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dc.contributor.authorYurttaş, Leyla
dc.contributor.authorDemirayak, Şeref
dc.contributor.authorÇiftçi, Gülşen Akalın
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T19:36:45Z
dc.date.available10.07.201910:49:14
dc.date.available2019-07-10T19:36:45Z
dc.date.issued2015
dc.identifier.citationYurttaş L., Demirayak Ş. ve Çiftçi, G. A. (2015). Cytotoxic, antiproliferative and apoptotic effects of new benzimidazole derivatives on A549 lung carcinoma and C6 glioma cell lines. Anti-Cancer Agents in Medicinal Chemistry, 15(9), 1174-1184. https://dx.doi.org/10.2174/1871520615666150703122625en_US
dc.identifier.issn1871-5206
dc.identifier.urihttps://hdl.handle.net/20.500.12511/1246
dc.identifier.urihttps://dx.doi.org/10.2174/1871520615666150703122625
dc.description.abstractBenzimidazole ring is a versatile structure which has been extensively utilized in medicinal chemistry. Since we are working on 1,2-disubstutited benzimidazoles, we have reported new antitumor active derivatives. As a continuation to our previous work, we have synthesized a new series of 1-(2-aryl-2-oxoethyl)-2-[(N,N- dimethylamino/pyrrolidinyl/piperidinyl)thiocarbamoyl] benzimidazole derivatives. Anticancer activity of the compounds was evaluated using MTT assay, BrdU assay and flow cytometric analysis on A549 human lung carcinoma and C6 rat glioma cell lines. Compounds bearing dimethylamino moiety exhibited higher antitumor activity.en_US
dc.language.isoengen_US
dc.publisherBentham Science Publishersen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAntiproliferativeen_US
dc.subjectApoptosisen_US
dc.subjectBenzimidazoleen_US
dc.subjectCytotoxicityen_US
dc.titleCytotoxic, antiproliferative and apoptotic effects of new benzimidazole derivatives on A549 lung carcinoma and C6 glioma cell linesen_US
dc.typearticleen_US
dc.relation.journalAnti-Cancer Agents in Medicinal Chemistryen_US
dc.departmentİstanbul Medipol Üniversitesi, Eczacılık Fakültesi, Eczacılık Meslek Bilimleri Bölümü, Farmasötik Kimya Ana Bilim Dalıen_US
dc.identifier.volume15en_US
dc.identifier.issue9en_US
dc.identifier.startpage1174en_US
dc.identifier.endpage1184en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.doi10.2174/1871520615666150703122625en_US


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