Evaluation of treatment outcomes and tolerability in older patients with rectal cancer treated with radiotherapy accompanied by the G-8 geriatric score: TROD13–003 multicenter study
Göster/ Aç
Erişim
info:eu-repo/semantics/openAccessTarih
2024Yazar
Güzelöz, ZelihaGörken, İlknur Bilkay
Aydın, Barbaros
Sert, Fatma
Yalman, Deniz
Parvizi, Murtaza
Avcı, Gülhan Güler
Altınok, Pelin
Halis, Hatice
Ergen, Şefika Arzu
Akgün, Züleyha
Özkan, Elif
Güney, Yıldız
Karaçetin, Didem
Kaydıhan, Nuri
Düzova, Mürsel
Akın, Murat
Uysal, Bora
Erdoğan, Mihriban
Ellidokuz, Hülya
Aksu, Gamze
Metcalfe, Evrim
Üst veri
Tüm öğe kaydını gösterKünye
Güzelöz, Z., Görken, İ. B., Aydın, B. Sert, F., Yalman, D., Parvizi, M. ... Metcalfe, E. (2024). Evaluation of treatment outcomes and tolerability in older patients with rectal cancer treated with radiotherapy accompanied by the G-8 geriatric score: TROD13–003 multicenter study. Journal of Geriatric Oncology, (15)3. http://dx.doi.org/10.1016/j.jgo.2024.101739Özet
Introduction: The choice of treatment for rectal cancer often differs in older and younger patients, with the rate of radiotherapy use lower among older adults. In our
daily practice, when evaluating a frail older patient with rectal cancer, we usually choose to give less treatment. This may be due to concern that the patient will not
be able to tolerate radiotherapy. The Geriatric 8 score (G8GS) is a guide to evaluating treatment tolerability as it relates to frailty in older adults with cancer. The aim
of this study was to evaluate treatment outcomes and tolerability in older patients with rectal cancer treated with radiotherapy (RT) accompanied by G8GS.
Materials and Methods: Patients aged 65 and older with stage I-III rectal adenocarcinoma who were treated with RT and had a G8 evaluation were included in this
multicenter retrospective study. Prognostic factors related to G8GS were calculated using Chi-square and logistic regression tests and survival rates were calculated
by the Kaplan–Meier test using the SPSS v24.0 software. All p-values ≤0.05 were considered statistically significant.
Results: A total of 699 patients from 16 national institutions were evaluated. The median age was 72 years (range 65–96), and the median follow-up was 43 (range 1-
190) months. Four hundred and fifty patients (64%) were categorized as frail with G8GS ≤14 points. Frail patients had higher ages (p = 0.001) and more
comorbidities (p = 0.001). Ability to receive concomitant and/or adjuvant chemotherapy rates were significantly higher in fit patients (p = 0.002 and p = 0.001,
respectively). No significant difference was observed in terms of grade 3-4 early and late toxicity for both groups. Cancer-related death was higher (p = 0.003), and 5-
and 8-year survival rates were significantly lower (p = 0.001), in the frail group. Age and being frail were significantly associated with survival.
Scopus Q Kategorisi
Q2Kaynak
Journal of Geriatric OncologyCilt
15Sayı
3Koleksiyonlar
- Makale Koleksiyonu [3655]
- PubMed İndeksli Yayınlar Koleksiyonu [4054]
- Scopus İndeksli Yayınlar Koleksiyonu [6295]
İlgili Öğeler
Başlık, yazar, küratör ve konuya göre gösterilen ilgili öğeler.
-
Prognostic factors for regorafenib treatment in patients with refractory metastatic colorectal cancer: A real-life retrospective multi-center study
Göktaş Aydın, Sabin; Kavak, Engin Eren; Topçu, Atakan; Bayramgil, Ayberk; Akgül, Fahri; Kahraman, Seda; Aykan, Musa Barış; Altıntaş, Yunus Emre; Helvacı, Kaan; Ürün, Yüksel; Bilici, Ahmet; Şeker, Mesut (Association of Basic Medical Sciences of FBIH, 2023)Regorafenib, an oral multikinase inhibitor, has improved survival in metastatic colorectal cancer (mCRC) patients who have progressed on standard therapies. Our study aimed to evaluate prognostic factors influencing ... -
Assessment of prognostic factors and adjuvant treatment modalities in adult head and neck soft tissue sarcoma patients treated with upfront surgery
Akagündüz, Baran; Akın Telli, Tuğba; Göksu, Sema Sezgin; Yıldırım, Hasan Çağrı; Özer, Muhammet; Göktaş Aydın, Sabin; Özyurt, Neslihan; Karacin, Cengiz; Paydaş, Semra; Doğan, Mutlu (Cureus Inc., 2021)ObjectivesHead and neck soft tissue sarcomas (HNSTSs) are a heterogeneous group of rare tumors. Surgical resection with negative margins remains the standard primary treatment for patients with HNSTS. The role of chemotherapy ... -
Neoadjuvan kemoterapi alan lokal ileri meme kanserli hastalarda moleküler alt tiplere göre yanıt oranları ile klinik sonuçlar üzerine etkili prediktif ve prognostik faktörlerin gözden geçirilmesi
Yıldız, Anıl (İstanbul Medipol Üniversitesi Tıp Fakültesi, 2019)Meme kanseri dünya genelinde kadınlarda en sık görülen kanser türüdür. Günümüzde çalışmalarda neoadjuvan tedavi almış meme kanserli hastalarda tedaviye yanıtın moleküler alt tiplere göre farklılık gösterdiği, bunun tedavi ...