Important roles of interleukin-36, interleukin-37, and interleukin-38 cytokines in the pathogenesis of rosacea
Künye
Ekinci, A., Oğuz Kılıç, S., Demir, N. ve Sıddıkoğlu, D. (2024). Important roles of interleukin-36, interleukin-37, and interleukin-38 cytokines in the pathogenesis of rosacea. Indian Journal of Dermatology, 69(3), 232-237. http://dx.doi.org/10.4103/ijd.ijd_470_23Özet
Background: Rosacea is a chronic inflammatory skin disease. Previous studies have determined that IL-36, IL-37, and IL-38 may play a role in the pathogenesis of various inflammatory diseases. Aims and Objectives: The present study aims to evaluate the relationship of these cytokines with rosacea. Materials and Methods: A total of 100 individuals, including 50 patients with rosacea and 50 healthy controls, were included in the study. IL-36, IL-37, and IL-38 levels were measured using the ELISA method by taking serum samples from all participants. Results: The mean serum levels of IL-36, IL-37, and IL-38 in the patient group were 52.17 ± 24.07 pg/ml, 18.46 ± 8.18 pg/ml, and 25.74 ± 8.36 ng/l, respectively. The mean serum levels of IL-36, IL-37, and IL-38 in the control group were 32.99 ± 19.90 pg/ml, 44.61 ± 22.27 pg/ml, and 45.61 ± 17.32 ng/l, respectively. The difference between the serum levels of IL-36, IL-37, and IL-38 in the patient and control groups was statistically significant (P < 0.001). Conclusion: Based on these findings, an increase in IL-36 and a decrease in IL-37 and IL-38 may contribute to the pathogenesis of rosacea. Future rosacea treatments could target and/or interact with these possible steps in the pathogenesis of rosacea.
Scopus Q Kategorisi
Q3Kaynak
Indian Journal of DermatologyCilt
69Sayı
3Koleksiyonlar
- Makale Koleksiyonu [3777]
- Scopus İndeksli Yayınlar Koleksiyonu [6574]
İlgili Öğeler
Başlık, yazar, küratör ve konuya göre gösterilen ilgili öğeler.
-
Relapsing remitting multipl skleroz (RRMS) hastalarında kefir gıda takviyesinin serum sitokin seviyelerine etkisinin incelenmesi
Süzen, Ahmet (İstanbul Medipol Üniversitesi Sağlık Bilimleri Enstitüsü, 2018)Multipl Skleroz (MS); enflamasyon, demiyelinizasyon ve akson hasarı ile karakterize otoimmün bir santral sinir sistemi hastalığıdır. Normalde proenflamatuar (Th1/Th17) ve antienflamatuar (Th2) sitokinler arasında ince bir ... -
Cinnamon polyphenol extract exerts neuroprotective activity in traumatic brain injury in male mice
Yuluğ, Burak; Kılıç, Ertuğrul; Altunay, Serdar; Ersavaş, Cenk; Orhan, Cemal; Dalay, Arman; Tuzcu, Mehmet; Şahin, Nurhan; Juturu, Vijaya; Şahin, Kazım (Bentham Science Publishers Ltd, 2018)Introduction: Cinnamon polyphenol extract is a traditional spice commonly used in different areas of the world for the treatment of different disease conditions which are associated with inflammation and oxidative stress. ... -
Is interleukin 17F (7488 A/G) responsible for the pathogenesis of breast and gastrointestinal cancers in Turkish patients
Özdilli, Kürşat; Günaldı, Meral; Pehlivan, Mustafa; Nursal, Ayşe Feyda; Işıksaçan, Nilgün; Pehlivan, Sacide (American Society for Cell Biology, 2018)...