dc.contributor.author | Baard, Joyce | |
dc.contributor.author | Cormio, Luigi | |
dc.contributor.author | Dasgupta, Ranan | |
dc.contributor.author | Maruzzi, Daniele | |
dc.contributor.author | Rais-Bahrami, Soroush | |
dc.contributor.author | Serrano, Alvaro | |
dc.contributor.author | Geavlete, Bogdan | |
dc.contributor.author | Giannakopoulos, Stilianos | |
dc.contributor.author | de la Rosette, Jean J. M. C. H. | |
dc.contributor.author | del Pilar Laguna Pes, Maria | |
dc.date.accessioned | 2024-04-03T09:22:28Z | |
dc.date.available | 2024-04-03T09:22:28Z | |
dc.date.issued | 2024 | en_US |
dc.identifier.citation | Baard, J., Cormio, L., Dasgupta, R., Maruzzi, D., Rais-Bahrami, S., Serrano, A. ... del Pilar Laguna Pes, M. (2024). Unveiling the challenges of UTUC biopsies and cytology: insights from a global real-world practice study. World Journal of Urology, 42(1). https://dx.doi.org/10.1007/s00345-024-04866-w | en_US |
dc.identifier.issn | 0724-4983 | |
dc.identifier.uri | https://dx.doi.org/10.1007/s00345-024-04866-w | |
dc.identifier.uri | https://hdl.handle.net/20.500.12511/12413 | |
dc.description.abstract | Purpose: Diagnostic ureteroscopy (dURS) is optional in the assessment of patients with upper tract urothelial carcinoma (UTUC) and provides the possibility of obtaining histology. Methods: To evaluate endoscopic biopsy techniques and outcomes, we assessed data from patients from the CROES-UTUC registry. The registry includes multicenter prospective collected data on diagnosis and management of patients suspected having UTUC. Results: We assessed 2380 patients from 101 centers. dURS with biopsy was performed in 31.6% of patients. The quality of samples was sufficient for diagnosis in 83.5% of cases. There was no significant association between biopsy techniques and quality (p = 0.458). High-grade biopsy accurately predicted high-grade disease in 95.7% and high-risk stage disease in 86%. In ureteroscopic low-grade tumours, the prediction of subsequent low-grade disease was 66.9% and low-risk stage Ta-disease 35.8%. Ureteroscopic staging correctly predicted non-invasive Ta-disease and ≥ T1 disease in 48.9% and 47.9% of patients, respectively. Cytology outcomes did not provide additional value in predicting tumour grade. Conclusion: Biopsy results adequately predict high-grade and high-risk disease, but approximately one-third of patients are under-staged. Two-thirds of patients with low-grade URS-biopsy have high-risk stage disease, highlighting the need for improved diagnostics to better assess patient risk and guide treatment decisions. Clinical trial registration: The study was registered at ClinicalTrials.gov (ClinicalTrials.gov NCT02281188; https://clinicaltrials.gov/ct2/show/NCT02281188). | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Springer Science and Business Media Deutschland GmbH | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | Biopsy | en_US |
dc.subject | Cytology | en_US |
dc.subject | KSS | en_US |
dc.subject | Upper tract urothelial cancer | en_US |
dc.subject | Ureteroscopy | en_US |
dc.title | Unveiling the challenges of UTUC biopsies and cytology: insights from a global real-world practice study | en_US |
dc.type | article | en_US |
dc.relation.ispartof | World Journal of Urology | en_US |
dc.department | İstanbul Medipol Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Üroloji Ana Bilim Dalı | en_US |
dc.department | İstanbul Medipol Üniversitesi, Uluslararası Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Üroloji Ana Bilim Dalı | en_US |
dc.authorid | 0000-0002-6308-1763 | en_US |
dc.authorid | 0000-0003-0906-4417 | en_US |
dc.identifier.volume | 42 | en_US |
dc.identifier.issue | 1 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.identifier.doi | 10.1007/s00345-024-04866-w | en_US |
dc.institutionauthor | de la Rosette, Jean J. M. C. H. | |
dc.institutionauthor | del Pilar Laguna Pes, Maria | |
dc.identifier.scopus | 2-s2.0-85188256598 | en_US |
dc.identifier.pmid | 38507109 | en_US |
dc.identifier.scopusquality | Q1 | en_US |