dc.contributor.author | Erol, Vedat Buğra | |
dc.contributor.author | Göktaş Aydın, Sabin | |
dc.contributor.author | Bilici, Ahmet | |
dc.contributor.author | Çakır, Aslı | |
dc.contributor.author | Açıkgöz, Özgür | |
dc.contributor.author | Ölmez, Ömer Fatih | |
dc.contributor.author | Basım, Pelin | |
dc.date.accessioned | 2024-02-22T07:52:01Z | |
dc.date.available | 2024-02-22T07:52:01Z | |
dc.date.issued | 2023 | en_US |
dc.identifier.citation | Erol, V. B., Göktaş Aydın, S., Bilici, A., Çakır, A., Açıkgöz, Ö., Ölmez, Ö. F. ... Basım, P. (2023). Relationship between the change in tumour-infiltrating lymphocyte level and residual tumour after neoadjuvant chemotherapy in patients with locally advanced breast cancer. Journal of Chemotherapy, 35(7), 662-670. https://dx.doi.org/10.1080/1120009X.2023.2247207 | en_US |
dc.identifier.issn | 1120-009X | |
dc.identifier.issn | 1973-9478 | |
dc.identifier.uri | https://dx.doi.org/10.1080/1120009X.2023.2247207 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12511/12301 | |
dc.description.abstract | To evaluate the tumour-infiltrating lymphocyte (TIL) rates in breast tissue before and after neoadjuvant chemotherapy (NAC) and their impact on survival, eighty-four patients with locally advanced breast cancer (LABC) were assessed. Pre- and post-NAC TIL levels were determined using biopsy and surgical specimens, respectively. The median TIL rate was significantly different before (17.5%) and after (5%) NAC. Pre- and postoperative Ki-67 index, molecular subtype, pre- and post-NAC TIL concentration, and preoperative residual-cancer-burden TIL were significantly associated with pathological complete response (pCR). Specifically, higher pre-NAC TIL levels were associated with higher pCR rates. Postoperative Ki-67 index and pCR, and postoperative Ki-67 index were significant predictors of disease-free (DFS) and overall survival, respectively. The independent prognostic factors for DFS were postoperative Ki-67 score (hazard ratio [HR]: 6.16; p = 0.012), post-NAC TIL score (HR: 0.42; P = 0.041), and pCR (HR: 0.10; P = 0.038). Our study confirms that higher pre-NAC and lower postoperative TIL levels may be surrogate factors for longer DFS, and postoperative TIL rate may predict post-NAC pCR in patients with LABC. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Taylor and Francis Ltd. | en_US |
dc.rights | info:eu-repo/semantics/embargoedAccess | en_US |
dc.subject | Breast Cancer | en_US |
dc.subject | Breast Surgery | en_US |
dc.subject | Disease-Free Survival | en_US |
dc.subject | Neoadjuvant Chemotherapy | en_US |
dc.subject | Pathological Response | en_US |
dc.subject | Tumour-Infiltrating Lymphocyte | en_US |
dc.title | Relationship between the change in tumour-infiltrating lymphocyte level and residual tumour after neoadjuvant chemotherapy in patients with locally advanced breast cancer | en_US |
dc.type | article | en_US |
dc.relation.ispartof | Journal of Chemotherapy | en_US |
dc.department | İstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, İç Hastalıkları Ana Bilim Dalı | en_US |
dc.department | İstanbul Medipol Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Tıbbi Patoloji Ana Bilim Dalı | en_US |
dc.department | İstanbul Medipol Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Genel Cerrahi Ana Bilim Dalı | en_US |
dc.authorid | 0000-0002-3793-5251 | en_US |
dc.authorid | 0000-0002-0077-6971 | en_US |
dc.authorid | 0000-0002-0443-6966 | en_US |
dc.authorid | 0000-0003-0128-6947 | en_US |
dc.authorid | 0000-0003-2715-4002 | en_US |
dc.authorid | 0000-0001-7934-7039 | en_US |
dc.authorid | 0000-0002-9452-9276 | en_US |
dc.identifier.volume | 35 | en_US |
dc.identifier.issue | 7 | en_US |
dc.identifier.startpage | 662 | en_US |
dc.identifier.endpage | 670 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.identifier.doi | 10.1080/1120009X.2023.2247207 | en_US |
dc.institutionauthor | Erol, Vedat Buğra | |
dc.institutionauthor | Göktaş Aydın, Sabin | |
dc.institutionauthor | Bilici, Ahmet | |
dc.institutionauthor | Çakır, Aslı | |
dc.institutionauthor | Açıkgöz, Özgür | |
dc.institutionauthor | Ölmez, Ömer Fatih | |
dc.institutionauthor | Basım, Pelin | |
dc.identifier.wosquality | Q4 | en_US |
dc.identifier.wos | 001051927300001 | en_US |
dc.identifier.scopus | 2-s2.0-85168464195 | en_US |
dc.identifier.pmid | 37599454 | en_US |
dc.identifier.scopusquality | Q3 | en_US |