Tıp Fakültesi by Institution Author "Akyel, Yasemin Kübra"
Now showing items 1-3 of 3
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Circadian dysfunction in adipose tissue: Chronotherapy in metabolic diseases
Civelek, Erkan; Öztürk Civelek, Dilek; Akyel, Yasemin Kübra; Kaleli Durman, Deniz; Okyar, Alper (MDPI, 2023)Essential for survival and reproduction, the circadian timing system (CTS) regulates adaptation to cyclical changes such as the light/dark cycle, temperature change, and food availability. The regulation of energy homeostasis ... -
Diurnal changes in capecitabine clock-controlled metabolism enzymes are responsible for its pharmacokinetics in male mice
Akyel, Yasemin Kübra; Öztürk Civelek, Dilek; Öztürk Seyhan, Narin; Gül, Şeref; Gazioğlu, Işıl; Pala Kara, Zeliha; Levi, Francis; Kavaklı, İbrahim Halil; Okyar, Alper (SAGE Publications Inc., 2023)The circadian timing system controls absorption, distribution, metabolism, and elimination processes of drug pharmacokinetics over a 24-h period. Exposure of target tissues to the active form of the drug and cytotoxicity ... -
TW68, cryptochromes stabilizer, regulates fasting blood glucose levels in diabetic ob/ob and high fat-diet-induced obese mice
Sürme, Saliha; Ergün, Çağla; Gül, Şeref; Akyel, Yasemin Kübra; Gül, Zeynep Melis; Özcan, Onur; Şavluğ İpek, Özgecan; Akarlar, Büşra Aytül; Özlü, Nurhan; Taşkın, Ali Cihan; Türkay, Metin; Gören, Ahmet Ceyhan; Barış, İbrahim; Öztürk, Nuri; Güzel, Mustafa; Aydın, Cihan; Okyar, Alper; Kavaklı, İbrahim Halil (Elsevier Inc., 2023)Cryptochromes (CRYs), transcriptional repressors of the circadian clock in mammals, inhibit cAMP production when glucagon activates G-protein coupled receptors. Therefore, molecules that modulate CRYs have the potential ...