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dc.contributor.authorBaşaran, Recep
dc.contributor.authorÖnöz, Mustafa
dc.contributor.authorBölükbaşı, Fatih Han
dc.contributor.authorEfendioğlu, Mustafa
dc.contributor.authorSav, Aydın
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T19:36:44Z
dc.date.available10.07.201910:49:14
dc.date.available2019-07-10T19:36:44Z
dc.date.issued2017en_US
dc.identifier.citationBaşaran, R., Önöz, M., Bölükbaşı, F. H., Efendioğlu, M. ve Sav, A. (2017). Low O6-methylguanine-dna methytransferase (MGMT) and pan-cytokeratin (PAN-CK) expression via immunohistochemistry in pituitary adenomas. Acta Endocrinologica, 13(3), 282-293. https://dx.doi.org/10.4183/aeb.2017.282en_US
dc.identifier.issn1841-0987
dc.identifier.issn1843-066X
dc.identifier.urihttps://hdl.handle.net/20.500.12511/1242
dc.identifier.urihttps://dx.doi.org/10.4183/aeb.2017.282
dc.description.abstractIntroduction. Pituitary adenomas (PA) are the third most common intracranial tumors, with an incidence rate of 10-15%. More than half are invasive, infiltrating adjacent structures. The primary objective of this project was to determine whether MGMT expression is associated with the invasiveness of PA. Material and Method. All patients who underwent surgical decompression consecutively between 2007- 2012 were included. All data were obtained from the case records. Formalin-fixed paraffin-embedded (FFPE) tissue specimens were stained with hematoxylin and eosin (HE) and then examined via light microscope. Paraffin blocks that lacked necrosis and hemorrhage were chosen for histologic examination. In addition to an immunoprofile battery that consisted of Ki-67 and p53, MGMT, S-100 and Pan-CK were evaluated as well. Results. The subjects included 25 women and 15 men. The mean age was 48.9 ± 14.5 years. Of these, 63% of cases involved the invasion of adjacent structures. Of the PA, 17 (42%) were non-functioning pituitary adenomas (NFPA). There was a statistically significant relationship between the invasiveness and Ki-67, p53, MGMT expression, and prolactinoma. Gonodotropinomas were mostly non-invasive. FPAs presented invasive features more frequently than NFPAs. Pan-CK was positive in GH-secreting adenomas but negative in FSH- and LH-secreting adenomas. Conclusion. Ki-67 and p53 in lower expression level can be used for evaluating invasiveness but not for recurrence. MGMT expression can be a useful IHC indicator for invasiveness. However, Pan-CK cannot be used for invasiveness or aggressiveness.en_US
dc.language.isoengen_US
dc.publisherActa Endocrinologica Foundationen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCytokeratinen_US
dc.subjectImmunohistochemistryen_US
dc.subjectInvasivenessen_US
dc.subjectKi-67en_US
dc.subjectMGMTen_US
dc.subjectP53en_US
dc.subjectPituitary Adenomaen_US
dc.titleLow O6-methylguanine-dna methytransferase (MGMT) and pan-cytokeratin (PAN-CK) expression via immunohistochemistry in pituitary adenomasen_US
dc.typearticleen_US
dc.relation.journalActa Endocrinologicaen_US
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Beyin ve Sinir Cerrahisi Ana Bilim Dalıen_US
dc.identifier.volume13en_US
dc.identifier.issue3en_US
dc.identifier.startpage282en_US
dc.identifier.endpage293en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.doi10.4183/aeb.2017.282en_US


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