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A proteomic analysis of p53-independent induction of apoptosis by bortezomib in 4T1 breast cancer cell line
(Elsevier Science, 2015)
The 26S proteasome is a proteolytic enzyme found in both cytoplasm and nucleus. In this study, we examined the differential expression of proteasome inhibitor bortezomib-induced proteins in p53-deficient 4T1 cells. It was ...
Differential effects of p38 MAP kinase inhibitors SB203580 and SB202190 on growth and migration of human MDA-MB-231 cancer cell line
(Springer, 2017)
p38 mitogen-activated protein kinase (MAPK) belongs to the MAPK superfamily, phosphorylating serine and/or threonine residues of the target proteins. The activation of p38 MAPK leads to cell growth, differentiation, ...
Effect of bortezomib in combination with cisplatin and 5-fluorouracil on 4T1 breast cancer cells
(Spandidos Publications, 2013)
Bortezomib is a highly selective and reversible inhibitor of the 26S proteasome. It has been approved for the treatment of patients with relapsed and refractory multiple myeloma. A number of studies have been conducted to ...