier (NLC) based alginate inserts for treatment of ocular inflammation. 0.3% FLB loaded NLCs were prepared by means of ... -
Novel sprayable thermosensitive benzydamine hydrogels for topical application: Development, characterization, and in vitro biological activities
(Springer Science and Business Media Deutschland GmbH, 2023)Benzydamine hydrochloride (BZD) having analgesic, anesthetic, and anti-inflammatory effects is used orally or topically in the treatment of disorders such as joint inflammation and muscle pain. Within the scope of this ... -
Novel thiazole-piperazine derivatives as potential cholinesterase inhibitors
(Wiley, 2019)Dementia is a cognitive disorder mostly associated with Alzheimer's disease (AD) in addition to being seen in many other diseases of the central nervous system (CNS). The limited number of drugs is not sufficient to provide ... -
Obturator neuropathy combined with Guillain-Barre syndrome
(Istanbul Medipol University, 2020)Obturator neuropathy caused by entrapment of obturator nerve is a disease with numbness, pain and weakness in legs. Guillain-Barre syndrome is an immune-me-diated peripheral polyneuropathy characterized by nearly same ... -
Occurrence of fumonisins B1 and B2 in homemade medicinal plants: Exposure assessment in Northern Turkey
(Akademiai Kiado Rt., 2016)This study was conducted to determine the recent level of contamination with Fumonisin B1 (FB1) and Fumonisin B2 (FB2) in major medicinal plants and to assess consumer exposure in northern Turkey. FB1 and FB2 were investigated ... -
Online-HPLC strategies, antioxidant and enzyme inhibitory activities of different extracts of mondia whitei leaves
(Biolife Sas, 2023)Background: Mondia whitei, an indigenous African plant, is widely recognised for its medicinal properties. Throughout ancient times, African communities have employed this remedy to address a wide range of health conditions. ... -
Ophthalmic applications of SLN and NLC
(Bentham Science Publishers Ltd., 2017)Background: The eyes are among the most readily accessible organs in terms of location in the body, yet drug delivery to eye tissues is particularly problematic. The anatomy, physiology and biochemistry of the eye limit ...
