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dc.contributor.authorKarimkhani, Hadi
dc.contributor.authorShojaolsadati, Paria
dc.contributor.authorYiğitbaşı, Türkan
dc.contributor.authorKolbaşı, Bircan
dc.contributor.authorEmekli, Neslin
dc.date.accessioned2024-05-17T10:44:05Z
dc.date.available2024-05-17T10:44:05Z
dc.date.issued2024en_US
dc.identifier.citationKarimkhani, H., Shojaolsadati, P., Yiğitbaşı, T., Kolbaşı, B. ve Emekli, N. (2024). The effect of calpain inhibitor-I on copper oxide nanoparticle-induced damage and cerebral ischemia-reperfusion in a rat model. Biomedicine and Pharmacotherapy, 174. http://dx.doi.org/10.1016/j.biopha.2024.116539en_US
dc.identifier.issn0753-3322
dc.identifier.urihttp://dx.doi.org/10.1016/j.biopha.2024.116539
dc.identifier.urihttps://hdl.handle.net/20.500.12511/12478
dc.description.abstractThis study aimed to investigate the effects of the calpain inhibitor N-Acetyl-Leu-Leu-norleucinal (ALLN) on neuroapoptotic cell damage caused by Copper Oxide Nanoparticles (CuO-NP) and exacerbation of damage through brain ischemia/reperfusion (I/R) in a rat model. Male Wistar Albino rats (n=80) were divided into eight groups: Control, I/R, CuO-NP, CuO-NP+I/R, I/R+ALLN, CuO-NP+ALLN, CuO-NP+I/R+ALLN, and DMSO. Biochemical markers (MBP, S100B, NEFL, NSE, BCL-2, Cyt-C, Calpain, TNF-α, Caspase-3, MDA, and CAT) were measured in serum and brain tissue samples. Histological examinations (H&E staining), DNA fragmentation analysis (TUNEL) were performed, along with Caspase-3 assessment. The ALLN-treated groups exhibited significant improvements in biochemical markers and a remarkable reduction in apoptosis compared to the damaged groups (CuO-NP and I/R). H&E and Caspase-3 staining revealed damage-related morphological changes and reduced apoptosis in the ALLN-treated group. However, no differences were observed among the groups with TUNEL staining. The findings suggest that ALLN, as a calpain inhibitor, has potential implications for anti-apoptotic treatment, specifically in mitigating neuroapoptotic cell damage caused by CuO-NP and I/R.en_US
dc.language.isoengen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.rightsAttribution 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectAnti-Apoptotic Treatmenten_US
dc.subjectBrain İschemia-Reperfusion (I/R)en_US
dc.subjectCalpain Inhibitoren_US
dc.subjectCerebral İschemia-Reperfusion (I/R)en_US
dc.subjectCopper Oxide Nanoparticle (Cuo-NP)en_US
dc.subjectRat Modelen_US
dc.titleThe effect of calpain inhibitor-I on copper oxide nanoparticle-induced damage and cerebral ischemia-reperfusion in a rat modelen_US
dc.typearticleen_US
dc.relation.ispartofBiomedicine and Pharmacotherapyen_US
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Histoloji ve Embriyoloji Ana Bilim Dalıen_US
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Biyokimya Ana Bilim Dalıen_US
dc.authorid0000-0002-0675-1839en_US
dc.authorid0000-0001-7933-4262en_US
dc.authorid0000-0002-0109-5086en_US
dc.identifier.volume174en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.doi10.1016/j.biopha.2024.116539en_US
dc.institutionauthorYiğitbaşı, Türkan
dc.institutionauthorKolbaşı, Bircan
dc.institutionauthorEmekli, Neslin
dc.identifier.scopus2-s2.0-85190292716en_US
dc.identifier.pmid38615610en_US
dc.identifier.scopusqualityQ1en_US


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