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dc.contributor.authorAydın, Sabin Göktaş
dc.contributor.authorÖlmez, Ömer Fatih
dc.contributor.authorSelvi, Oğuzhan
dc.contributor.authorGeredeli, Çağlayan
dc.contributor.authorÖzden, Ferhat
dc.contributor.authorBilici, Ahmet
dc.contributor.authorAçıkgöz, Özgür
dc.contributor.authorKarcı, Ebru
dc.contributor.authorKutlu, Yasin
dc.contributor.authorHamdard, Jamshid
dc.contributor.authorAydın, Ahmet
dc.date.accessioned2024-06-04T11:55:51Z
dc.date.available2024-06-04T11:55:51Z
dc.date.issued2024en_US
dc.identifier.citationAydın, S. G., Ölmez, Ö. F., Selvi, O., Geredeli, Ç., Özden, F., Bilici, A. ... Aydın, A. (2024). The prognostic role of mismatch repair status and CDX-2 expression with inflammatory markers and pathological risk factors in stage ıı and ııı colon cancer: Multicenter real-life data. Journal of Gastrointestinal Cancer, 55(1), 227-236. http://dx.doi.org/10.1007/s12029-023-00953-0en_US
dc.identifier.issn1941-6628
dc.identifier.issn1941-6636
dc.identifier.urihttp://dx.doi.org/10.1007/s12029-023-00953-0
dc.identifier.urihttps://hdl.handle.net/20.500.12511/12563
dc.description.abstractObjective: Colorectal cancer is common worldwide, and adjuvant treatment’s benefit is still controversial. We designed this study to determine the role of MSI and CDX-2 status determined by immunohistochemistry (IHC) combined with the inflammatory markers and pathological parameters in predicting disease recurrence in stage II and III colon cancer. Methods: A total of 226 stage II/III colon cancer patients with a median age of 59 years who underwent initial surgery were included in this retrospective study. The pathologic assessment of MSI and CDX-2 was performed twice by immunohistochemistry (IHC) and two different pathologists. No staining/weak staining below 10% of the tumor was accepted as CDX-2 negative, and any MSI clones with weak staining below 10% were accepted as MSI-H. The laboratory parameters were noted at the initial diagnosis. Results: One hundred twenty-one and 105 patients were diagnosed with stage III and II colon cancer. 58.0% of patients were male, 46 (20.4%) of tumor tissue were MSS, and 17 (7.5%) were CDX-2 negative. One hundred twenty-nine tumors were localized in the right colon. Disease recurrence was significantly correlated with tumor localization, CDX-2 status, stage at diagnosis, and preoperatively median CRP and CEA levels. DFS rates for MSS patients with CDX-2 negative and positive were 36.7% and 98.1%, respectively [p < 0.001]. There was no significant correlation between MSI status and CDX-2 status. MSI status, the presence of adjuvant treatment, and systemic inflammatory markers were not significant prognostic factors for DFS. CDX-2 status [HR:0.08, CI 95% 0.03–0.17, p < 0.001 HR: 1.7, CI 95% 1.1–3.0, p = 0.03], disease stage [HR:2.6, CI 95% 1.43–4.74], and preoperatively CEA levels [HR:4.1 CI 95% 2.18–785, p < 0.001 were independent significant prognostic factors for DFS. Conclusion: CDX-2 loss was an independent prognostic factor for DFS and disease recurrence in early-stage colon cancer. MSS patients with CDX-2 loss had significantly worse survival outcomes, and this might be the reason for deciding on adjuvant chemotherapy.en_US
dc.language.isoengen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCDX-2en_US
dc.subjectColon Canceren_US
dc.subjectDisease-Free Survivalen_US
dc.subjectInflammatory Markeren_US
dc.subjectMSIen_US
dc.titleThe prognostic role of mismatch repair status and CDX-2 expression with inflammatory markers and pathological risk factors in stage ıı and ııı colon cancer: Multicenter real-life dataen_US
dc.typearticleen_US
dc.relation.ispartofJournal of Gastrointestinal Canceren_US
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Tıbbi Patoloji Ana Bilim Dalıen_US
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, İç Hastalıkları Ana Bilim Dalıen_US
dc.authorid0000-0002-0077-6971en_US
dc.authorid0000-0002-2901-4671en_US
dc.authorid0000-0003-2715-4002en_US
dc.authorid0000-0001-8802-6376en_US
dc.authorid0000-0002-5823-1704en_US
dc.authorid0000-0002-8610-768Xen_US
dc.identifier.volume55en_US
dc.identifier.issue1en_US
dc.identifier.startpage227en_US
dc.identifier.endpage236en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.doi10.1007/s12029-023-00953-0en_US
dc.institutionauthorGöktaş Aydın, Sabin
dc.institutionauthorÖlmez, Ömer Fatih
dc.institutionauthorÖzden, Ferhat
dc.institutionauthorBilici, Ahmet
dc.institutionauthorAçıkgöz, Özgür
dc.institutionauthorKarcı, Ebru
dc.institutionauthorKutlu, Yasin
dc.institutionauthorHamdard, Jamshid
dc.institutionauthorAydın, Ahmet
dc.identifier.wos001014471300001en_US
dc.identifier.scopus2-s2.0-85162997296en_US
dc.identifier.pmid37347353en_US
dc.identifier.scopusqualityQ3en_US


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