Başlık için Uluslararası Tıp Fakültesi listeleme
Toplam kayıt 527, listelenen: 371-390
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A novel insight into differential expression profiles of sporadic cerebral cavernous malformation patients with different symptoms
(Nature Research, 2021)Cerebral cavernous malformation (CCM) is a vascular lesion of the central nervous system that may lead to distinct symptoms among patients including cerebral hemorrhages, epileptic seizures, focal neurologic deficits, ... -
Novel synthetic approaches for bisnaphthalimidopropyl (BNIP) derivatives as potential anti-parasitic agents for the treatment of leishmaniasis
(MDPI, 2019)Leishmaniasis is a neglected parasitic disease that is widely seen in more than 60 countries worldwide, including Turkey and its subcontinental region. There are several chemotherapy agents for the treatment of leishmaniasis, ... -
A novel theanine complex, Mg-L-Theanine improves sleep quality via regulating brain electrochemical activity
(Frontiers Media S.A., 2022)L-Theanine is commonly used to improve sleep quality through inhibitory neurotransmitters. On the other hand, Mg2+, a natural NMDA antagonist and GABA agonist, has a critical role in sleep regulation. Using the caffeine-induced ... -
Novel β‑hydroxy ketones: Synthesis, spectroscopic characterization, molecular docking, and anticancer activity studies
(Elsevier B. V., 2022)In this study, a series of novel β‑hydroxy ketone derivatives 3a-o were designed, synthesized, and evaluated for their anticancer activity. The structure of these compounds were characterized by IR, 1H and 13C NMR, mass ... -
Numerical simulation modeling of the irreversible electroporation treatment zone for focal therapy of prostate cancer, correlation with whole-mount pathology and T2-weighted MRI sequences
(Sage Publications LTD, 2019)Background: At present, it is not possible to predict the ablation zone volume following irreversible electroporation (IRE) for prostate cancer (PCa). This study aimed to determine the necessary electrical field threshold ... -
Optogenetic manipulation of neuronal circuits regulating feeding behavior
(Wiley-Blackwell, 2015)... -
Osteoprotegerin genetic polymorphisms and their influence on therapeutic response to ibandronate in postmenopausal osteoporotic females
(Public Library of Science, 2023)ObjectivesThe present study investigated osteoprotegerin (OPG) genetic polymorphisms and their influence on the therapeutic response to ibandronate in postmenopausal osteoporotic females.MethodsThis case-control study ... -
Outcomes and complications from a randomized controlled study comparing conventional stent placement versus no stent placement after ureteroscopy for distal ureteric calculus < 1 cm
(MDPI, 2022)Ureteric stent insertion following ureteroscopic lithotripsy (URSL) is a common and widely accepted procedure. However, there is no agreement on whether a ureteric stent should be placed following an uncomplicated URSL. ... -
Over kanseri̇ne yöneli̇k fotodi̇nami̇k terapi̇ temelli̇ kombi̇nasyon terapi̇ uygulaması
(Zeynep Kamil Kadın ve Çocuk Hastalıkları Eğitim ve Araştırma Hastanesi, 2018)Kanser, tüm dünyada olduğu gibi ülkemizde de en ölümcül hastalıkların başında gelmektedir. Kanserin, lokal, minimum yan etkiyle ve hedefe yönelik olarak tedavisi hasta için büyük önem taşımaktadır. Fotodinamik Terapi (FDT), ... -
Overview of current pharmacotherapeutic options in benign prostatic hyperplasia
(Taylor and Francis Ltd., 2023)Introduction: Benign prostatic hyperplasia (BPH) represents the histological entity of prostate cell proliferation, which inflicts a gradually increasing obstruction of the bladder outlet and is accompanied by a progressing ... -
Oxidative stress markers are increased in non-alcoholic fatty liver disease patients with high serum alanine aminotransferase levels
(Termedia Publishing House Ltd, 2019)Introduction: Non- alcoholic fatty liver disease (NAFLD) is a pathological disease that causes chronic damage in the liver without alcohol consumption. Aim of the research: To determine oxidative stress and inflammation ... -
Pancreatic tumor detection by convolutional neural networks
(Institute of Electrical and Electronics Engineers Inc., 2022)Artificial Intelligence and its sub-branches like Machine Learning (ML) and Deep Learning (DL) applications have the potential to have positive effects that can directly affect human life. Medical imaging provides a way ... -
Parvovirus and autoimmune diseases
(Academic Press, 2024)For decades, the role of viruses in the initiation and exacerbation of autoimmune disorders have been widely documented. Recently, a growing number of studies have been questioning the relationship between human parvovirus ... -
Patient-reported outcome measures using modified urethral stricture surgery: Patient-reported outcome measure for direct visual internal urethrotomy and nontransecting urethroplasty for short nontraumatic bulbar urethral stricture - A prospective comparative observational study from a university teaching hospital
(Wolters Kluwer Medknow Publications, 2023)Purpose: To evaluate the patient-reported outcomes of primary direct visual internal urethrotomy (DVIU) and nontransecting bulbar urethroplasty techniques (NTBU) for the short segment (<2 cm) nontraumatic bulbar urethral ... -
Patient-specific induced pluripotent stem cells for cardiac disease modeling
(Walter de Gruyter GMBH, 2019)Reprogramming of human somatic cells to induced pluripotent stem cells (iPSCs) via induction of pluripotency genes is one of the most influential scientific breakthroughs during the last decade. Behind this breakthrough ... -
The phosphatidylinositol-3 kinase/Akt pathway mediates melatonin's neuroprotective activity after focal cerebral ischemia
(Springer Heidelberg, 2014)… -
Phosphodiesterase 10A deactivation induces long-term neurological recovery, peri-infarct remodeling and pyramidal tract plasticity after transient focal cerebral ischemia in mice
(Academic Press Inc., 2022)The phosphodiesterase (PDE) superfamily comprises enzymes responsible for the cAMP and cGMP degradation to AMP and GMP. PDEs are abundant in the brain, where they are involved in several neuronal functions. High PDE10A ... -
Phosphodiesterase 10A is a critical target for neuroprotection in a mouse model of ischemic stroke
(Springer, 2022)Phosphodiesterase 10A (PDE10A) hydrolyzes adenosine 3 ',5 '-cyclic monophosphate (cAMP) and guanosine 3 ',5 '-cyclic monophosphate (cGMP). It is highly expressed in the striatum. Recent evidence implied that PDE10A may be ... -
Phosphorylation of PI3K/Akt at Thr308, but not phosphorylation of MAPK kinase, mediates lithium-induced neuroprotection against cerebral ischemia in mice
(Academic Press Inc., 2022)Lithium, in addition to its effect on acute and long-term bipolar disorder, is involved in neuroprotection after ischemic stroke. Yet, its mechanism of action is still poorly understood, which was only limited to its ...
