Basit öğe kaydını göster

dc.contributor.authorÇakıcı, Çağrı
dc.contributor.authorDaylan, Benay
dc.contributor.authorÜnlüer, Rüveyde Safiye
dc.contributor.authorEmekli Alturfan, Ebru
dc.contributor.authorAyla, Şule
dc.contributor.authorEren Gözel, Hilal
dc.contributor.authorYiğit, Pakize
dc.contributor.authorYavuz Dokgöz, Elif
dc.contributor.authorYiğitbaşı, Türkan
dc.date.accessioned2024-03-08T07:57:40Z
dc.date.available2024-03-08T07:57:40Z
dc.date.issued2024en_US
dc.identifier.citationÇakıcı, Ç., Daylan, B., Ünlüer, R. S., Emekli Alturfan, E., Ayla, Ş., Eren Gözel, H. ... Yiğitbaşı, T. (2024). LDH-A inhibitor as a remedy to potentiate the anticancer effect of docetaxel in prostate cancer. Journal of Cancer, 15(3), 590-602. https://dx.doi.org/10.7150/jca.86283en_US
dc.identifier.issn1837-9664
dc.identifier.urihttps://dx.doi.org/10.7150/jca.86283
dc.identifier.urihttps://hdl.handle.net/20.500.12511/12348
dc.description.abstractIncreased LDH-A activity promotes tumor growth, migration, invasion, and metastasis. This study aimed to investigate the effects of the combination of LDH-A inhibitor and Docetaxel on apoptosis and epithelial-mesenchymal transition (EMT) in the murine prostate cancer (PCa) model. The prostate cancer murine model was developed subcutaneously in 50 male B57CL/6 mice using the Tramp-C2 prostate cancer cell line. From the tumor tissue samples, apoptosis analysis was performed using TUNEL staining, and EMT was investigated using western blot and qPCR. Hematoxylin-eosin staining (HE) and Periodic acid-Schiff staining were used to histopathologically examine liver and kidney tissues. Lactate levels revealed that the Warburg effect was reversed with the LDH-A inhibitor. Both serum and tumor tissue apoptosis increased, and tumor sizes reduced in PCa+LDH-A inhibitor + Docetaxel treatment groups (p<0.05). The combination of LDH-A inhibitor and Docetaxel inhibited EMT mechanism by causing a decrease in Snail, Slug, Twist, and HIF-1α expressions as well as a decrease in N-cadherin and an increase in E-cadherin levels. Reprogramming glucose metabolism with an LDH-A inhibitor can increase the effectiveness of Docetaxel on apoptosis and metastasis mechanisms in PCa.en_US
dc.description.sponsorshipIstanbul Medipol University Scientific Research Projects Uniten_US
dc.language.isoengen_US
dc.publisherIvyspring International Publisheren_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.rightsAttribution 4.0 International*
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/*
dc.subjectApoptosisen_US
dc.subjectEMTen_US
dc.subjectLDH-A Inhibitoren_US
dc.subjectProstate Canceren_US
dc.subjectWarburg Effecten_US
dc.titleLDH-A inhibitor as a remedy to potentiate the anticancer effect of docetaxel in prostate canceren_US
dc.typearticleen_US
dc.relation.ispartofJournal of Canceren_US
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Biyokimya Ana Bilim Dalıen_US
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Histoloji ve Embriyoloji Ana Bilim Dalıen_US
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Biyoistatistik ve Tıp Bilişimi Ana Bilim Dalıen_US
dc.authorid0000-0002-8662-5284en_US
dc.authorid0000-0002-8302-1127en_US
dc.authorid0000-0002-5919-1986en_US
dc.authorid0000-0002-0675-1839en_US
dc.identifier.volume15en_US
dc.identifier.issue3en_US
dc.identifier.startpage590en_US
dc.identifier.endpage602en_US
dc.relation.tubitakinfo:eu-repo/grantAgreement/TUBITAK/SOBAG/119S850
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.doi10.7150/jca.86283en_US
dc.institutionauthorÇakıcı, Çağrı
dc.institutionauthorDaylan, Benay
dc.institutionauthorÜnlüer, Rüveyde Safiye
dc.institutionauthorYiğit, Pakize
dc.institutionauthorYiğitbaşı, Türkan
dc.identifier.wosqualityQ2en_US
dc.identifier.wos001167297900004en_US
dc.identifier.scopus2-s2.0-85185716416en_US
dc.identifier.pmid38213726en_US
dc.identifier.scopusqualityQ2en_US


Bu öğenin dosyaları:

Thumbnail

Bu öğe aşağıdaki koleksiyon(lar)da görünmektedir.

Basit öğe kaydını göster

info:eu-repo/semantics/openAccess
Aksi belirtilmediği sürece bu öğenin lisansı: info:eu-repo/semantics/openAccess